DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats

Saideh Fakharzadeh,1–3 Somayeh Kalanaky,2 Maryam Hafizi,2 Mohammad Hassan Nazaran,2 Homeira Zardooz1,3 1Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Research and Development, Sodour Ahrar Shargh Company, Tehran,...

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Autores principales:	Fakharzadeh S, Kalanaky S, Hafizi M, Nazaran MH, Zardooz H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	DIBc Nanochelating technology metal organic framework diabetes streptozotocin high-fat diet Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d5e3bae89db7405dbb3cc62648515238
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spelling	oai:doaj.org-article:d5e3bae89db7405dbb3cc626485152382021-12-02T04:38:10ZDIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats1178-2013https://doaj.org/article/d5e3bae89db7405dbb3cc626485152382019-03-01T00:00:00Zhttps://www.dovepress.com/dibc-a-nanochelating-based-nano-metal-organic-framework-shows-anti-dia-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Saideh Fakharzadeh,1–3 Somayeh Kalanaky,2 Maryam Hafizi,2 Mohammad Hassan Nazaran,2 Homeira Zardooz1,3 1Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Research and Development, Sodour Ahrar Shargh Company, Tehran, Iran; 3Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Aims: Despite daily increase in diabetic patients in the world, currently approved medications for this disease, at best, only reduce its progression speed. Using novel technologies is a solution for synthetizing more efficient medicines. In the present study, we evaluated anti-diabetic effects of DIBc, a nano metal–organic framework, which is synthetized based on nanochelating technology.Methods: High-fat diet and streptozotocin-induced diabetic rats were treated by DIBc or metformin for 6 weeks.Results: DIBc decreased plasma glucose, triglyceride, cholesterol, high-density lipoprotein, and low-density lipoprotein compared with diabetic and metformin groups. In DIBc-treated rats, significant homeostasis model assessment of insulin resistance index, malondialdehyde, and tumor necrosis factor-α decrease was observed. H&E staining showed increased islet number and area in DIBc-treated rats compared with diabetic controls.Conclusion: The results showed anti-diabetic effects of nanochelating-based framework. So DIBc, as a nano structure, has the capacity to be evaluated in future studies as a novel anti-diabetic agent. Keywords: DIBc, nanochelating technology, metal organic framework, diabetes, streptozotocin, high-fat diet  Fakharzadeh SKalanaky SHafizi MNazaran MHZardooz HDove Medical PressarticleDIBcNanochelating technologymetal organic frameworkdiabetesstreptozotocinhigh-fat dietMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 2145-2156 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	DIBc Nanochelating technology metal organic framework diabetes streptozotocin high-fat diet Medicine (General) R5-920
spellingShingle	DIBc Nanochelating technology metal organic framework diabetes streptozotocin high-fat diet Medicine (General) R5-920 Fakharzadeh S Kalanaky S Hafizi M Nazaran MH Zardooz H DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats
description	Saideh Fakharzadeh,1–3 Somayeh Kalanaky,2 Maryam Hafizi,2 Mohammad Hassan Nazaran,2 Homeira Zardooz1,3 1Department of Physiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Research and Development, Sodour Ahrar Shargh Company, Tehran, Iran; 3Neurophysiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran Aims: Despite daily increase in diabetic patients in the world, currently approved medications for this disease, at best, only reduce its progression speed. Using novel technologies is a solution for synthetizing more efficient medicines. In the present study, we evaluated anti-diabetic effects of DIBc, a nano metal–organic framework, which is synthetized based on nanochelating technology.Methods: High-fat diet and streptozotocin-induced diabetic rats were treated by DIBc or metformin for 6 weeks.Results: DIBc decreased plasma glucose, triglyceride, cholesterol, high-density lipoprotein, and low-density lipoprotein compared with diabetic and metformin groups. In DIBc-treated rats, significant homeostasis model assessment of insulin resistance index, malondialdehyde, and tumor necrosis factor-α decrease was observed. H&E staining showed increased islet number and area in DIBc-treated rats compared with diabetic controls.Conclusion: The results showed anti-diabetic effects of nanochelating-based framework. So DIBc, as a nano structure, has the capacity to be evaluated in future studies as a novel anti-diabetic agent. Keywords: DIBc, nanochelating technology, metal organic framework, diabetes, streptozotocin, high-fat diet
format	article
author	Fakharzadeh S Kalanaky S Hafizi M Nazaran MH Zardooz H
author_facet	Fakharzadeh S Kalanaky S Hafizi M Nazaran MH Zardooz H
author_sort	Fakharzadeh S
title	DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats
title_short	DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats
title_full	DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats
title_fullStr	DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats
title_full_unstemmed	DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats
title_sort	dibc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/d5e3bae89db7405dbb3cc62648515238
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_version_	1718401154017132544

DIBc, a nanochelating-based nano metal-organic framework, shows anti-diabetic effects in high-fat diet and streptozotocin-induced diabetic rats

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