ON THE POSSIBILITY OF USING CARBON ENTEROSORBENTS TO NORMALIZE CHOLESTEROL METABOLISM

The creation of effective drugs for the prevention and treatment of atherosclerosis is one of the urgent interdisciplinary tasks for modern chemistry and pharmacology. Given the role of hypercholesterolemia in the development of this disease, it is necessary to remove excess amounts of cholesterol f...

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Autores principales:	N. V. Sych, L. I. Kotyns’ka, V. M. Vikarchuk, I. A. Farbun
Formato:	article
Lenguaje:	EN RU UK
Publicado:	National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine. 2021
Materias:	cholesterol atherosclerosis low-density lipoprotein (ldl) enterosorbents metabolism. Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/d5e86438162e4c4bb06dc41b7e45c5ab
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spelling	oai:doaj.org-article:d5e86438162e4c4bb06dc41b7e45c5ab2021-11-03T16:59:21ZON THE POSSIBILITY OF USING CARBON ENTEROSORBENTS TO NORMALIZE CHOLESTEROL METABOLISM2410-77512410-776Xhttps://doaj.org/article/d5e86438162e4c4bb06dc41b7e45c5ab2021-08-01T00:00:00Zhttp://biotechnology.kiev.ua/images/4_2021/sych_4_2021.pdfhttps://doaj.org/toc/2410-7751https://doaj.org/toc/2410-776XThe creation of effective drugs for the prevention and treatment of atherosclerosis is one of the urgent interdisciplinary tasks for modern chemistry and pharmacology. Given the role of hypercholesterolemia in the development of this disease, it is necessary to remove excess amounts of cholesterol from the body. As an alternative to means of lowering total cholesterol and low-density lipoprotein (LDL) cholesterol, the possibility of using carbon enterosorbents for efferent therapy is considered. Aim. The purpose of the study was to evaluate the sorption capacity of the adsorbents developed by authors in terms of the possibility of cholesterol adsorption. Methods. Using the spectrophotometric method, the sorption of cholesterol on samples of adsorbents obtained by chemical activation of waste from the processing of lignocellulosic raw materials — dogwood and coffee residue has been studied. Results. A comparison of sorption isotherms with the isotherm obtained on the industrial adsorbent SORBEX has been performed. It was shown that the adsorption capacity of carbon adsorbents is primarily determined by their porous structure. The highest sorption values (7,3 mg/g) have been revealed by the sorption material obtained by chemical activation of cornel seed, an intermediate position (6,3 mg/g) is occupied by the adsorbent obtained from the coffee residue. Industrial carbon SORBEX has the lowest sorption values (5,3 mg/g). Conclusions. Calculations by Langmuir’s and Freundlich’s models testify about the accordance of the experimental data to Langmuir’s model. The use of the obtained activated carbons may be one of the effective alternative ways to lower blood cholesterol.N. V. SychL. I. Kotyns’kaV. M. VikarchukI. A. FarbunNational Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.articlecholesterolatherosclerosislow-density lipoprotein (ldl)enterosorbentsmetabolism.BiotechnologyTP248.13-248.65ENRUUKBiotechnologia Acta, Vol 14, Iss 4, Pp 64-69 (2021)
institution	DOAJ
collection	DOAJ
language	EN RU UK
topic	cholesterol atherosclerosis low-density lipoprotein (ldl) enterosorbents metabolism. Biotechnology TP248.13-248.65
spellingShingle	cholesterol atherosclerosis low-density lipoprotein (ldl) enterosorbents metabolism. Biotechnology TP248.13-248.65 N. V. Sych L. I. Kotyns’ka V. M. Vikarchuk I. A. Farbun ON THE POSSIBILITY OF USING CARBON ENTEROSORBENTS TO NORMALIZE CHOLESTEROL METABOLISM
description	The creation of effective drugs for the prevention and treatment of atherosclerosis is one of the urgent interdisciplinary tasks for modern chemistry and pharmacology. Given the role of hypercholesterolemia in the development of this disease, it is necessary to remove excess amounts of cholesterol from the body. As an alternative to means of lowering total cholesterol and low-density lipoprotein (LDL) cholesterol, the possibility of using carbon enterosorbents for efferent therapy is considered. Aim. The purpose of the study was to evaluate the sorption capacity of the adsorbents developed by authors in terms of the possibility of cholesterol adsorption. Methods. Using the spectrophotometric method, the sorption of cholesterol on samples of adsorbents obtained by chemical activation of waste from the processing of lignocellulosic raw materials — dogwood and coffee residue has been studied. Results. A comparison of sorption isotherms with the isotherm obtained on the industrial adsorbent SORBEX has been performed. It was shown that the adsorption capacity of carbon adsorbents is primarily determined by their porous structure. The highest sorption values (7,3 mg/g) have been revealed by the sorption material obtained by chemical activation of cornel seed, an intermediate position (6,3 mg/g) is occupied by the adsorbent obtained from the coffee residue. Industrial carbon SORBEX has the lowest sorption values (5,3 mg/g). Conclusions. Calculations by Langmuir’s and Freundlich’s models testify about the accordance of the experimental data to Langmuir’s model. The use of the obtained activated carbons may be one of the effective alternative ways to lower blood cholesterol.
format	article
author	N. V. Sych L. I. Kotyns’ka V. M. Vikarchuk I. A. Farbun
author_facet	N. V. Sych L. I. Kotyns’ka V. M. Vikarchuk I. A. Farbun
author_sort	N. V. Sych
title	ON THE POSSIBILITY OF USING CARBON ENTEROSORBENTS TO NORMALIZE CHOLESTEROL METABOLISM
title_short	ON THE POSSIBILITY OF USING CARBON ENTEROSORBENTS TO NORMALIZE CHOLESTEROL METABOLISM
title_full	ON THE POSSIBILITY OF USING CARBON ENTEROSORBENTS TO NORMALIZE CHOLESTEROL METABOLISM
title_fullStr	ON THE POSSIBILITY OF USING CARBON ENTEROSORBENTS TO NORMALIZE CHOLESTEROL METABOLISM
title_full_unstemmed	ON THE POSSIBILITY OF USING CARBON ENTEROSORBENTS TO NORMALIZE CHOLESTEROL METABOLISM
title_sort	on the possibility of using carbon enterosorbents to normalize cholesterol metabolism
publisher	National Academy of Sciences of Ukraine and Palladin Institute of Biochemistry of the National Academy of Sciences of Ukraine.
publishDate	2021
url	https://doaj.org/article/d5e86438162e4c4bb06dc41b7e45c5ab
work_keys_str_mv	AT nvsych onthepossibilityofusingcarbonenterosorbentstonormalizecholesterolmetabolism AT likotynska onthepossibilityofusingcarbonenterosorbentstonormalizecholesterolmetabolism AT vmvikarchuk onthepossibilityofusingcarbonenterosorbentstonormalizecholesterolmetabolism AT iafarbun onthepossibilityofusingcarbonenterosorbentstonormalizecholesterolmetabolism
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ON THE POSSIBILITY OF USING CARBON ENTEROSORBENTS TO NORMALIZE CHOLESTEROL METABOLISM

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