Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures

Nanopore sequencing allows users to identify nucleotide sequence from ionic currents. Here, the authors use deep learning to facilitate the de novo identification of modified nucleotides, particularly methylated cytosine and guanine, from the measured ionic currents without the need for controls.

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Autores principales: Hongxu Ding, Ioannis Anastopoulos, Andrew D. Bailey, Joshua Stuart, Benedict Paten
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/d5ed7a8399bc4a528ffb86cdb93210db
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spelling oai:doaj.org-article:d5ed7a8399bc4a528ffb86cdb93210db2021-11-14T12:36:47ZTowards inferring nanopore sequencing ionic currents from nucleotide chemical structures10.1038/s41467-021-26929-x2041-1723https://doaj.org/article/d5ed7a8399bc4a528ffb86cdb93210db2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26929-xhttps://doaj.org/toc/2041-1723Nanopore sequencing allows users to identify nucleotide sequence from ionic currents. Here, the authors use deep learning to facilitate the de novo identification of modified nucleotides, particularly methylated cytosine and guanine, from the measured ionic currents without the need for controls.Hongxu DingIoannis AnastopoulosAndrew D. BaileyJoshua StuartBenedict PatenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Hongxu Ding
Ioannis Anastopoulos
Andrew D. Bailey
Joshua Stuart
Benedict Paten
Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures
description Nanopore sequencing allows users to identify nucleotide sequence from ionic currents. Here, the authors use deep learning to facilitate the de novo identification of modified nucleotides, particularly methylated cytosine and guanine, from the measured ionic currents without the need for controls.
format article
author Hongxu Ding
Ioannis Anastopoulos
Andrew D. Bailey
Joshua Stuart
Benedict Paten
author_facet Hongxu Ding
Ioannis Anastopoulos
Andrew D. Bailey
Joshua Stuart
Benedict Paten
author_sort Hongxu Ding
title Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures
title_short Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures
title_full Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures
title_fullStr Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures
title_full_unstemmed Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures
title_sort towards inferring nanopore sequencing ionic currents from nucleotide chemical structures
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/d5ed7a8399bc4a528ffb86cdb93210db
work_keys_str_mv AT hongxuding towardsinferringnanoporesequencingioniccurrentsfromnucleotidechemicalstructures
AT ioannisanastopoulos towardsinferringnanoporesequencingioniccurrentsfromnucleotidechemicalstructures
AT andrewdbailey towardsinferringnanoporesequencingioniccurrentsfromnucleotidechemicalstructures
AT joshuastuart towardsinferringnanoporesequencingioniccurrentsfromnucleotidechemicalstructures
AT benedictpaten towardsinferringnanoporesequencingioniccurrentsfromnucleotidechemicalstructures
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