Endogenous opioids regulate moment-to-moment neuronal communication and excitability

The endogenous opioid system regulates fear and anxiety, but the underlying cellular mechanism is unclear. Winterset al. shows that in the intercalated cells (ITC) of the amygdala, endogenous opioids suppress glutamatergic inputs via the δ-opioid receptor presynaptically, and reduce the excitability...

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Autores principales:	Bryony L. Winters, Gabrielle C. Gregoriou, Sarah A. Kissiwaa, Oliver A. Wells, Danashi I. Medagoda, Sam M. Hermes, Neil T. Burford, Andrew Alt, Sue A. Aicher, Elena E. Bagley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d5dae2c2b5f34eefb24b94cf971ec920
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spelling	oai:doaj.org-article:d5dae2c2b5f34eefb24b94cf971ec9202021-12-02T15:38:52ZEndogenous opioids regulate moment-to-moment neuronal communication and excitability10.1038/ncomms146112041-1723https://doaj.org/article/d5dae2c2b5f34eefb24b94cf971ec9202017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14611https://doaj.org/toc/2041-1723The endogenous opioid system regulates fear and anxiety, but the underlying cellular mechanism is unclear. Winterset al. shows that in the intercalated cells (ITC) of the amygdala, endogenous opioids suppress glutamatergic inputs via the δ-opioid receptor presynaptically, and reduce the excitability of ITCs via the μ-opioid receptor postsynaptically.Bryony L. WintersGabrielle C. GregoriouSarah A. KissiwaaOliver A. WellsDanashi I. MedagodaSam M. HermesNeil T. BurfordAndrew AltSue A. AicherElena E. BagleyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bryony L. Winters Gabrielle C. Gregoriou Sarah A. Kissiwaa Oliver A. Wells Danashi I. Medagoda Sam M. Hermes Neil T. Burford Andrew Alt Sue A. Aicher Elena E. Bagley Endogenous opioids regulate moment-to-moment neuronal communication and excitability
description	The endogenous opioid system regulates fear and anxiety, but the underlying cellular mechanism is unclear. Winterset al. shows that in the intercalated cells (ITC) of the amygdala, endogenous opioids suppress glutamatergic inputs via the δ-opioid receptor presynaptically, and reduce the excitability of ITCs via the μ-opioid receptor postsynaptically.
format	article
author	Bryony L. Winters Gabrielle C. Gregoriou Sarah A. Kissiwaa Oliver A. Wells Danashi I. Medagoda Sam M. Hermes Neil T. Burford Andrew Alt Sue A. Aicher Elena E. Bagley
author_facet	Bryony L. Winters Gabrielle C. Gregoriou Sarah A. Kissiwaa Oliver A. Wells Danashi I. Medagoda Sam M. Hermes Neil T. Burford Andrew Alt Sue A. Aicher Elena E. Bagley
author_sort	Bryony L. Winters
title	Endogenous opioids regulate moment-to-moment neuronal communication and excitability
title_short	Endogenous opioids regulate moment-to-moment neuronal communication and excitability
title_full	Endogenous opioids regulate moment-to-moment neuronal communication and excitability
title_fullStr	Endogenous opioids regulate moment-to-moment neuronal communication and excitability
title_full_unstemmed	Endogenous opioids regulate moment-to-moment neuronal communication and excitability
title_sort	endogenous opioids regulate moment-to-moment neuronal communication and excitability
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d5dae2c2b5f34eefb24b94cf971ec920
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Endogenous opioids regulate moment-to-moment neuronal communication and excitability

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