Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway

Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway

Abstract Pancreas transcription factor 1 subunit alpha (PTF1A) is one of the key regulators in pancreatogenesis. In adults, it transcribes digestive enzymes, but its other functions remain largely unknown. Recent conditional knockout studies using Ptf1a CreER/floxed heterozygous mouse models have fo...

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Main Authors: Morito Sakikubo, Kenichiro Furuyama, Masashi Horiguchi, Shinichi Hosokawa, Yoshiki Aoyama, Kunihiko Tsuboi, Toshihiko Goto, Koji Hirata, Toshihiko Masui, Yuval Dor, Tomoyuki Fujiyama, Mikio Hoshino, Shinji Uemoto, Yoshiya Kawaguchi
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Adult Acinar Cells
C/EBP Homologous Protein (CHOP)
Inositol-requiring Enzyme 1 (IRE1)
IRE1 Pathway
ATF6 Pathway
Medicine
R
Science
Q
Online Access:https://doaj.org/article/d5cda09dbd034ebdab5ad4d1f0328baa
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https://doaj.org/article/d5cda09dbd034ebdab5ad4d1f0328baa

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