PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia

The role of ciliary/centriolar components in the postnatal brain is unclear. Here, the authors show via ablation of Pcm1 in mice that degenerative ciliary/centriolar phenotypes induce neuroanatomical and behavioral changes. Sequencing of PCM1 in human cohorts and zebrafish in vivo complementation su...

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Autores principales:	Tanner O. Monroe, Melanie E. Garrett, Maria Kousi, Ramona M. Rodriguiz, Sungjin Moon, Yushi Bai, Steven C. Brodar, Karen L. Soldano, Jeremiah Savage, Thomas F. Hansen, Donna M. Muzny, Richard A. Gibbs, Lawrence Barak, Patrick F. Sullivan, Allison E. Ashley-Koch, Akira Sawa, William C. Wetsel, Thomas Werge, Nicholas Katsanis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d5f60ef175b64f618a0d4c6e80cba746
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spelling	oai:doaj.org-article:d5f60ef175b64f618a0d4c6e80cba7462021-12-02T15:39:19ZPCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia10.1038/s41467-020-19637-52041-1723https://doaj.org/article/d5f60ef175b64f618a0d4c6e80cba7462020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19637-5https://doaj.org/toc/2041-1723The role of ciliary/centriolar components in the postnatal brain is unclear. Here, the authors show via ablation of Pcm1 in mice that degenerative ciliary/centriolar phenotypes induce neuroanatomical and behavioral changes. Sequencing of PCM1 in human cohorts and zebrafish in vivo complementation suggests PCM1 mutations can contribute to schizophrenia.Tanner O. MonroeMelanie E. GarrettMaria KousiRamona M. RodriguizSungjin MoonYushi BaiSteven C. BrodarKaren L. SoldanoJeremiah SavageThomas F. HansenDonna M. MuznyRichard A. GibbsLawrence BarakPatrick F. SullivanAllison E. Ashley-KochAkira SawaWilliam C. WetselThomas WergeNicholas KatsanisNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tanner O. Monroe Melanie E. Garrett Maria Kousi Ramona M. Rodriguiz Sungjin Moon Yushi Bai Steven C. Brodar Karen L. Soldano Jeremiah Savage Thomas F. Hansen Donna M. Muzny Richard A. Gibbs Lawrence Barak Patrick F. Sullivan Allison E. Ashley-Koch Akira Sawa William C. Wetsel Thomas Werge Nicholas Katsanis PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia
description	The role of ciliary/centriolar components in the postnatal brain is unclear. Here, the authors show via ablation of Pcm1 in mice that degenerative ciliary/centriolar phenotypes induce neuroanatomical and behavioral changes. Sequencing of PCM1 in human cohorts and zebrafish in vivo complementation suggests PCM1 mutations can contribute to schizophrenia.
format	article
author	Tanner O. Monroe Melanie E. Garrett Maria Kousi Ramona M. Rodriguiz Sungjin Moon Yushi Bai Steven C. Brodar Karen L. Soldano Jeremiah Savage Thomas F. Hansen Donna M. Muzny Richard A. Gibbs Lawrence Barak Patrick F. Sullivan Allison E. Ashley-Koch Akira Sawa William C. Wetsel Thomas Werge Nicholas Katsanis
author_facet	Tanner O. Monroe Melanie E. Garrett Maria Kousi Ramona M. Rodriguiz Sungjin Moon Yushi Bai Steven C. Brodar Karen L. Soldano Jeremiah Savage Thomas F. Hansen Donna M. Muzny Richard A. Gibbs Lawrence Barak Patrick F. Sullivan Allison E. Ashley-Koch Akira Sawa William C. Wetsel Thomas Werge Nicholas Katsanis
author_sort	Tanner O. Monroe
title	PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia
title_short	PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia
title_full	PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia
title_fullStr	PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia
title_full_unstemmed	PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia
title_sort	pcm1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/d5f60ef175b64f618a0d4c6e80cba746
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PCM1 is necessary for focal ciliary integrity and is a candidate for severe schizophrenia

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