Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment

Introduction: Wildfire smoke (WFS) exposure is a growing threat to human health, and lower socioeconomic position (SEP) has been shown to increase pollution susceptibility. Studies of SEP-related susceptibility, however, are often compromised due to spatial confounding between lower-SEP and pollutio...

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Autores principales:	Heng Bai, John P. Capitanio, Lisa A. Miller, Jane E. Clougherty
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Wildfire smoke Infancy exposure Socioeconomic status Lung volume Cytokine response Science (General) Q1-390 Social sciences (General) H1-99
Acceso en línea:	https://doaj.org/article/d600005f4b6b4191835204c6b96a4afb
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spelling	oai:doaj.org-article:d600005f4b6b4191835204c6b96a4afb2021-12-02T05:02:41ZSocial status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment2405-844010.1016/j.heliyon.2021.e08333https://doaj.org/article/d600005f4b6b4191835204c6b96a4afb2021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2405844021024361https://doaj.org/toc/2405-8440Introduction: Wildfire smoke (WFS) exposure is a growing threat to human health, and lower socioeconomic position (SEP) has been shown to increase pollution susceptibility. Studies of SEP-related susceptibility, however, are often compromised due to spatial confounding between lower-SEP and pollution. Here we examine outdoor-housed nonhuman primates, living in natural social hierarchy in a common location, born during years of high vs. low WFS, to examine the separate and combined effects of WFS and social rank, an analog to SEP, on lung and immune function. Methods: Twenty-one females were born during extreme WFS events in summer 2008; 22 were born in summer 2009, during low WFS. Pulmonary function and circulating cytokines were measured three years later, in adolescence. We estimated fine particulate (PM2.5) and ozone exposures during each animal's first 90 days and three years of age using regulatory data. Early-life social status was estimated using maternal rank at birth, as rank in females is relatively stable throughout life, and closely approximates mother's rank. We tested associations among WFS exposure, rank, and endpoints using linear regression and ANOVA. Results: Higher WFS exposure in infancy was, on average, associated with lower functional residual capacity (FRC), residual volume (RV), tissue compliance (Ct), and IL-8 secretion in adolescence. Higher social rank conferred significantly higher expiratory reserve volume (ERV) and functional residual capacity (FRC) solely among those born in the high-WFS year (2008). Differences in effects of rank between years were not significant after adjustment for multiple comparisons. Conclusions: Exposure to WFS in infancy generally conferred lower adolescent respiratory volumes and inflammatory cytokines. Higher rank conferred higher respiratory volumes only among females born during WFS, suggesting the possibility that the health benefits of rank may be more apparent under environmental challenge.Heng BaiJohn P. CapitanioLisa A. MillerJane E. CloughertyElsevierarticleWildfire smokeInfancy exposureSocioeconomic statusLung volumeCytokine responseScience (General)Q1-390Social sciences (General)H1-99ENHeliyon, Vol 7, Iss 11, Pp e08333- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Wildfire smoke Infancy exposure Socioeconomic status Lung volume Cytokine response Science (General) Q1-390 Social sciences (General) H1-99
spellingShingle	Wildfire smoke Infancy exposure Socioeconomic status Lung volume Cytokine response Science (General) Q1-390 Social sciences (General) H1-99 Heng Bai John P. Capitanio Lisa A. Miller Jane E. Clougherty Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment
description	Introduction: Wildfire smoke (WFS) exposure is a growing threat to human health, and lower socioeconomic position (SEP) has been shown to increase pollution susceptibility. Studies of SEP-related susceptibility, however, are often compromised due to spatial confounding between lower-SEP and pollution. Here we examine outdoor-housed nonhuman primates, living in natural social hierarchy in a common location, born during years of high vs. low WFS, to examine the separate and combined effects of WFS and social rank, an analog to SEP, on lung and immune function. Methods: Twenty-one females were born during extreme WFS events in summer 2008; 22 were born in summer 2009, during low WFS. Pulmonary function and circulating cytokines were measured three years later, in adolescence. We estimated fine particulate (PM2.5) and ozone exposures during each animal's first 90 days and three years of age using regulatory data. Early-life social status was estimated using maternal rank at birth, as rank in females is relatively stable throughout life, and closely approximates mother's rank. We tested associations among WFS exposure, rank, and endpoints using linear regression and ANOVA. Results: Higher WFS exposure in infancy was, on average, associated with lower functional residual capacity (FRC), residual volume (RV), tissue compliance (Ct), and IL-8 secretion in adolescence. Higher social rank conferred significantly higher expiratory reserve volume (ERV) and functional residual capacity (FRC) solely among those born in the high-WFS year (2008). Differences in effects of rank between years were not significant after adjustment for multiple comparisons. Conclusions: Exposure to WFS in infancy generally conferred lower adolescent respiratory volumes and inflammatory cytokines. Higher rank conferred higher respiratory volumes only among females born during WFS, suggesting the possibility that the health benefits of rank may be more apparent under environmental challenge.
format	article
author	Heng Bai John P. Capitanio Lisa A. Miller Jane E. Clougherty
author_facet	Heng Bai John P. Capitanio Lisa A. Miller Jane E. Clougherty
author_sort	Heng Bai
title	Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment
title_short	Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment
title_full	Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment
title_fullStr	Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment
title_full_unstemmed	Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment
title_sort	social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: a natural experiment
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/d600005f4b6b4191835204c6b96a4afb
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Social status and susceptibility to wildfire smoke among outdoor-housed female rhesus monkeys: A natural experiment

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