Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy

Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when exces...

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Autores principales:	Xinyuan Zhang, Kaiyue Wang, Ling Zhu, Qiyun Wang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/d5ca6af705484aa69bc910ac555ba320
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spelling	oai:doaj.org-article:d5ca6af705484aa69bc910ac555ba3202021-11-08T02:35:58ZReverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy2314-675310.1155/2021/8746114https://doaj.org/article/d5ca6af705484aa69bc910ac555ba3202021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8746114https://doaj.org/toc/2314-6753Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when excessive cholesterol is produced in the extrahepatic cells, which is regulated by the liver X receptor (LXR) and its downstream regulators ATP-binding cassette subfamily A member 1 (ABCA1) and ATP-binding cassette subfamily G member 1 (ABCG1) genes. Abnormal cholesterol metabolism is closely associated with the development of diabetic retinopathy (DR). However, the precise underlying mechanism of the RCT pathway in the pathogenesis of DR is still not fully understood. This review focused on cholesterol metabolism, with a particular emphasis on the RCT pathway and its correlation with the development of DR. Particular attention has been paid to the key regulators of the RCT pathway: LXR, ABCA1, and ABCG1 genes and their potential therapeutic targets in the management of DR.Xinyuan ZhangKaiyue WangLing ZhuQiyun WangHindawi LimitedarticleDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENJournal of Diabetes Research, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Diseases of the endocrine glands. Clinical endocrinology RC648-665 Xinyuan Zhang Kaiyue Wang Ling Zhu Qiyun Wang Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy
description	Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when excessive cholesterol is produced in the extrahepatic cells, which is regulated by the liver X receptor (LXR) and its downstream regulators ATP-binding cassette subfamily A member 1 (ABCA1) and ATP-binding cassette subfamily G member 1 (ABCG1) genes. Abnormal cholesterol metabolism is closely associated with the development of diabetic retinopathy (DR). However, the precise underlying mechanism of the RCT pathway in the pathogenesis of DR is still not fully understood. This review focused on cholesterol metabolism, with a particular emphasis on the RCT pathway and its correlation with the development of DR. Particular attention has been paid to the key regulators of the RCT pathway: LXR, ABCA1, and ABCG1 genes and their potential therapeutic targets in the management of DR.
format	article
author	Xinyuan Zhang Kaiyue Wang Ling Zhu Qiyun Wang
author_facet	Xinyuan Zhang Kaiyue Wang Ling Zhu Qiyun Wang
author_sort	Xinyuan Zhang
title	Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy
title_short	Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy
title_full	Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy
title_fullStr	Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy
title_full_unstemmed	Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy
title_sort	reverse cholesterol transport pathway and cholesterol efflux in diabetic retinopathy
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/d5ca6af705484aa69bc910ac555ba320
work_keys_str_mv	AT xinyuanzhang reversecholesteroltransportpathwayandcholesteroleffluxindiabeticretinopathy AT kaiyuewang reversecholesteroltransportpathwayandcholesteroleffluxindiabeticretinopathy AT lingzhu reversecholesteroltransportpathwayandcholesteroleffluxindiabeticretinopathy AT qiyunwang reversecholesteroltransportpathwayandcholesteroleffluxindiabeticretinopathy
_version_	1718443234136424448

Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy

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