A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division

A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division

PKCε is known to exert a role in genome protection by directly phosphorylating and switching the specificity of Aurora B. Here the authors identify SERBP1 as a parallel mitotic PKCε substrate controlling translation and ensuring the integrity of chromosome segregation and successful cell division.

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Autores principales: Silvia Martini, Khalil Davis, Rupert Faraway, Lisa Elze, Nicola Lockwood, Andrew Jones, Xiao Xie, Neil Q. McDonald, David J. Mann, Alan Armstrong, Jernej Ule, Peter J. Parker
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d5e625f8ebda47a580e2c0dff47b3aba
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spelling oai:doaj.org-article:d5e625f8ebda47a580e2c0dff47b3aba2021-11-28T12:32:21ZA genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division10.1038/s41467-021-27189-52041-1723https://doaj.org/article/d5e625f8ebda47a580e2c0dff47b3aba2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27189-5https://doaj.org/toc/2041-1723PKCε is known to exert a role in genome protection by directly phosphorylating and switching the specificity of Aurora B. Here the authors identify SERBP1 as a parallel mitotic PKCε substrate controlling translation and ensuring the integrity of chromosome segregation and successful cell division.Silvia MartiniKhalil DavisRupert FarawayLisa ElzeNicola LockwoodAndrew JonesXiao XieNeil Q. McDonaldDavid J. MannAlan ArmstrongJernej UlePeter J. ParkerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Silvia Martini
Khalil Davis
Rupert Faraway
Lisa Elze
Nicola Lockwood
Andrew Jones
Xiao Xie
Neil Q. McDonald
David J. Mann
Alan Armstrong
Jernej Ule
Peter J. Parker
A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division
description PKCε is known to exert a role in genome protection by directly phosphorylating and switching the specificity of Aurora B. Here the authors identify SERBP1 as a parallel mitotic PKCε substrate controlling translation and ensuring the integrity of chromosome segregation and successful cell division.
format article
author Silvia Martini
Khalil Davis
Rupert Faraway
Lisa Elze
Nicola Lockwood
Andrew Jones
Xiao Xie
Neil Q. McDonald
David J. Mann
Alan Armstrong
Jernej Ule
Peter J. Parker
author_facet Silvia Martini
Khalil Davis
Rupert Faraway
Lisa Elze
Nicola Lockwood
Andrew Jones
Xiao Xie
Neil Q. McDonald
David J. Mann
Alan Armstrong
Jernej Ule
Peter J. Parker
author_sort Silvia Martini
title A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division
title_short A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division
title_full A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division
title_fullStr A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division
title_full_unstemmed A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division
title_sort genetically-encoded crosslinker screen identifies serbp1 as a pkcε substrate influencing translation and cell division
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/d5e625f8ebda47a580e2c0dff47b3aba
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