Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

Circular RNAs (circRNAs) are non-coding RNAs generated from pre-mRNAs of coding genes by the splicing machinery whose function in the heart is poorly understood. Here the authors show that AAV-mediated delivery of the circRNA circFndc3b prevents cardiomyocyte apoptosis, enhances angiogenesis, and at...

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Autores principales:	Venkata Naga Srikanth Garikipati, Suresh Kumar Verma, Zhongjian Cheng, Dongming Liang, May M. Truongcao, Maria Cimini, Yujia Yue, Grace Huang, Chunlin Wang, Cindy Benedict, Yan Tang, Vandana Mallaredy, Jessica Ibetti, Laurel Grisanti, Sarah M. Schumacher, Erhe Gao, Sudarsan Rajan, Jeremy E. Wilusz, David Goukassian, Steven R. Houser, Walter J. Koch, Raj Kishore
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d5d34ad17adb4becbc41b78b8495bb2e
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spelling	oai:doaj.org-article:d5d34ad17adb4becbc41b78b8495bb2e2021-12-02T17:02:07ZCircular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis10.1038/s41467-019-11777-72041-1723https://doaj.org/article/d5d34ad17adb4becbc41b78b8495bb2e2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11777-7https://doaj.org/toc/2041-1723Circular RNAs (circRNAs) are non-coding RNAs generated from pre-mRNAs of coding genes by the splicing machinery whose function in the heart is poorly understood. Here the authors show that AAV-mediated delivery of the circRNA circFndc3b prevents cardiomyocyte apoptosis, enhances angiogenesis, and attenuates LV dysfunction post-MI in mice by regulating FUS-VEGF-A signalling.Venkata Naga Srikanth GarikipatiSuresh Kumar VermaZhongjian ChengDongming LiangMay M. TruongcaoMaria CiminiYujia YueGrace HuangChunlin WangCindy BenedictYan TangVandana MallaredyJessica IbettiLaurel GrisantiSarah M. SchumacherErhe GaoSudarsan RajanJeremy E. WiluszDavid GoukassianSteven R. HouserWalter J. KochRaj KishoreNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Venkata Naga Srikanth Garikipati Suresh Kumar Verma Zhongjian Cheng Dongming Liang May M. Truongcao Maria Cimini Yujia Yue Grace Huang Chunlin Wang Cindy Benedict Yan Tang Vandana Mallaredy Jessica Ibetti Laurel Grisanti Sarah M. Schumacher Erhe Gao Sudarsan Rajan Jeremy E. Wilusz David Goukassian Steven R. Houser Walter J. Koch Raj Kishore Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis
description	Circular RNAs (circRNAs) are non-coding RNAs generated from pre-mRNAs of coding genes by the splicing machinery whose function in the heart is poorly understood. Here the authors show that AAV-mediated delivery of the circRNA circFndc3b prevents cardiomyocyte apoptosis, enhances angiogenesis, and attenuates LV dysfunction post-MI in mice by regulating FUS-VEGF-A signalling.
format	article
author	Venkata Naga Srikanth Garikipati Suresh Kumar Verma Zhongjian Cheng Dongming Liang May M. Truongcao Maria Cimini Yujia Yue Grace Huang Chunlin Wang Cindy Benedict Yan Tang Vandana Mallaredy Jessica Ibetti Laurel Grisanti Sarah M. Schumacher Erhe Gao Sudarsan Rajan Jeremy E. Wilusz David Goukassian Steven R. Houser Walter J. Koch Raj Kishore
author_facet	Venkata Naga Srikanth Garikipati Suresh Kumar Verma Zhongjian Cheng Dongming Liang May M. Truongcao Maria Cimini Yujia Yue Grace Huang Chunlin Wang Cindy Benedict Yan Tang Vandana Mallaredy Jessica Ibetti Laurel Grisanti Sarah M. Schumacher Erhe Gao Sudarsan Rajan Jeremy E. Wilusz David Goukassian Steven R. Houser Walter J. Koch Raj Kishore
author_sort	Venkata Naga Srikanth Garikipati
title	Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis
title_short	Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis
title_full	Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis
title_fullStr	Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis
title_full_unstemmed	Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis
title_sort	circular rna circfndc3b modulates cardiac repair after myocardial infarction via fus/vegf-a axis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d5d34ad17adb4becbc41b78b8495bb2e
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Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

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