Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid
Objective: Cigarette smoking might accelerate cognitive impairment; however, this has never been investigated using human cerebrospinal fluid (CSF). We conducted this study to investigate the association between cigarette smoking and cognitive impairment through metal ions in CSF.Methods: We obtaine...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:d5f56cf38c9042ba8bff6453ebf43ff92021-11-30T14:14:36ZAssociation of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid1664-064010.3389/fpsyt.2021.738358https://doaj.org/article/d5f56cf38c9042ba8bff6453ebf43ff92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpsyt.2021.738358/fullhttps://doaj.org/toc/1664-0640Objective: Cigarette smoking might accelerate cognitive impairment; however, this has never been investigated using human cerebrospinal fluid (CSF). We conducted this study to investigate the association between cigarette smoking and cognitive impairment through metal ions in CSF.Methods: We obtained 5-ml CSF samples from routine lumbar puncture procedures in patients undergoing anterior cruciate ligament reconstruction before surgery in China. A total of 180 Chinese males were recruited (80 active smokers and 100 non-smokers). We measured specific cigarette-related neurotoxic metal ions in CSF, including iron, copper, zinc, lead, aluminum, and manganese. Sociodemographic data and history of smoking were obtained. The Montreal Cognitive Assessment (MoCA) was applied.Results: Active smokers had fewer years of education (11.83 ± 3.13 vs. 13.17 ± 2.60, p = 0.01), and higher age (33.70 ± 10.20 vs. 29.76 ± 9.58, p = 0.01) and body mass index (25.84 ± 3.52 vs. 24.98 ± 4.06, p =0.03) than non-smokers. Compared to non-smokers, active smokers had significantly higher CSF levels of iron, zinc, lead, and aluminum and lower MoCA scores (all p < 0.05). Average daily numbers of cigarettes smoked negatively correlated with the MoCA scores (r = −0.244, p = 0.048). In young smokers, CSF manganese levels negatively correlated with MoCA scores (r = −0.373, p = 0.009).Conclusions and Relevance: Cigarette smoking might be associated with male cognitive impairment, as shown by lower MoCA scores and higher levels of CSF iron, zinc, lead, and aluminum in active smokers. This might be early evidence of cigarette smoking accelerating male cognitive impairment.Hui LiHui LiQingshuang MuYimin KangXiaoyu YangLigang ShanMeiling WangCunbao LiYanlong LiuYanlong LiuFan WangFrontiers Media S.A.articlecigarette smokingcognitive impairmentmetal ioncerebrospinal fluidmalePsychiatryRC435-571ENFrontiers in Psychiatry, Vol 12 (2021) |
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| topic |
cigarette smoking cognitive impairment metal ion cerebrospinal fluid male Psychiatry RC435-571 |
| spellingShingle |
cigarette smoking cognitive impairment metal ion cerebrospinal fluid male Psychiatry RC435-571 Hui Li Hui Li Qingshuang Mu Yimin Kang Xiaoyu Yang Ligang Shan Meiling Wang Cunbao Li Yanlong Liu Yanlong Liu Fan Wang Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid |
| description |
Objective: Cigarette smoking might accelerate cognitive impairment; however, this has never been investigated using human cerebrospinal fluid (CSF). We conducted this study to investigate the association between cigarette smoking and cognitive impairment through metal ions in CSF.Methods: We obtained 5-ml CSF samples from routine lumbar puncture procedures in patients undergoing anterior cruciate ligament reconstruction before surgery in China. A total of 180 Chinese males were recruited (80 active smokers and 100 non-smokers). We measured specific cigarette-related neurotoxic metal ions in CSF, including iron, copper, zinc, lead, aluminum, and manganese. Sociodemographic data and history of smoking were obtained. The Montreal Cognitive Assessment (MoCA) was applied.Results: Active smokers had fewer years of education (11.83 ± 3.13 vs. 13.17 ± 2.60, p = 0.01), and higher age (33.70 ± 10.20 vs. 29.76 ± 9.58, p = 0.01) and body mass index (25.84 ± 3.52 vs. 24.98 ± 4.06, p =0.03) than non-smokers. Compared to non-smokers, active smokers had significantly higher CSF levels of iron, zinc, lead, and aluminum and lower MoCA scores (all p < 0.05). Average daily numbers of cigarettes smoked negatively correlated with the MoCA scores (r = −0.244, p = 0.048). In young smokers, CSF manganese levels negatively correlated with MoCA scores (r = −0.373, p = 0.009).Conclusions and Relevance: Cigarette smoking might be associated with male cognitive impairment, as shown by lower MoCA scores and higher levels of CSF iron, zinc, lead, and aluminum in active smokers. This might be early evidence of cigarette smoking accelerating male cognitive impairment. |
| format |
article |
| author |
Hui Li Hui Li Qingshuang Mu Yimin Kang Xiaoyu Yang Ligang Shan Meiling Wang Cunbao Li Yanlong Liu Yanlong Liu Fan Wang |
| author_facet |
Hui Li Hui Li Qingshuang Mu Yimin Kang Xiaoyu Yang Ligang Shan Meiling Wang Cunbao Li Yanlong Liu Yanlong Liu Fan Wang |
| author_sort |
Hui Li |
| title |
Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid |
| title_short |
Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid |
| title_full |
Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid |
| title_fullStr |
Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid |
| title_full_unstemmed |
Association of Cigarette Smoking With Male Cognitive Impairment and Metal Ions in Cerebrospinal Fluid |
| title_sort |
association of cigarette smoking with male cognitive impairment and metal ions in cerebrospinal fluid |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/d5f56cf38c9042ba8bff6453ebf43ff9 |
| work_keys_str_mv |
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