Comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma

Abstract Ameloblastomas are odontogenic tumors that are rare in people but have a relatively high prevalence in dogs. Because canine acanthomatous ameloblastomas (CAA) have clinicopathologic and molecular features in common with human ameloblastomas (AM), spontaneous CAA can serve as a useful transl...

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Autores principales:	Santiago Peralta, Gerald E. Duhamel, William P. Katt, Kristiina Heikinheimo, Andrew D. Miller, Faraz Ahmed, Angela L. McCleary-Wheeler, Jennifer K. Grenier
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d5c7128c160c48f0a26af1a3052b03de
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spelling	oai:doaj.org-article:d5c7128c160c48f0a26af1a3052b03de2021-12-02T19:13:48ZComparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma10.1038/s41598-021-97430-02045-2322https://doaj.org/article/d5c7128c160c48f0a26af1a3052b03de2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97430-0https://doaj.org/toc/2045-2322Abstract Ameloblastomas are odontogenic tumors that are rare in people but have a relatively high prevalence in dogs. Because canine acanthomatous ameloblastomas (CAA) have clinicopathologic and molecular features in common with human ameloblastomas (AM), spontaneous CAA can serve as a useful translational model of disease. However, the molecular basis of CAA and how it compares to AM are incompletely understood. In this study, we compared the global genomic expression profile of CAA with AM and evaluated its dental origin by using a bulk RNA-seq approach. For these studies, healthy gingiva and canine oral squamous cell carcinoma served as controls. We found that aberrant RAS signaling, and activation of the epithelial-to-mesenchymal transition cellular program are involved in the pathogenesis of CAA, and that CAA is enriched with genes known to be upregulated in AM including those expressed during the early stages of tooth development, suggesting a high level of molecular homology. These results support the model that domestic dogs with spontaneous CAA have potential for pre-clinical assessment of targeted therapeutic modalities against AM.Santiago PeraltaGerald E. DuhamelWilliam P. KattKristiina HeikinheimoAndrew D. MillerFaraz AhmedAngela L. McCleary-WheelerJennifer K. GrenierNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Santiago Peralta Gerald E. Duhamel William P. Katt Kristiina Heikinheimo Andrew D. Miller Faraz Ahmed Angela L. McCleary-Wheeler Jennifer K. Grenier Comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma
description	Abstract Ameloblastomas are odontogenic tumors that are rare in people but have a relatively high prevalence in dogs. Because canine acanthomatous ameloblastomas (CAA) have clinicopathologic and molecular features in common with human ameloblastomas (AM), spontaneous CAA can serve as a useful translational model of disease. However, the molecular basis of CAA and how it compares to AM are incompletely understood. In this study, we compared the global genomic expression profile of CAA with AM and evaluated its dental origin by using a bulk RNA-seq approach. For these studies, healthy gingiva and canine oral squamous cell carcinoma served as controls. We found that aberrant RAS signaling, and activation of the epithelial-to-mesenchymal transition cellular program are involved in the pathogenesis of CAA, and that CAA is enriched with genes known to be upregulated in AM including those expressed during the early stages of tooth development, suggesting a high level of molecular homology. These results support the model that domestic dogs with spontaneous CAA have potential for pre-clinical assessment of targeted therapeutic modalities against AM.
format	article
author	Santiago Peralta Gerald E. Duhamel William P. Katt Kristiina Heikinheimo Andrew D. Miller Faraz Ahmed Angela L. McCleary-Wheeler Jennifer K. Grenier
author_facet	Santiago Peralta Gerald E. Duhamel William P. Katt Kristiina Heikinheimo Andrew D. Miller Faraz Ahmed Angela L. McCleary-Wheeler Jennifer K. Grenier
author_sort	Santiago Peralta
title	Comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma
title_short	Comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma
title_full	Comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma
title_fullStr	Comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma
title_full_unstemmed	Comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma
title_sort	comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d5c7128c160c48f0a26af1a3052b03de
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Comparative transcriptional profiling of canine acanthomatous ameloblastoma and homology with human ameloblastoma

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