Photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection

Su-Eon Jin,1 Jun Eon Jin,2 Woochul Hwang,3 Seok Won Hong4 1Research Institute for Medical Sciences, College of Medicine, Inha University, Incheon 22212, Korea; 2College of Electrical Engineering, Korea University, Seoul 02841, Korea; 3ECOSET Co., Ltd., Ansan 15610, Korea; 4Korea Institute of Scienc...

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Autores principales:	Jin SE, Jin JE, Hwang W, Hong SW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	zinc oxide nanoparticle immobilization antibacterial disinfection toxicity Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/d5f0121c1dad49ea8c58c8c7b2cc5438
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spelling	oai:doaj.org-article:d5f0121c1dad49ea8c58c8c7b2cc54382021-12-02T08:45:24ZPhotocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection1178-2013https://doaj.org/article/d5f0121c1dad49ea8c58c8c7b2cc54382019-03-01T00:00:00Zhttps://www.dovepress.com/photocatalytic-antibacterial-application-of-zinc-oxide-nanoparticles-a-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Su-Eon Jin,1 Jun Eon Jin,2 Woochul Hwang,3 Seok Won Hong4 1Research Institute for Medical Sciences, College of Medicine, Inha University, Incheon 22212, Korea; 2College of Electrical Engineering, Korea University, Seoul 02841, Korea; 3ECOSET Co., Ltd., Ansan 15610, Korea; 4Korea Institute of Science and Technology, Seoul 02792, Korea Background: Zinc oxide (ZnO) nanoparticles and their networks have been developed for use in various applications such as gas sensors and semiconductors. Aim: In this study, their antibacterial activity against Escherichia coli under dual ultraviolet (UV) irradiation for disinfection was investigated. Materials and methods: ZnO nanoparticles were synthesized and immobilized onto silicon (Si) wafers by self-assembly. The physicochemical properties and antibacterial activity of ZnO nanoparticles and their networks were evaluated. Gene ontology was analyzed and toxicity levels were also monitored. Results: Synthesized ZnO nanoparticles were spherical nanocrystals (<100 nm; Zn, 47%; O,53%) that formed macro-mesoporous three-dimensional nanostructures on Si wafers in a concentration-dependent manner. ZnO nanoparticles and their networks on Si wafers had an excellent antibacterial activity against E. coli under dual UV irradiation (>3log CFU/ml). Specifically, arrayed ZnO nanoparticle networks showed superior activity compared with free synthesized ZnO nanoparticles. Oxidative stress-responsive proteins in E. coli were identified and categorized, which indicated antibacterial activity. Synthesized ZnO nanoparticles were less cytotoxic in HaCaT with an IC50 of 6.632 mg/mL, but phototoxic in Balb/c 3T3. Conclusion: The results suggested that ZnO nanoparticles and their networks can be promising photocatalytic antibiotics for use in next-generation disinfection systems. Their application could also be extended to industrial and clinical use as effective and safe photocatalytic antibiotics. Keywords: zinc oxide nanoparticles, immobilization, dual UV, antibacterial, disinfection, toxicityJin SEJin JEHwang WHong SWDove Medical Pressarticlezinc oxide nanoparticleimmobilizationantibacterialdisinfectiontoxicityMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 14, Pp 1737-1751 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	zinc oxide nanoparticle immobilization antibacterial disinfection toxicity Medicine (General) R5-920
spellingShingle	zinc oxide nanoparticle immobilization antibacterial disinfection toxicity Medicine (General) R5-920 Jin SE Jin JE Hwang W Hong SW Photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection
description	Su-Eon Jin,1 Jun Eon Jin,2 Woochul Hwang,3 Seok Won Hong4 1Research Institute for Medical Sciences, College of Medicine, Inha University, Incheon 22212, Korea; 2College of Electrical Engineering, Korea University, Seoul 02841, Korea; 3ECOSET Co., Ltd., Ansan 15610, Korea; 4Korea Institute of Science and Technology, Seoul 02792, Korea Background: Zinc oxide (ZnO) nanoparticles and their networks have been developed for use in various applications such as gas sensors and semiconductors. Aim: In this study, their antibacterial activity against Escherichia coli under dual ultraviolet (UV) irradiation for disinfection was investigated. Materials and methods: ZnO nanoparticles were synthesized and immobilized onto silicon (Si) wafers by self-assembly. The physicochemical properties and antibacterial activity of ZnO nanoparticles and their networks were evaluated. Gene ontology was analyzed and toxicity levels were also monitored. Results: Synthesized ZnO nanoparticles were spherical nanocrystals (<100 nm; Zn, 47%; O,53%) that formed macro-mesoporous three-dimensional nanostructures on Si wafers in a concentration-dependent manner. ZnO nanoparticles and their networks on Si wafers had an excellent antibacterial activity against E. coli under dual UV irradiation (>3log CFU/ml). Specifically, arrayed ZnO nanoparticle networks showed superior activity compared with free synthesized ZnO nanoparticles. Oxidative stress-responsive proteins in E. coli were identified and categorized, which indicated antibacterial activity. Synthesized ZnO nanoparticles were less cytotoxic in HaCaT with an IC50 of 6.632 mg/mL, but phototoxic in Balb/c 3T3. Conclusion: The results suggested that ZnO nanoparticles and their networks can be promising photocatalytic antibiotics for use in next-generation disinfection systems. Their application could also be extended to industrial and clinical use as effective and safe photocatalytic antibiotics. Keywords: zinc oxide nanoparticles, immobilization, dual UV, antibacterial, disinfection, toxicity
format	article
author	Jin SE Jin JE Hwang W Hong SW
author_facet	Jin SE Jin JE Hwang W Hong SW
author_sort	Jin SE
title	Photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection
title_short	Photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection
title_full	Photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection
title_fullStr	Photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection
title_full_unstemmed	Photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection
title_sort	photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual uv irradiation for enhanced disinfection
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/d5f0121c1dad49ea8c58c8c7b2cc5438
work_keys_str_mv	AT jinse photocatalyticantibacterialapplicationofzincoxidenanoparticlesandselfassemblednetworksunderdualuvirradiationforenhanceddisinfection AT jinje photocatalyticantibacterialapplicationofzincoxidenanoparticlesandselfassemblednetworksunderdualuvirradiationforenhanceddisinfection AT hwangw photocatalyticantibacterialapplicationofzincoxidenanoparticlesandselfassemblednetworksunderdualuvirradiationforenhanceddisinfection AT hongsw photocatalyticantibacterialapplicationofzincoxidenanoparticlesandselfassemblednetworksunderdualuvirradiationforenhanceddisinfection
_version_	1718398393347211264

Photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection

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