Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity

Aging usually comes associated with increased visceral fat accumulation, reaching even an obesity state, and favoring its associated comorbidities. One of the processes involved in aging is cellular senescence, which is highly dependent on the activity of the regulators of the cell cycle. The aim of...

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Autores principales:	Ignacio Colón-Mesa, Marta Fernández-Galilea, Neira Sáinz, Marta Lopez-Yus, Jose M. Artigas, José Miguel Arbonés-Mainar, Elisa Félix-Soriano, Xavier Escoté, María Jesús Moreno-Aliaga
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	aging obesity cell cycle p27 CDK2 cyclins Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/d5e411f979254a3e9f72e91c3d2c8d99
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spelling	oai:doaj.org-article:d5e411f979254a3e9f72e91c3d2c8d992021-11-11T17:13:30ZRegulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity10.3390/ijms2221117451422-00671661-6596https://doaj.org/article/d5e411f979254a3e9f72e91c3d2c8d992021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11745https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Aging usually comes associated with increased visceral fat accumulation, reaching even an obesity state, and favoring its associated comorbidities. One of the processes involved in aging is cellular senescence, which is highly dependent on the activity of the regulators of the cell cycle. The aim of this study was to analyze the changes in the expression of <i>p27</i> and <i>cdk2</i> in different adipose tissue depots during aging, as well as their regulation by obesity in mice. Changes in the expression of <i>p27</i> and <i>CDK2</i> in visceral and subcutaneous white adipose tissue (WAT) biopsies were also analyzed in a human cohort of obesity and type 2 diabetes. <i>p27</i>, but not <i>cdk2</i>, exhibits a lower expression in subcutaneous than in visceral WAT in mice and humans. <i>p27</i> is drastically downregulated by aging in subcutaneous WAT (scWAT), but not in gonadal WAT, of female mice. Obesity upregulates <i>p27</i> and <i>cdk2</i> expression in scWAT, but not in other fat depots of aged mice. In humans, a significant upregulation of <i>p27</i> was observed in visceral WAT of subjects with obesity. Taken together, these results show a differential adipose depot-dependent regulation of <i>p27</i> and <i>cdk2</i> in aging and obesity, suggesting that p27 and cdk2 could contribute to the adipose-tissue depot’s metabolic differences. Further studies are necessary to fully corroborate this hypothesis.Ignacio Colón-MesaMarta Fernández-GalileaNeira SáinzMarta Lopez-YusJose M. ArtigasJosé Miguel Arbonés-MainarElisa Félix-SorianoXavier EscotéMaría Jesús Moreno-AliagaMDPI AGarticleagingobesitycell cyclep27CDK2cyclinsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11745, p 11745 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging obesity cell cycle p27 CDK2 cyclins Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	aging obesity cell cycle p27 CDK2 cyclins Biology (General) QH301-705.5 Chemistry QD1-999 Ignacio Colón-Mesa Marta Fernández-Galilea Neira Sáinz Marta Lopez-Yus Jose M. Artigas José Miguel Arbonés-Mainar Elisa Félix-Soriano Xavier Escoté María Jesús Moreno-Aliaga Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity
description	Aging usually comes associated with increased visceral fat accumulation, reaching even an obesity state, and favoring its associated comorbidities. One of the processes involved in aging is cellular senescence, which is highly dependent on the activity of the regulators of the cell cycle. The aim of this study was to analyze the changes in the expression of <i>p27</i> and <i>cdk2</i> in different adipose tissue depots during aging, as well as their regulation by obesity in mice. Changes in the expression of <i>p27</i> and <i>CDK2</i> in visceral and subcutaneous white adipose tissue (WAT) biopsies were also analyzed in a human cohort of obesity and type 2 diabetes. <i>p27</i>, but not <i>cdk2</i>, exhibits a lower expression in subcutaneous than in visceral WAT in mice and humans. <i>p27</i> is drastically downregulated by aging in subcutaneous WAT (scWAT), but not in gonadal WAT, of female mice. Obesity upregulates <i>p27</i> and <i>cdk2</i> expression in scWAT, but not in other fat depots of aged mice. In humans, a significant upregulation of <i>p27</i> was observed in visceral WAT of subjects with obesity. Taken together, these results show a differential adipose depot-dependent regulation of <i>p27</i> and <i>cdk2</i> in aging and obesity, suggesting that p27 and cdk2 could contribute to the adipose-tissue depot’s metabolic differences. Further studies are necessary to fully corroborate this hypothesis.
format	article
author	Ignacio Colón-Mesa Marta Fernández-Galilea Neira Sáinz Marta Lopez-Yus Jose M. Artigas José Miguel Arbonés-Mainar Elisa Félix-Soriano Xavier Escoté María Jesús Moreno-Aliaga
author_facet	Ignacio Colón-Mesa Marta Fernández-Galilea Neira Sáinz Marta Lopez-Yus Jose M. Artigas José Miguel Arbonés-Mainar Elisa Félix-Soriano Xavier Escoté María Jesús Moreno-Aliaga
author_sort	Ignacio Colón-Mesa
title	Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity
title_short	Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity
title_full	Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity
title_fullStr	Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity
title_full_unstemmed	Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity
title_sort	regulation of p27 and cdk2 expression in different adipose tissue depots in aging and obesity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d5e411f979254a3e9f72e91c3d2c8d99
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Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity

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