CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity

CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity

CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tumor suppressor gene silencing.

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Autores principales: Sergey Karakashev, Hengrui Zhu, Shuai Wu, Yuhki Yokoyama, Benjamin G. Bitler, Pyoung-Hwa Park, Jeong-Heon Lee, Andrew V. Kossenkov, Krutika Satish Gaonkar, Huihuang Yan, Ronny Drapkin, Jose R. Conejo-Garcia, David W. Speicher, Tamas Ordog, Rugang Zhang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/d5feab71b5d34b35b80ea5240b6980bc
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spelling oai:doaj.org-article:d5feab71b5d34b35b80ea5240b6980bc2021-12-02T17:31:42ZCARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity10.1038/s41467-018-03031-32041-1723https://doaj.org/article/d5feab71b5d34b35b80ea5240b6980bc2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03031-3https://doaj.org/toc/2041-1723CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tumor suppressor gene silencing.Sergey KarakashevHengrui ZhuShuai WuYuhki YokoyamaBenjamin G. BitlerPyoung-Hwa ParkJeong-Heon LeeAndrew V. KossenkovKrutika Satish GaonkarHuihuang YanRonny DrapkinJose R. Conejo-GarciaDavid W. SpeicherTamas OrdogRugang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sergey Karakashev
Hengrui Zhu
Shuai Wu
Yuhki Yokoyama
Benjamin G. Bitler
Pyoung-Hwa Park
Jeong-Heon Lee
Andrew V. Kossenkov
Krutika Satish Gaonkar
Huihuang Yan
Ronny Drapkin
Jose R. Conejo-Garcia
David W. Speicher
Tamas Ordog
Rugang Zhang
CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
description CARM1 is an arginine methyltransferase often overexpressed in human cancer. Here, the authors show that EZH2 inhibition suppresses growth in CARM1-expressing epithelial ovarian cancer, and examine the mechanism of how CARM1 promotes EZH2-mediated tumor suppressor gene silencing.
format article
author Sergey Karakashev
Hengrui Zhu
Shuai Wu
Yuhki Yokoyama
Benjamin G. Bitler
Pyoung-Hwa Park
Jeong-Heon Lee
Andrew V. Kossenkov
Krutika Satish Gaonkar
Huihuang Yan
Ronny Drapkin
Jose R. Conejo-Garcia
David W. Speicher
Tamas Ordog
Rugang Zhang
author_facet Sergey Karakashev
Hengrui Zhu
Shuai Wu
Yuhki Yokoyama
Benjamin G. Bitler
Pyoung-Hwa Park
Jeong-Heon Lee
Andrew V. Kossenkov
Krutika Satish Gaonkar
Huihuang Yan
Ronny Drapkin
Jose R. Conejo-Garcia
David W. Speicher
Tamas Ordog
Rugang Zhang
author_sort Sergey Karakashev
title CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
title_short CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
title_full CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
title_fullStr CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
title_full_unstemmed CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
title_sort carm1-expressing ovarian cancer depends on the histone methyltransferase ezh2 activity
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/d5feab71b5d34b35b80ea5240b6980bc
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