Characterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya

Abstract Characterising the genomic variation and population dynamics of Plasmodium falciparum parasites in high transmission regions of Sub-Saharan Africa is crucial to the long-term efficacy of regional malaria elimination campaigns and eradication. Whole-genome sequencing (WGS) technologies can c...

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Autores principales:	Ashley Osborne, Emilia Manko, Mika Takeda, Akira Kaneko, Wataru Kagaya, Chim Chan, Mtakai Ngara, James Kongere, Kiyoshi Kita, Susana Campino, Osamu Kaneko, Jesse Gitaka, Taane G. Clark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d5c85ce9fdaf49dba64b728e4709019d
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spelling	oai:doaj.org-article:d5c85ce9fdaf49dba64b728e4709019d2021-12-02T18:37:12ZCharacterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya10.1038/s41598-021-99192-12045-2322https://doaj.org/article/d5c85ce9fdaf49dba64b728e4709019d2021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99192-1https://doaj.org/toc/2045-2322Abstract Characterising the genomic variation and population dynamics of Plasmodium falciparum parasites in high transmission regions of Sub-Saharan Africa is crucial to the long-term efficacy of regional malaria elimination campaigns and eradication. Whole-genome sequencing (WGS) technologies can contribute towards understanding the epidemiology and structural variation landscape of P. falciparum populations, including those within the Lake Victoria basin, a region of intense transmission. Here we provide a baseline assessment of the genomic diversity of P. falciparum isolates in the Lake region of Kenya, which has sparse genetic data. Lake region isolates are placed within the context of African-wide populations using Illumina WGS data and population genomic analyses. Our analysis revealed that P. falciparum isolates from Lake Victoria form a cluster within the East African parasite population. These isolates also appear to have distinct ancestral origins, containing genome-wide signatures from both Central and East African lineages. Known drug resistance biomarkers were observed at similar frequencies to those of East African parasite populations, including the S160N/T mutation in the pfap2mu gene, which has been associated with delayed clearance by artemisinin-based combination therapy. Overall, our work provides a first assessment of P. falciparum genetic diversity within the Lake Victoria basin, a region targeting malaria elimination.Ashley OsborneEmilia MankoMika TakedaAkira KanekoWataru KagayaChim ChanMtakai NgaraJames KongereKiyoshi KitaSusana CampinoOsamu KanekoJesse GitakaTaane G. ClarkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ashley Osborne Emilia Manko Mika Takeda Akira Kaneko Wataru Kagaya Chim Chan Mtakai Ngara James Kongere Kiyoshi Kita Susana Campino Osamu Kaneko Jesse Gitaka Taane G. Clark Characterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya
description	Abstract Characterising the genomic variation and population dynamics of Plasmodium falciparum parasites in high transmission regions of Sub-Saharan Africa is crucial to the long-term efficacy of regional malaria elimination campaigns and eradication. Whole-genome sequencing (WGS) technologies can contribute towards understanding the epidemiology and structural variation landscape of P. falciparum populations, including those within the Lake Victoria basin, a region of intense transmission. Here we provide a baseline assessment of the genomic diversity of P. falciparum isolates in the Lake region of Kenya, which has sparse genetic data. Lake region isolates are placed within the context of African-wide populations using Illumina WGS data and population genomic analyses. Our analysis revealed that P. falciparum isolates from Lake Victoria form a cluster within the East African parasite population. These isolates also appear to have distinct ancestral origins, containing genome-wide signatures from both Central and East African lineages. Known drug resistance biomarkers were observed at similar frequencies to those of East African parasite populations, including the S160N/T mutation in the pfap2mu gene, which has been associated with delayed clearance by artemisinin-based combination therapy. Overall, our work provides a first assessment of P. falciparum genetic diversity within the Lake Victoria basin, a region targeting malaria elimination.
format	article
author	Ashley Osborne Emilia Manko Mika Takeda Akira Kaneko Wataru Kagaya Chim Chan Mtakai Ngara James Kongere Kiyoshi Kita Susana Campino Osamu Kaneko Jesse Gitaka Taane G. Clark
author_facet	Ashley Osborne Emilia Manko Mika Takeda Akira Kaneko Wataru Kagaya Chim Chan Mtakai Ngara James Kongere Kiyoshi Kita Susana Campino Osamu Kaneko Jesse Gitaka Taane G. Clark
author_sort	Ashley Osborne
title	Characterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya
title_short	Characterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya
title_full	Characterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya
title_fullStr	Characterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya
title_full_unstemmed	Characterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya
title_sort	characterizing the genomic variation and population dynamics of plasmodium falciparum malaria parasites in and around lake victoria, kenya
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d5c85ce9fdaf49dba64b728e4709019d
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Characterizing the genomic variation and population dynamics of Plasmodium falciparum malaria parasites in and around Lake Victoria, Kenya

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