Untargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma

Abstract Feline chronic enteropathy (CE) is a common gastrointestinal disorder in cats and mainly comprises inflammatory bowel disease (IBD) and small cell lymphoma (SCL). Differentiation between IBD and SCL can be diagnostically challenging. We characterized the fecal metabolome of 14 healthy cats...

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Autores principales:	Sina Marsilio, Betty Chow, Steve L. Hill, Mark R. Ackermann, J. Scot Estep, Benjamin Sarawichitr, Rachel Pilla, Jonathan A. Lidbury, Joerg M. Steiner, Jan S. Suchodolski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d5c6ed5e4e464c84becca9ef6a2029b4
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spelling	oai:doaj.org-article:d5c6ed5e4e464c84becca9ef6a2029b42021-12-02T14:53:43ZUntargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma10.1038/s41598-021-88707-52045-2322https://doaj.org/article/d5c6ed5e4e464c84becca9ef6a2029b42021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88707-5https://doaj.org/toc/2045-2322Abstract Feline chronic enteropathy (CE) is a common gastrointestinal disorder in cats and mainly comprises inflammatory bowel disease (IBD) and small cell lymphoma (SCL). Differentiation between IBD and SCL can be diagnostically challenging. We characterized the fecal metabolome of 14 healthy cats and 22 cats with naturally occurring CE (11 cats with IBD and 11 cats with SCL). Principal component analysis and heat map analysis showed distinct clustering between cats with CE and healthy controls. Random forest classification revealed good group prediction for healthy cats and cats with CE, with an overall out-of-bag error rate of 16.7%. Univariate analysis indicated that levels of 84 compounds in cats with CE differed from those in healthy cats. Polyunsaturated fatty acids held discriminatory power in differentiating IBD from SCL. Metabolomic profiles of cats with CE resembled those in people with CE with significant alterations of metabolites related to tryptophan, arachidonic acid, and glutathione pathways.Sina MarsilioBetty ChowSteve L. HillMark R. AckermannJ. Scot EstepBenjamin SarawichitrRachel PillaJonathan A. LidburyJoerg M. SteinerJan S. SuchodolskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sina Marsilio Betty Chow Steve L. Hill Mark R. Ackermann J. Scot Estep Benjamin Sarawichitr Rachel Pilla Jonathan A. Lidbury Joerg M. Steiner Jan S. Suchodolski Untargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma
description	Abstract Feline chronic enteropathy (CE) is a common gastrointestinal disorder in cats and mainly comprises inflammatory bowel disease (IBD) and small cell lymphoma (SCL). Differentiation between IBD and SCL can be diagnostically challenging. We characterized the fecal metabolome of 14 healthy cats and 22 cats with naturally occurring CE (11 cats with IBD and 11 cats with SCL). Principal component analysis and heat map analysis showed distinct clustering between cats with CE and healthy controls. Random forest classification revealed good group prediction for healthy cats and cats with CE, with an overall out-of-bag error rate of 16.7%. Univariate analysis indicated that levels of 84 compounds in cats with CE differed from those in healthy cats. Polyunsaturated fatty acids held discriminatory power in differentiating IBD from SCL. Metabolomic profiles of cats with CE resembled those in people with CE with significant alterations of metabolites related to tryptophan, arachidonic acid, and glutathione pathways.
format	article
author	Sina Marsilio Betty Chow Steve L. Hill Mark R. Ackermann J. Scot Estep Benjamin Sarawichitr Rachel Pilla Jonathan A. Lidbury Joerg M. Steiner Jan S. Suchodolski
author_facet	Sina Marsilio Betty Chow Steve L. Hill Mark R. Ackermann J. Scot Estep Benjamin Sarawichitr Rachel Pilla Jonathan A. Lidbury Joerg M. Steiner Jan S. Suchodolski
author_sort	Sina Marsilio
title	Untargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma
title_short	Untargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma
title_full	Untargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma
title_fullStr	Untargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma
title_full_unstemmed	Untargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma
title_sort	untargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d5c6ed5e4e464c84becca9ef6a2029b4
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Untargeted metabolomic analysis in cats with naturally occurring inflammatory bowel disease and alimentary small cell lymphoma

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