Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction

Cell behaviors and functions show distinct contrast in different mechanical microenvironment. Numerous materials with varied rigidity have been developed to mimic the interactions between cells and their surroundings. However, the conventional static materials cannot fully capture the dynamic altera...

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Autores principales:	Qian Sun, Yong Hou, Zhiqin Chu, Qiang Wei
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2022
Materias:	Cell Mechanotransduction Intracellular force Biomaterials Soft materials Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d5f8d4c5e7db4fb6928fb7305e9064c3
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spelling	oai:doaj.org-article:d5f8d4c5e7db4fb6928fb7305e9064c32021-11-28T04:35:16ZSoft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction2452-199X10.1016/j.bioactmat.2021.08.026https://doaj.org/article/d5f8d4c5e7db4fb6928fb7305e9064c32022-04-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2452199X21004023https://doaj.org/toc/2452-199XCell behaviors and functions show distinct contrast in different mechanical microenvironment. Numerous materials with varied rigidity have been developed to mimic the interactions between cells and their surroundings. However, the conventional static materials cannot fully capture the dynamic alterations at the bio-interface, especially for the molecular motion and the local mechanical changes in nanoscale. As an alternative, flexible materials have great potential to sense and adapt to mechanical changes in such complex microenvironment. The flexible materials could promote the cellular mechanosensing by dynamically adjusting their local mechanics, topography and ligand presentation to adapt to intracellular force generation. This process enables the cells to exhibit comparable or even higher level of mechanotransduction and the downstream ‘hard’ phenotypes compared to the conventional stiff or rigid ones. Here, we highlight the relevant studies regarding the development of such adaptive materials to mediate cell behaviors across the rigidity limitation on soft substrates. The concept of ‘soft overcomes the hard’ will guide the future development and application of biological materials.Qian SunYong HouZhiqin ChuQiang WeiKeAi Communications Co., Ltd.articleCellMechanotransductionIntracellular forceBiomaterialsSoft materialsMaterials of engineering and construction. Mechanics of materialsTA401-492Biology (General)QH301-705.5ENBioactive Materials, Vol 10, Iss , Pp 397-404 (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cell Mechanotransduction Intracellular force Biomaterials Soft materials Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5
spellingShingle	Cell Mechanotransduction Intracellular force Biomaterials Soft materials Materials of engineering and construction. Mechanics of materials TA401-492 Biology (General) QH301-705.5 Qian Sun Yong Hou Zhiqin Chu Qiang Wei Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction
description	Cell behaviors and functions show distinct contrast in different mechanical microenvironment. Numerous materials with varied rigidity have been developed to mimic the interactions between cells and their surroundings. However, the conventional static materials cannot fully capture the dynamic alterations at the bio-interface, especially for the molecular motion and the local mechanical changes in nanoscale. As an alternative, flexible materials have great potential to sense and adapt to mechanical changes in such complex microenvironment. The flexible materials could promote the cellular mechanosensing by dynamically adjusting their local mechanics, topography and ligand presentation to adapt to intracellular force generation. This process enables the cells to exhibit comparable or even higher level of mechanotransduction and the downstream ‘hard’ phenotypes compared to the conventional stiff or rigid ones. Here, we highlight the relevant studies regarding the development of such adaptive materials to mediate cell behaviors across the rigidity limitation on soft substrates. The concept of ‘soft overcomes the hard’ will guide the future development and application of biological materials.
format	article
author	Qian Sun Yong Hou Zhiqin Chu Qiang Wei
author_facet	Qian Sun Yong Hou Zhiqin Chu Qiang Wei
author_sort	Qian Sun
title	Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction
title_short	Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction
title_full	Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction
title_fullStr	Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction
title_full_unstemmed	Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction
title_sort	soft overcomes the hard: flexible materials adapt to cell adhesion to promote cell mechanotransduction
publisher	KeAi Communications Co., Ltd.
publishDate	2022
url	https://doaj.org/article/d5f8d4c5e7db4fb6928fb7305e9064c3
work_keys_str_mv	AT qiansun softovercomesthehardflexiblematerialsadapttocelladhesiontopromotecellmechanotransduction AT yonghou softovercomesthehardflexiblematerialsadapttocelladhesiontopromotecellmechanotransduction AT zhiqinchu softovercomesthehardflexiblematerialsadapttocelladhesiontopromotecellmechanotransduction AT qiangwei softovercomesthehardflexiblematerialsadapttocelladhesiontopromotecellmechanotransduction
_version_	1718408347559919616

Soft overcomes the hard: Flexible materials adapt to cell adhesion to promote cell mechanotransduction

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