Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies

Cancer is one of the major maladies affecting humankind and remains one of the leading causes of death worldwide. The investigation of the biological activities of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties, especially in the research o...

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Autores principales:	Francisco Assis Nascimento Pereira, Josianne Rocha Barboza, Cleydlenne Costa Vasconcelos, Alberto Jorge Oliveira Lopes, Maria Nilce de Sousa Ribeiro
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	stingless bee products new anticancer agents propolis geopropolis Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/d5f44f2ab8894c84950498fee4c58b02
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spelling	oai:doaj.org-article:d5f44f2ab8894c84950498fee4c58b022021-11-25T18:39:50ZUse of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies10.3390/ph141111611424-8247https://doaj.org/article/d5f44f2ab8894c84950498fee4c58b022021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1161https://doaj.org/toc/1424-8247Cancer is one of the major maladies affecting humankind and remains one of the leading causes of death worldwide. The investigation of the biological activities of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties, especially in the research on new antineoplastic agents. This literature review of preclinical trials, involving biological assays of antitumor activity and identification of the chemical composition of propolis and geopropolis of stingless bee species, describes the cytotoxicity in tumor lineages (breast, lung, ovarian, liver, mouth, pharynx, larynx, colon, stomach, colorectal, cervix, kidney, prostate, melanoma, human glioblastoma, canine osteosarcoma, erythroleukemia, human chronic myelocytic leukemia, and human promyelocytic leukemia) of propolis and geopropolis of 33 species of stingless bees. The chemical composition of propolis and geopropolis was identified, indicating that these belong to the chemical classes of phenolic acids, flavonoids, coumarins, benzophenones, anthraquinones, alkaloids, terpenes, steroids, saponins, fatty acids, and carbohydrates and are possibly responsible for the cytotoxicity in tumor cells. Apoptosis was one of the main mechanisms of cytotoxicity of extracts and substances isolated from stingless bee products. Although the results found are encouraging, other preclinical studies and clinical trials are essential for the discovery of new anticancer agents.Francisco Assis Nascimento PereiraJosianne Rocha BarbozaCleydlenne Costa VasconcelosAlberto Jorge Oliveira LopesMaria Nilce de Sousa RibeiroMDPI AGarticlestingless bee productsnew anticancer agentspropolisgeopropolisMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1161, p 1161 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	stingless bee products new anticancer agents propolis geopropolis Medicine R Pharmacy and materia medica RS1-441
spellingShingle	stingless bee products new anticancer agents propolis geopropolis Medicine R Pharmacy and materia medica RS1-441 Francisco Assis Nascimento Pereira Josianne Rocha Barboza Cleydlenne Costa Vasconcelos Alberto Jorge Oliveira Lopes Maria Nilce de Sousa Ribeiro Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
description	Cancer is one of the major maladies affecting humankind and remains one of the leading causes of death worldwide. The investigation of the biological activities of stingless bee products, especially propolis and geopropolis, has revealed promising therapeutic properties, especially in the research on new antineoplastic agents. This literature review of preclinical trials, involving biological assays of antitumor activity and identification of the chemical composition of propolis and geopropolis of stingless bee species, describes the cytotoxicity in tumor lineages (breast, lung, ovarian, liver, mouth, pharynx, larynx, colon, stomach, colorectal, cervix, kidney, prostate, melanoma, human glioblastoma, canine osteosarcoma, erythroleukemia, human chronic myelocytic leukemia, and human promyelocytic leukemia) of propolis and geopropolis of 33 species of stingless bees. The chemical composition of propolis and geopropolis was identified, indicating that these belong to the chemical classes of phenolic acids, flavonoids, coumarins, benzophenones, anthraquinones, alkaloids, terpenes, steroids, saponins, fatty acids, and carbohydrates and are possibly responsible for the cytotoxicity in tumor cells. Apoptosis was one of the main mechanisms of cytotoxicity of extracts and substances isolated from stingless bee products. Although the results found are encouraging, other preclinical studies and clinical trials are essential for the discovery of new anticancer agents.
format	article
author	Francisco Assis Nascimento Pereira Josianne Rocha Barboza Cleydlenne Costa Vasconcelos Alberto Jorge Oliveira Lopes Maria Nilce de Sousa Ribeiro
author_facet	Francisco Assis Nascimento Pereira Josianne Rocha Barboza Cleydlenne Costa Vasconcelos Alberto Jorge Oliveira Lopes Maria Nilce de Sousa Ribeiro
author_sort	Francisco Assis Nascimento Pereira
title	Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
title_short	Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
title_full	Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
title_fullStr	Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
title_full_unstemmed	Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies
title_sort	use of stingless bee propolis and geopropolis against cancer—a literature review of preclinical studies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d5f44f2ab8894c84950498fee4c58b02
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Use of Stingless Bee Propolis and Geopropolis against Cancer—A Literature Review of Preclinical Studies

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