A long-term follow-up analysis of associations between tooth loss and multiple cancers in the Linxian General Population cohort

Poor oral health, indicated by tooth loss and periodontal disease, may be an important risk factor for various cancers. Prior studies have found inconsistent associations between tooth loss and several cancer types. Here, we examined the relationship between tooth loss and incident cases of multiple...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yukiko Yano, Jinhu Fan, Sanford M. Dawsey, Youlin Qiao, Christian C. Abnet
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Oral health Tooth loss Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/d5c8615c368040e0a7dc5931eeba019c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d5c8615c368040e0a7dc5931eeba019c
record_format	dspace
spelling	oai:doaj.org-article:d5c8615c368040e0a7dc5931eeba019c2021-12-01T05:06:31ZA long-term follow-up analysis of associations between tooth loss and multiple cancers in the Linxian General Population cohort2667-005410.1016/j.jncc.2021.01.002https://doaj.org/article/d5c8615c368040e0a7dc5931eeba019c2021-06-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2667005421000041https://doaj.org/toc/2667-0054Poor oral health, indicated by tooth loss and periodontal disease, may be an important risk factor for various cancers. Prior studies have found inconsistent associations between tooth loss and several cancer types. Here, we examined the relationship between tooth loss and incident cases of multiple cancers in the Linxian General Population Nutrition Intervention Trial cohort. In this large prospective cohort of over 29,000 participants, there were 3101, 1701, 626, 327, 348, and 179 incident esophageal, gastric cardia, gastric noncardia, liver, lung, and colorectal cancer cases, respectively, over 30 years of follow-up. Adjusted Cox proportional hazards regression models with time-varying covariates were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between tooth loss and cancer outcomes during three time intervals: ≤ 5 years (early), > 5 and ≤ 10 years (mid), > 10 years (late). Tooth loss was assessed as quartiles of the number of lost teeth in excess of the loess-smoothed, age-specific median number of teeth lost. For esophageal cancer, the increase in risk associated with the highest quartile of tooth loss was 25% (95% CI: 1.02, 1.52) in the mid time interval, but the association weakened thereafter. For gastric cardia cancer, the increase in risk associated with the highest quartile of tooth loss was 1.34 in both the early (95% CI: 1.06, 1.71) and mid time intervals (95% CI: 1.02, 1.76), with no significant associations in the late interval. Gastric noncardia cancer was only associated with the second quartile of tooth loss in the late time interval (HR = 1.54; 95% CI: 1.16, 2.04). All associations between tooth loss and liver, lung, and colorectal cancers were null. Tooth loss was associated with risk of esophageal and gastric cancers in this updated analysis from the cohort.Yukiko YanoJinhu FanSanford M. DawseyYoulin QiaoChristian C. AbnetElsevierarticleOral healthTooth lossCancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENJournal of the National Cancer Center, Vol 1, Iss 2, Pp 39-43 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Oral health Tooth loss Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Oral health Tooth loss Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yukiko Yano Jinhu Fan Sanford M. Dawsey Youlin Qiao Christian C. Abnet A long-term follow-up analysis of associations between tooth loss and multiple cancers in the Linxian General Population cohort
description	Poor oral health, indicated by tooth loss and periodontal disease, may be an important risk factor for various cancers. Prior studies have found inconsistent associations between tooth loss and several cancer types. Here, we examined the relationship between tooth loss and incident cases of multiple cancers in the Linxian General Population Nutrition Intervention Trial cohort. In this large prospective cohort of over 29,000 participants, there were 3101, 1701, 626, 327, 348, and 179 incident esophageal, gastric cardia, gastric noncardia, liver, lung, and colorectal cancer cases, respectively, over 30 years of follow-up. Adjusted Cox proportional hazards regression models with time-varying covariates were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between tooth loss and cancer outcomes during three time intervals: ≤ 5 years (early), > 5 and ≤ 10 years (mid), > 10 years (late). Tooth loss was assessed as quartiles of the number of lost teeth in excess of the loess-smoothed, age-specific median number of teeth lost. For esophageal cancer, the increase in risk associated with the highest quartile of tooth loss was 25% (95% CI: 1.02, 1.52) in the mid time interval, but the association weakened thereafter. For gastric cardia cancer, the increase in risk associated with the highest quartile of tooth loss was 1.34 in both the early (95% CI: 1.06, 1.71) and mid time intervals (95% CI: 1.02, 1.76), with no significant associations in the late interval. Gastric noncardia cancer was only associated with the second quartile of tooth loss in the late time interval (HR = 1.54; 95% CI: 1.16, 2.04). All associations between tooth loss and liver, lung, and colorectal cancers were null. Tooth loss was associated with risk of esophageal and gastric cancers in this updated analysis from the cohort.
format	article
author	Yukiko Yano Jinhu Fan Sanford M. Dawsey Youlin Qiao Christian C. Abnet
author_facet	Yukiko Yano Jinhu Fan Sanford M. Dawsey Youlin Qiao Christian C. Abnet
author_sort	Yukiko Yano
title	A long-term follow-up analysis of associations between tooth loss and multiple cancers in the Linxian General Population cohort
title_short	A long-term follow-up analysis of associations between tooth loss and multiple cancers in the Linxian General Population cohort
title_full	A long-term follow-up analysis of associations between tooth loss and multiple cancers in the Linxian General Population cohort
title_fullStr	A long-term follow-up analysis of associations between tooth loss and multiple cancers in the Linxian General Population cohort
title_full_unstemmed	A long-term follow-up analysis of associations between tooth loss and multiple cancers in the Linxian General Population cohort
title_sort	long-term follow-up analysis of associations between tooth loss and multiple cancers in the linxian general population cohort
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d5c8615c368040e0a7dc5931eeba019c
work_keys_str_mv	AT yukikoyano alongtermfollowupanalysisofassociationsbetweentoothlossandmultiplecancersinthelinxiangeneralpopulationcohort AT jinhufan alongtermfollowupanalysisofassociationsbetweentoothlossandmultiplecancersinthelinxiangeneralpopulationcohort AT sanfordmdawsey alongtermfollowupanalysisofassociationsbetweentoothlossandmultiplecancersinthelinxiangeneralpopulationcohort AT youlinqiao alongtermfollowupanalysisofassociationsbetweentoothlossandmultiplecancersinthelinxiangeneralpopulationcohort AT christiancabnet alongtermfollowupanalysisofassociationsbetweentoothlossandmultiplecancersinthelinxiangeneralpopulationcohort AT yukikoyano longtermfollowupanalysisofassociationsbetweentoothlossandmultiplecancersinthelinxiangeneralpopulationcohort AT jinhufan longtermfollowupanalysisofassociationsbetweentoothlossandmultiplecancersinthelinxiangeneralpopulationcohort AT sanfordmdawsey longtermfollowupanalysisofassociationsbetweentoothlossandmultiplecancersinthelinxiangeneralpopulationcohort AT youlinqiao longtermfollowupanalysisofassociationsbetweentoothlossandmultiplecancersinthelinxiangeneralpopulationcohort AT christiancabnet longtermfollowupanalysisofassociationsbetweentoothlossandmultiplecancersinthelinxiangeneralpopulationcohort
_version_	1718405571504242688

A long-term follow-up analysis of associations between tooth loss and multiple cancers in the Linxian General Population cohort

Ejemplares similares