A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system
Abstract A new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer hydrogels was prepared. The polysaccharides inner core based on sodium alginate (SA) and carboxymethyl cellulose (CM...
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Nature Portfolio
2021
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oai:doaj.org-article:d5e38e4f473344f587f72bc8866841272021-12-02T17:39:30ZA double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system10.1038/s41598-021-88503-12045-2322https://doaj.org/article/d5e38e4f473344f587f72bc8866841272021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88503-1https://doaj.org/toc/2045-2322Abstract A new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer hydrogels was prepared. The polysaccharides inner core based on sodium alginate (SA) and carboxymethyl cellulose (CMC), was formed by physical crosslinking with pH-sensitive property. The synthetic polymer out-layer with enhanced stability was introduced by chemical crosslinking to eliminate the expansion of inner core and the diffusion of inner content. The physicochemical structure of the double-layer hydrogels was characterized. The drug-release results demonstrated that the sustained-release effect of the hydrogels for different model drugs could be regulated by changing the composition or thickness of the hydrogel layer. The significant sustained-release effect for BSA and indomethacin indicated that the bilayer hydrogel can be developed into a novel sustained delivery system for bioactive substance or drugs with potential applications in drugs and functional foods.Yan HuSheng HuShangwen ZhangSiyi DongJie HuLi KangXinzhou YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Medicine R Science Q |
| spellingShingle |
Medicine R Science Q Yan Hu Sheng Hu Shangwen Zhang Siyi Dong Jie Hu Li Kang Xinzhou Yang A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system |
| description |
Abstract A new double-layer, pH-sensitive, composite hydrogel sustained-release system based on polysaccharides and synthetic polymers with combined functions of different inner/outer hydrogels was prepared. The polysaccharides inner core based on sodium alginate (SA) and carboxymethyl cellulose (CMC), was formed by physical crosslinking with pH-sensitive property. The synthetic polymer out-layer with enhanced stability was introduced by chemical crosslinking to eliminate the expansion of inner core and the diffusion of inner content. The physicochemical structure of the double-layer hydrogels was characterized. The drug-release results demonstrated that the sustained-release effect of the hydrogels for different model drugs could be regulated by changing the composition or thickness of the hydrogel layer. The significant sustained-release effect for BSA and indomethacin indicated that the bilayer hydrogel can be developed into a novel sustained delivery system for bioactive substance or drugs with potential applications in drugs and functional foods. |
| format |
article |
| author |
Yan Hu Sheng Hu Shangwen Zhang Siyi Dong Jie Hu Li Kang Xinzhou Yang |
| author_facet |
Yan Hu Sheng Hu Shangwen Zhang Siyi Dong Jie Hu Li Kang Xinzhou Yang |
| author_sort |
Yan Hu |
| title |
A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system |
| title_short |
A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system |
| title_full |
A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system |
| title_fullStr |
A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system |
| title_full_unstemmed |
A double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system |
| title_sort |
double-layer hydrogel based on alginate-carboxymethyl cellulose and synthetic polymer as sustained drug delivery system |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/d5e38e4f473344f587f72bc886684127 |
| work_keys_str_mv |
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| _version_ |
1718379850949984256 |