Absence of CD36 alters systemic vitamin A homeostasis

Abstract Fatty acid translocase (CD36) is a scavenger receptor with multiple ligands and diverse physiological actions. We recently reported that alcohol-induced hepatic retinoid mobilization is impaired in Cd36 −/− mice, leading us to hypothesize that CD36 has a novel role in hepatic vitamin A mobi...

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Autores principales:	Michael J. Trites, Maria Febbraio, Robin D. Clugston
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d5d89f54a4c94c719defa568adf0b22a
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spelling	oai:doaj.org-article:d5d89f54a4c94c719defa568adf0b22a2021-12-02T15:10:05ZAbsence of CD36 alters systemic vitamin A homeostasis10.1038/s41598-020-77411-52045-2322https://doaj.org/article/d5d89f54a4c94c719defa568adf0b22a2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77411-5https://doaj.org/toc/2045-2322Abstract Fatty acid translocase (CD36) is a scavenger receptor with multiple ligands and diverse physiological actions. We recently reported that alcohol-induced hepatic retinoid mobilization is impaired in Cd36 −/− mice, leading us to hypothesize that CD36 has a novel role in hepatic vitamin A mobilization. Given the central role of the liver in systemic vitamin A homeostasis we also postulated that absence of CD36 would affect whole-body vitamin A homeostasis. We tested this hypothesis in aging wild type and Cd36 −/− mice, as well as mice fed a vitamin A-deficient diet. In agreement with our hypothesis, Cd36 −/− mice accumulated hepatic retinyl ester stores with age to a greater extent than wild type mice. However, contrary to expectations, Cd36 −/− mice consuming a vitamin A-deficient diet mobilized hepatic retinoid similar to wild type mice. Interestingly, we observed that Cd36 −/− mice had significantly reduced white adipose tissue retinoid levels compared to wild type mice. In conclusion, we demonstrate that the absence of CD36 alters whole-body vitamin A homeostasis and suggest that this phenotype is secondary to the impaired chylomicron metabolism previously reported in these mice.Michael J. TritesMaria FebbraioRobin D. ClugstonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Michael J. Trites Maria Febbraio Robin D. Clugston Absence of CD36 alters systemic vitamin A homeostasis
description	Abstract Fatty acid translocase (CD36) is a scavenger receptor with multiple ligands and diverse physiological actions. We recently reported that alcohol-induced hepatic retinoid mobilization is impaired in Cd36 −/− mice, leading us to hypothesize that CD36 has a novel role in hepatic vitamin A mobilization. Given the central role of the liver in systemic vitamin A homeostasis we also postulated that absence of CD36 would affect whole-body vitamin A homeostasis. We tested this hypothesis in aging wild type and Cd36 −/− mice, as well as mice fed a vitamin A-deficient diet. In agreement with our hypothesis, Cd36 −/− mice accumulated hepatic retinyl ester stores with age to a greater extent than wild type mice. However, contrary to expectations, Cd36 −/− mice consuming a vitamin A-deficient diet mobilized hepatic retinoid similar to wild type mice. Interestingly, we observed that Cd36 −/− mice had significantly reduced white adipose tissue retinoid levels compared to wild type mice. In conclusion, we demonstrate that the absence of CD36 alters whole-body vitamin A homeostasis and suggest that this phenotype is secondary to the impaired chylomicron metabolism previously reported in these mice.
format	article
author	Michael J. Trites Maria Febbraio Robin D. Clugston
author_facet	Michael J. Trites Maria Febbraio Robin D. Clugston
author_sort	Michael J. Trites
title	Absence of CD36 alters systemic vitamin A homeostasis
title_short	Absence of CD36 alters systemic vitamin A homeostasis
title_full	Absence of CD36 alters systemic vitamin A homeostasis
title_fullStr	Absence of CD36 alters systemic vitamin A homeostasis
title_full_unstemmed	Absence of CD36 alters systemic vitamin A homeostasis
title_sort	absence of cd36 alters systemic vitamin a homeostasis
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d5d89f54a4c94c719defa568adf0b22a
work_keys_str_mv	AT michaeljtrites absenceofcd36alterssystemicvitaminahomeostasis AT mariafebbraio absenceofcd36alterssystemicvitaminahomeostasis AT robindclugston absenceofcd36alterssystemicvitaminahomeostasis
_version_	1718387782076858368

Absence of CD36 alters systemic vitamin A homeostasis

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