Effects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars

Abstract Mineral trioxide aggregate (MTA) is a commonly used dental pulp-capping material with known effects in promoting reparative dentinogenesis. However, the mechanism by which MTA induces dentine repair remains unclear. The aim of the present study was to investigate the role of prostaglandin E...

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Autores principales:	Naoto Ohkura, Naoki Edanami, Ryosuke Takeuchi, Aiko Tohma, Mariko Ohkura, Nagako Yoshiba, Kunihiko Yoshiba, Hiroko Ida-Yonemochi, Hayato Ohshima, Takashi Okiji, Yuichiro Noiri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d5fc688c851b4bd8a3645ff8e45c0b10
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spelling	oai:doaj.org-article:d5fc688c851b4bd8a3645ff8e45c0b102021-12-02T12:32:15ZEffects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars10.1038/s41598-017-07167-y2045-2322https://doaj.org/article/d5fc688c851b4bd8a3645ff8e45c0b102017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-07167-yhttps://doaj.org/toc/2045-2322Abstract Mineral trioxide aggregate (MTA) is a commonly used dental pulp-capping material with known effects in promoting reparative dentinogenesis. However, the mechanism by which MTA induces dentine repair remains unclear. The aim of the present study was to investigate the role of prostaglandin E2 (PGE2) in dentine repair by examining the localisation and mRNA expression levels of its transporter (Pgt) and two of its receptors (Ep2 and Ep4) in a rat model of pulpotomy with MTA capping. Ep2 expression was detected in odontoblasts, endothelial cells, and nerve fibres in normal and pulpotomised tissues, whereas Pgt and Ep4 were immunolocalised only in the odontoblasts. Moreover, mRNA expression of Slco2a1 (encoding Pgt), Ptger2 (encoding Ep2), and Ptger4 (encoding Ep4) was significantly upregulated in pulpotomised dental pulp and trigeminal ganglia after MTA capping. Our results provide insights into the functions of PGE2 via Pgt and Ep receptors in the healing dentine/pulp complex and may be helpful in developing new therapeutic targets for dental disease.Naoto OhkuraNaoki EdanamiRyosuke TakeuchiAiko TohmaMariko OhkuraNagako YoshibaKunihiko YoshibaHiroko Ida-YonemochiHayato OhshimaTakashi OkijiYuichiro NoiriNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Naoto Ohkura Naoki Edanami Ryosuke Takeuchi Aiko Tohma Mariko Ohkura Nagako Yoshiba Kunihiko Yoshiba Hiroko Ida-Yonemochi Hayato Ohshima Takashi Okiji Yuichiro Noiri Effects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars
description	Abstract Mineral trioxide aggregate (MTA) is a commonly used dental pulp-capping material with known effects in promoting reparative dentinogenesis. However, the mechanism by which MTA induces dentine repair remains unclear. The aim of the present study was to investigate the role of prostaglandin E2 (PGE2) in dentine repair by examining the localisation and mRNA expression levels of its transporter (Pgt) and two of its receptors (Ep2 and Ep4) in a rat model of pulpotomy with MTA capping. Ep2 expression was detected in odontoblasts, endothelial cells, and nerve fibres in normal and pulpotomised tissues, whereas Pgt and Ep4 were immunolocalised only in the odontoblasts. Moreover, mRNA expression of Slco2a1 (encoding Pgt), Ptger2 (encoding Ep2), and Ptger4 (encoding Ep4) was significantly upregulated in pulpotomised dental pulp and trigeminal ganglia after MTA capping. Our results provide insights into the functions of PGE2 via Pgt and Ep receptors in the healing dentine/pulp complex and may be helpful in developing new therapeutic targets for dental disease.
format	article
author	Naoto Ohkura Naoki Edanami Ryosuke Takeuchi Aiko Tohma Mariko Ohkura Nagako Yoshiba Kunihiko Yoshiba Hiroko Ida-Yonemochi Hayato Ohshima Takashi Okiji Yuichiro Noiri
author_facet	Naoto Ohkura Naoki Edanami Ryosuke Takeuchi Aiko Tohma Mariko Ohkura Nagako Yoshiba Kunihiko Yoshiba Hiroko Ida-Yonemochi Hayato Ohshima Takashi Okiji Yuichiro Noiri
author_sort	Naoto Ohkura
title	Effects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars
title_short	Effects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars
title_full	Effects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars
title_fullStr	Effects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars
title_full_unstemmed	Effects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars
title_sort	effects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d5fc688c851b4bd8a3645ff8e45c0b10
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Effects of pulpotomy using mineral trioxide aggregate on prostaglandin transporter and receptors in rat molars

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