Mitochondrial-nuclear cross-talk in the human brain is modulated by cell type and perturbed in neurodegenerative disease

Fairbrother-Browne and collaborators analyze the relationship between nuclear and mitochondrial gene expression across the human brain and find correlation profiles that are governed by regional patterns. They show that these correlations are disrupted in neurodegenerative diseases, suggesting the r...

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Autores principales:	Aine Fairbrother-Browne, Aminah T. Ali, Regina H. Reynolds, Sonia Garcia-Ruiz, David Zhang, Zhongbo Chen, Mina Ryten, Alan Hodgkinson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d5dd7c062e3448ff913f17a96a81fd0a
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spelling	oai:doaj.org-article:d5dd7c062e3448ff913f17a96a81fd0a2021-11-07T12:20:10ZMitochondrial-nuclear cross-talk in the human brain is modulated by cell type and perturbed in neurodegenerative disease10.1038/s42003-021-02792-w2399-3642https://doaj.org/article/d5dd7c062e3448ff913f17a96a81fd0a2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02792-whttps://doaj.org/toc/2399-3642Fairbrother-Browne and collaborators analyze the relationship between nuclear and mitochondrial gene expression across the human brain and find correlation profiles that are governed by regional patterns. They show that these correlations are disrupted in neurodegenerative diseases, suggesting the relevance of mito-nuclear interactions for normal brain function.Aine Fairbrother-BrowneAminah T. AliRegina H. ReynoldsSonia Garcia-RuizDavid ZhangZhongbo ChenMina RytenAlan HodgkinsonNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Aine Fairbrother-Browne Aminah T. Ali Regina H. Reynolds Sonia Garcia-Ruiz David Zhang Zhongbo Chen Mina Ryten Alan Hodgkinson Mitochondrial-nuclear cross-talk in the human brain is modulated by cell type and perturbed in neurodegenerative disease
description	Fairbrother-Browne and collaborators analyze the relationship between nuclear and mitochondrial gene expression across the human brain and find correlation profiles that are governed by regional patterns. They show that these correlations are disrupted in neurodegenerative diseases, suggesting the relevance of mito-nuclear interactions for normal brain function.
format	article
author	Aine Fairbrother-Browne Aminah T. Ali Regina H. Reynolds Sonia Garcia-Ruiz David Zhang Zhongbo Chen Mina Ryten Alan Hodgkinson
author_facet	Aine Fairbrother-Browne Aminah T. Ali Regina H. Reynolds Sonia Garcia-Ruiz David Zhang Zhongbo Chen Mina Ryten Alan Hodgkinson
author_sort	Aine Fairbrother-Browne
title	Mitochondrial-nuclear cross-talk in the human brain is modulated by cell type and perturbed in neurodegenerative disease
title_short	Mitochondrial-nuclear cross-talk in the human brain is modulated by cell type and perturbed in neurodegenerative disease
title_full	Mitochondrial-nuclear cross-talk in the human brain is modulated by cell type and perturbed in neurodegenerative disease
title_fullStr	Mitochondrial-nuclear cross-talk in the human brain is modulated by cell type and perturbed in neurodegenerative disease
title_full_unstemmed	Mitochondrial-nuclear cross-talk in the human brain is modulated by cell type and perturbed in neurodegenerative disease
title_sort	mitochondrial-nuclear cross-talk in the human brain is modulated by cell type and perturbed in neurodegenerative disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d5dd7c062e3448ff913f17a96a81fd0a
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Mitochondrial-nuclear cross-talk in the human brain is modulated by cell type and perturbed in neurodegenerative disease

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