Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

Hutchinson–Gilford progeria syndrome causes premature aging. Here the authors show that activation of the DNA damage response at dysfunctional telomeres and transcription of telomeric non-coding RNAs contributes to the pathogenesis, which can be ameliorated by treatment with sequence-specific telome...

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Autores principales:	Julio Aguado, Agustin Sola-Carvajal, Valeria Cancila, Gwladys Revêchon, Peh Fern Ong, Corey Winston Jones-Weinert, Emelie Wallén Arzt, Giovanna Lattanzi, Oliver Dreesen, Claudio Tripodo, Francesca Rossiello, Maria Eriksson, Fabrizio d’Adda di Fagagna
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d5eb9edbff7e43f5b790e3b311b3399f
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spelling	oai:doaj.org-article:d5eb9edbff7e43f5b790e3b311b3399f2021-12-02T16:50:59ZInhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome10.1038/s41467-019-13018-32041-1723https://doaj.org/article/d5eb9edbff7e43f5b790e3b311b3399f2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13018-3https://doaj.org/toc/2041-1723Hutchinson–Gilford progeria syndrome causes premature aging. Here the authors show that activation of the DNA damage response at dysfunctional telomeres and transcription of telomeric non-coding RNAs contributes to the pathogenesis, which can be ameliorated by treatment with sequence-specific telomeric antisense oligonucleotides.Julio AguadoAgustin Sola-CarvajalValeria CancilaGwladys RevêchonPeh Fern OngCorey Winston Jones-WeinertEmelie Wallén ArztGiovanna LattanziOliver DreesenClaudio TripodoFrancesca RossielloMaria ErikssonFabrizio d’Adda di FagagnaNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Julio Aguado Agustin Sola-Carvajal Valeria Cancila Gwladys Revêchon Peh Fern Ong Corey Winston Jones-Weinert Emelie Wallén Arzt Giovanna Lattanzi Oliver Dreesen Claudio Tripodo Francesca Rossiello Maria Eriksson Fabrizio d’Adda di Fagagna Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
description	Hutchinson–Gilford progeria syndrome causes premature aging. Here the authors show that activation of the DNA damage response at dysfunctional telomeres and transcription of telomeric non-coding RNAs contributes to the pathogenesis, which can be ameliorated by treatment with sequence-specific telomeric antisense oligonucleotides.
format	article
author	Julio Aguado Agustin Sola-Carvajal Valeria Cancila Gwladys Revêchon Peh Fern Ong Corey Winston Jones-Weinert Emelie Wallén Arzt Giovanna Lattanzi Oliver Dreesen Claudio Tripodo Francesca Rossiello Maria Eriksson Fabrizio d’Adda di Fagagna
author_facet	Julio Aguado Agustin Sola-Carvajal Valeria Cancila Gwladys Revêchon Peh Fern Ong Corey Winston Jones-Weinert Emelie Wallén Arzt Giovanna Lattanzi Oliver Dreesen Claudio Tripodo Francesca Rossiello Maria Eriksson Fabrizio d’Adda di Fagagna
author_sort	Julio Aguado
title	Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
title_short	Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
title_full	Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
title_fullStr	Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
title_full_unstemmed	Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome
title_sort	inhibition of dna damage response at telomeres improves the detrimental phenotypes of hutchinson–gilford progeria syndrome
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d5eb9edbff7e43f5b790e3b311b3399f
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Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson–Gilford Progeria Syndrome

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