Prenatal exposure to bisphenols, immune responses in cord blood and infantile eczema: A nested prospective cohort study in China

Increasing evidence shows that human exposure to bisphenols can increase the risk of allergic disease, such as child asthma. However, the mechanism by which exposure to bisphenols causes allergic disease is unclear. In addition, the effects of exposure to bisphenols during pregnancy on infantile ecz...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xue-Ning Li, Dan Wu, Ying Liu, Shuang-Shuang Zhang, Fu-Lin Tian, Qi Sun, Wei Wei, Xia Cao, Li-Hong Jia
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Birth cohort Bisphenols Pregnant women Infant Eczema Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/d5c915ffa8294bf3a35aec03dab0d7ac
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d5c915ffa8294bf3a35aec03dab0d7ac
record_format	dspace
spelling	oai:doaj.org-article:d5c915ffa8294bf3a35aec03dab0d7ac2021-11-14T04:28:26ZPrenatal exposure to bisphenols, immune responses in cord blood and infantile eczema: A nested prospective cohort study in China0147-651310.1016/j.ecoenv.2021.112987https://doaj.org/article/d5c915ffa8294bf3a35aec03dab0d7ac2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S014765132101099Xhttps://doaj.org/toc/0147-6513Increasing evidence shows that human exposure to bisphenols can increase the risk of allergic disease, such as child asthma. However, the mechanism by which exposure to bisphenols causes allergic disease is unclear. In addition, the effects of exposure to bisphenols during pregnancy on infantile eczema have been poorly studied. The aim of our study was to investigate the effect of bisphenols (BPA, BPF and BPS) exposure during pregnancy on immune cells in cord blood, and on the occurrence of infantile eczema. 111 mother-child pairs with urine samples from pregnant women and cord blood were recruited from a birth cohort established in February 2019 in Shenyang, China. The levels of urinary bisphenols and Th1-, Th2-, Treg- and Th17-related genes, and cytokines in cord blood, as well as the incidence of infantile eczema at 6 and 12 months follow up were determined. Our results show that BPA, BPF and BPS were detected in 100%, 63.1% and 46.8% of the urine samples, respectively. The median concentration of urine specific gravity adjusted BPA (SG-BPA) was 7.46 ng/mL. High SG-BPA levels during pregnancy was independently associated with increased risk of infantile eczema (adjusted OR = 2.731, 95%CI: 1.064–7.012, P = 0.037). Higher levels of FOXP3 gene in cord blood had a significantly lower risk of developing eczema in infants (adjusted OR=0.430, 95%CI: 0.190–0.972, P = 0.042). However, BPS and BPF levels were not associated with infantile eczema. FOXP3 gene levels in cord blood mediated the relationship between SG-BPA levels during pregnancy and infantile eczema (indirect effect: β = 0.350 [CI:0.011,1.077]). Our findings indicate that high levels of BPA exposure during pregnancy increase the risk of infantile eczema, which may be associated with down-regulation of FOXP3 gene expression in cord blood.Xue-Ning LiDan WuYing LiuShuang-Shuang ZhangFu-Lin TianQi SunWei WeiXia CaoLi-Hong JiaElsevierarticleBirth cohortBisphenolsPregnant womenInfantEczemaEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 228, Iss , Pp 112987- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Birth cohort Bisphenols Pregnant women Infant Eczema Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Birth cohort Bisphenols Pregnant women Infant Eczema Environmental pollution TD172-193.5 Environmental sciences GE1-350 Xue-Ning Li Dan Wu Ying Liu Shuang-Shuang Zhang Fu-Lin Tian Qi Sun Wei Wei Xia Cao Li-Hong Jia Prenatal exposure to bisphenols, immune responses in cord blood and infantile eczema: A nested prospective cohort study in China
