Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency

Bajrami, Walker et al. investigated the synthetic lethality between BRCA gene defects and inhibition of two sirtuin genes, SIRT1 or SIRT6, which was found to be associated with replication stress and increased PARylation. The authors demonstrated that the SIRT/BRCA1 synthetic lethality was reversed...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ilirjana Bajrami, Callum Walker, Dragomir B. Krastev, Daniel Weekes, Feifei Song, Andrew J. Wicks, John Alexander, Syed Haider, Rachel Brough, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d5f5e8c9681d4c1cb2934f06ed9a1386
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d5f5e8c9681d4c1cb2934f06ed9a1386
record_format	dspace
spelling	oai:doaj.org-article:d5f5e8c9681d4c1cb2934f06ed9a13862021-11-14T12:12:07ZSirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency10.1038/s42003-021-02770-22399-3642https://doaj.org/article/d5f5e8c9681d4c1cb2934f06ed9a13862021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02770-2https://doaj.org/toc/2399-3642Bajrami, Walker et al. investigated the synthetic lethality between BRCA gene defects and inhibition of two sirtuin genes, SIRT1 or SIRT6, which was found to be associated with replication stress and increased PARylation. The authors demonstrated that the SIRT/BRCA1 synthetic lethality was reversed by genetic ablation of PARP1 or HPF1.Ilirjana BajramiCallum WalkerDragomir B. KrastevDaniel WeekesFeifei SongAndrew J. WicksJohn AlexanderSyed HaiderRachel BroughStephen J. PettittAndrew N. J. TuttChristopher J. LordNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Ilirjana Bajrami Callum Walker Dragomir B. Krastev Daniel Weekes Feifei Song Andrew J. Wicks John Alexander Syed Haider Rachel Brough Stephen J. Pettitt Andrew N. J. Tutt Christopher J. Lord Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
description	Bajrami, Walker et al. investigated the synthetic lethality between BRCA gene defects and inhibition of two sirtuin genes, SIRT1 or SIRT6, which was found to be associated with replication stress and increased PARylation. The authors demonstrated that the SIRT/BRCA1 synthetic lethality was reversed by genetic ablation of PARP1 or HPF1.
format	article
author	Ilirjana Bajrami Callum Walker Dragomir B. Krastev Daniel Weekes Feifei Song Andrew J. Wicks John Alexander Syed Haider Rachel Brough Stephen J. Pettitt Andrew N. J. Tutt Christopher J. Lord
author_facet	Ilirjana Bajrami Callum Walker Dragomir B. Krastev Daniel Weekes Feifei Song Andrew J. Wicks John Alexander Syed Haider Rachel Brough Stephen J. Pettitt Andrew N. J. Tutt Christopher J. Lord
author_sort	Ilirjana Bajrami
title	Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
title_short	Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
title_full	Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
title_fullStr	Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
title_full_unstemmed	Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency
title_sort	sirtuin inhibition is synthetic lethal with brca1 or brca2 deficiency
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d5f5e8c9681d4c1cb2934f06ed9a1386
work_keys_str_mv	AT ilirjanabajrami sirtuininhibitionissyntheticlethalwithbrca1orbrca2deficiency AT callumwalker sirtuininhibitionissyntheticlethalwithbrca1orbrca2deficiency AT dragomirbkrastev sirtuininhibitionissyntheticlethalwithbrca1orbrca2deficiency AT danielweekes sirtuininhibitionissyntheticlethalwithbrca1orbrca2deficiency AT feifeisong sirtuininhibitionissyntheticlethalwithbrca1orbrca2deficiency AT andrewjwicks sirtuininhibitionissyntheticlethalwithbrca1orbrca2deficiency AT johnalexander sirtuininhibitionissyntheticlethalwithbrca1orbrca2deficiency AT syedhaider sirtuininhibitionissyntheticlethalwithbrca1orbrca2deficiency AT rachelbrough sirtuininhibitionissyntheticlethalwithbrca1orbrca2deficiency AT stephenjpettitt sirtuininhibitionissyntheticlethalwithbrca1orbrca2deficiency AT andrewnjtutt sirtuininhibitionissyntheticlethalwithbrca1orbrca2deficiency AT christopherjlord sirtuininhibitionissyntheticlethalwithbrca1orbrca2deficiency
_version_	1718429375891767296

Sirtuin inhibition is synthetic lethal with BRCA1 or BRCA2 deficiency

Ejemplares similares