Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures
Nanopore sequencing allows users to identify nucleotide sequence from ionic currents. Here, the authors use deep learning to facilitate the de novo identification of modified nucleotides, particularly methylated cytosine and guanine, from the measured ionic currents without the need for controls.
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Nature Portfolio
2021
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oai:doaj.org-article:d5ed7a8399bc4a528ffb86cdb93210db2021-11-14T12:36:47ZTowards inferring nanopore sequencing ionic currents from nucleotide chemical structures10.1038/s41467-021-26929-x2041-1723https://doaj.org/article/d5ed7a8399bc4a528ffb86cdb93210db2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26929-xhttps://doaj.org/toc/2041-1723Nanopore sequencing allows users to identify nucleotide sequence from ionic currents. Here, the authors use deep learning to facilitate the de novo identification of modified nucleotides, particularly methylated cytosine and guanine, from the measured ionic currents without the need for controls.Hongxu DingIoannis AnastopoulosAndrew D. BaileyJoshua StuartBenedict PatenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021) |
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Science Q Hongxu Ding Ioannis Anastopoulos Andrew D. Bailey Joshua Stuart Benedict Paten Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures |
description |
Nanopore sequencing allows users to identify nucleotide sequence from ionic currents. Here, the authors use deep learning to facilitate the de novo identification of modified nucleotides, particularly methylated cytosine and guanine, from the measured ionic currents without the need for controls. |
format |
article |
author |
Hongxu Ding Ioannis Anastopoulos Andrew D. Bailey Joshua Stuart Benedict Paten |
author_facet |
Hongxu Ding Ioannis Anastopoulos Andrew D. Bailey Joshua Stuart Benedict Paten |
author_sort |
Hongxu Ding |
title |
Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures |
title_short |
Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures |
title_full |
Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures |
title_fullStr |
Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures |
title_full_unstemmed |
Towards inferring nanopore sequencing ionic currents from nucleotide chemical structures |
title_sort |
towards inferring nanopore sequencing ionic currents from nucleotide chemical structures |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/d5ed7a8399bc4a528ffb86cdb93210db |
work_keys_str_mv |
AT hongxuding towardsinferringnanoporesequencingioniccurrentsfromnucleotidechemicalstructures AT ioannisanastopoulos towardsinferringnanoporesequencingioniccurrentsfromnucleotidechemicalstructures AT andrewdbailey towardsinferringnanoporesequencingioniccurrentsfromnucleotidechemicalstructures AT joshuastuart towardsinferringnanoporesequencingioniccurrentsfromnucleotidechemicalstructures AT benedictpaten towardsinferringnanoporesequencingioniccurrentsfromnucleotidechemicalstructures |
_version_ |
1718429135846506496 |