description	Increasing evidence shows that human exposure to bisphenols can increase the risk of allergic disease, such as child asthma. However, the mechanism by which exposure to bisphenols causes allergic disease is unclear. In addition, the effects of exposure to bisphenols during pregnancy on infantile eczema have been poorly studied. The aim of our study was to investigate the effect of bisphenols (BPA, BPF and BPS) exposure during pregnancy on immune cells in cord blood, and on the occurrence of infantile eczema. 111 mother-child pairs with urine samples from pregnant women and cord blood were recruited from a birth cohort established in February 2019 in Shenyang, China. The levels of urinary bisphenols and Th1-, Th2-, Treg- and Th17-related genes, and cytokines in cord blood, as well as the incidence of infantile eczema at 6 and 12 months follow up were determined. Our results show that BPA, BPF and BPS were detected in 100%, 63.1% and 46.8% of the urine samples, respectively. The median concentration of urine specific gravity adjusted BPA (SG-BPA) was 7.46 ng/mL. High SG-BPA levels during pregnancy was independently associated with increased risk of infantile eczema (adjusted OR = 2.731, 95%CI: 1.064–7.012, P = 0.037). Higher levels of FOXP3 gene in cord blood had a significantly lower risk of developing eczema in infants (adjusted OR=0.430, 95%CI: 0.190–0.972, P = 0.042). However, BPS and BPF levels were not associated with infantile eczema. FOXP3 gene levels in cord blood mediated the relationship between SG-BPA levels during pregnancy and infantile eczema (indirect effect: β = 0.350 [CI:0.011,1.077]). Our findings indicate that high levels of BPA exposure during pregnancy increase the risk of infantile eczema, which may be associated with down-regulation of FOXP3 gene expression in cord blood.
format	article
author	Xue-Ning Li Dan Wu Ying Liu Shuang-Shuang Zhang Fu-Lin Tian Qi Sun Wei Wei Xia Cao Li-Hong Jia
author_facet	Xue-Ning Li Dan Wu Ying Liu Shuang-Shuang Zhang Fu-Lin Tian Qi Sun Wei Wei Xia Cao Li-Hong Jia
author_sort	Xue-Ning Li
title	Prenatal exposure to bisphenols, immune responses in cord blood and infantile eczema: A nested prospective cohort study in China
title_short	Prenatal exposure to bisphenols, immune responses in cord blood and infantile eczema: A nested prospective cohort study in China
title_full	Prenatal exposure to bisphenols, immune responses in cord blood and infantile eczema: A nested prospective cohort study in China
title_fullStr	Prenatal exposure to bisphenols, immune responses in cord blood and infantile eczema: A nested prospective cohort study in China
title_full_unstemmed	Prenatal exposure to bisphenols, immune responses in cord blood and infantile eczema: A nested prospective cohort study in China
title_sort	prenatal exposure to bisphenols, immune responses in cord blood and infantile eczema: a nested prospective cohort study in china
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d5c915ffa8294bf3a35aec03dab0d7ac
work_keys_str_mv	AT xueningli prenatalexposuretobisphenolsimmuneresponsesincordbloodandinfantileeczemaanestedprospectivecohortstudyinchina AT danwu prenatalexposuretobisphenolsimmuneresponsesincordbloodandinfantileeczemaanestedprospectivecohortstudyinchina AT yingliu prenatalexposuretobisphenolsimmuneresponsesincordbloodandinfantileeczemaanestedprospectivecohortstudyinchina AT shuangshuangzhang prenatalexposuretobisphenolsimmuneresponsesincordbloodandinfantileeczemaanestedprospectivecohortstudyinchina AT fulintian prenatalexposuretobisphenolsimmuneresponsesincordbloodandinfantileeczemaanestedprospectivecohortstudyinchina AT qisun prenatalexposuretobisphenolsimmuneresponsesincordbloodandinfantileeczemaanestedprospectivecohortstudyinchina AT weiwei prenatalexposuretobisphenolsimmuneresponsesincordbloodandinfantileeczemaanestedprospectivecohortstudyinchina AT xiacao prenatalexposuretobisphenolsimmuneresponsesincordbloodandinfantileeczemaanestedprospectivecohortstudyinchina AT lihongjia prenatalexposuretobisphenolsimmuneresponsesincordbloodandinfantileeczemaanestedprospectivecohortstudyinchina
_version_	1718430045799710720

Prenatal exposure to bisphenols, immune responses in cord blood and infantile eczema: A nested prospective cohort study in China

Ejemplares similares