Stability of membranous nanostructures: a possible key mechanism in cancer progression

Veronika Kralj-IglicBiomedical Research Group, Faculty of Health Sciences, University of Ljubljana, Zdravstvena 5, Ljubljana, SloveniaAbstract: Membranous nanostructures, such as nanovesicles and nanotubules, are an important pool of biological membranes. Recent results indicate that they constitute...

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Autor principal:	Kralj-Iglic V
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d5e77cfaa94a4220bcf3fb60873bbf73
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spelling	oai:doaj.org-article:d5e77cfaa94a4220bcf3fb60873bbf732021-12-02T06:25:31ZStability of membranous nanostructures: a possible key mechanism in cancer progression1176-91141178-2013https://doaj.org/article/d5e77cfaa94a4220bcf3fb60873bbf732012-07-01T00:00:00Zhttp://www.dovepress.com/stability-of-membranous-nanostructures-a-possible-key-mechanism-in-can-a10378https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Veronika Kralj-IglicBiomedical Research Group, Faculty of Health Sciences, University of Ljubljana, Zdravstvena 5, Ljubljana, SloveniaAbstract: Membranous nanostructures, such as nanovesicles and nanotubules, are an important pool of biological membranes. Recent results indicate that they constitute cell-cell communication systems and that cancer development is influenced by these systems. Nanovesicles that are pinched off from cancer cells can move within the circulation and interact with distant cells. It has been suggested and indicated by experimental evidence that nanovesicles can induce metastases from the primary tumor in this way. Therefore, it is of importance to understand better the mechanisms of membrane budding and vesiculation. Here, a theoretical description is presented concerning consistently related lateral membrane composition, orientational ordering of membrane constituents, and a stable shape of nanovesicles and nanotubules. It is shown that the character of stable nanostructures reflects the composition of the membrane and the intrinsic shape of its constituents. An extension of the fluid mosaic model of biological membranes is suggested by taking into account curvature-mediated orientational ordering of the membrane constituents on strongly anisotropically curved regions. Based on experimental data for artificial membranes, a possible antimetastatic effect of plasma constituents via mediation of attractive interaction between membranous structures is suggested. This mediated attractive interaction hypothetically suppresses nanovesiculation by causing adhesion of buds to the mother membrane and preventing them from being pinched off from the membrane.Keywords: nanovesicles, nanotubules, nanotubes, microvesicles, exosomes, metastasisKralj-Iglic VDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 3579-3596 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Kralj-Iglic V Stability of membranous nanostructures: a possible key mechanism in cancer progression
description	Veronika Kralj-IglicBiomedical Research Group, Faculty of Health Sciences, University of Ljubljana, Zdravstvena 5, Ljubljana, SloveniaAbstract: Membranous nanostructures, such as nanovesicles and nanotubules, are an important pool of biological membranes. Recent results indicate that they constitute cell-cell communication systems and that cancer development is influenced by these systems. Nanovesicles that are pinched off from cancer cells can move within the circulation and interact with distant cells. It has been suggested and indicated by experimental evidence that nanovesicles can induce metastases from the primary tumor in this way. Therefore, it is of importance to understand better the mechanisms of membrane budding and vesiculation. Here, a theoretical description is presented concerning consistently related lateral membrane composition, orientational ordering of membrane constituents, and a stable shape of nanovesicles and nanotubules. It is shown that the character of stable nanostructures reflects the composition of the membrane and the intrinsic shape of its constituents. An extension of the fluid mosaic model of biological membranes is suggested by taking into account curvature-mediated orientational ordering of the membrane constituents on strongly anisotropically curved regions. Based on experimental data for artificial membranes, a possible antimetastatic effect of plasma constituents via mediation of attractive interaction between membranous structures is suggested. This mediated attractive interaction hypothetically suppresses nanovesiculation by causing adhesion of buds to the mother membrane and preventing them from being pinched off from the membrane.Keywords: nanovesicles, nanotubules, nanotubes, microvesicles, exosomes, metastasis
format	article
author	Kralj-Iglic V
author_facet	Kralj-Iglic V
author_sort	Kralj-Iglic V
title	Stability of membranous nanostructures: a possible key mechanism in cancer progression
title_short	Stability of membranous nanostructures: a possible key mechanism in cancer progression
title_full	Stability of membranous nanostructures: a possible key mechanism in cancer progression
title_fullStr	Stability of membranous nanostructures: a possible key mechanism in cancer progression
title_full_unstemmed	Stability of membranous nanostructures: a possible key mechanism in cancer progression
title_sort	stability of membranous nanostructures: a possible key mechanism in cancer progression
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/d5e77cfaa94a4220bcf3fb60873bbf73
work_keys_str_mv	AT kraljiglicv stabilityofmembranousnanostructuresapossiblekeymechanismincancerprogression
_version_	1718399964071067648

Stability of membranous nanostructures: a possible key mechanism in cancer progression

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