Altered blood oxygen level-dependent signal variability in chronic post-traumatic stress disorder during symptom provocation

Jun Ke,1,* Li Zhang,2,* Rongfeng Qi,1,* Qiang Xu,1 Weihui Li,2 Cailan Hou,3 Yuan Zhong,1 Zhiqiang Zhang,1 Zhong He,4 Lingjiang Li,2,5 Guangming Lu11Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, 2Mental Health Institute, the Second Xiangya Hospital, N...

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Autores principales:	Ke J, Zhang L, Qi R, Xu Q, Li W, Hou C, Zhong Y, Zhang Z, He Z, Li L, Lu G
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/d6053b18514745cfb81672c9628d91f6
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spelling	oai:doaj.org-article:d6053b18514745cfb81672c9628d91f62021-12-02T01:31:36ZAltered blood oxygen level-dependent signal variability in chronic post-traumatic stress disorder during symptom provocation1178-2021https://doaj.org/article/d6053b18514745cfb81672c9628d91f62015-07-01T00:00:00Zhttp://www.dovepress.com/altered-blood-oxygen-level-dependent-signal-variability-in-chronic-pos-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jun Ke,1,* Li Zhang,2,* Rongfeng Qi,1,* Qiang Xu,1 Weihui Li,2 Cailan Hou,3 Yuan Zhong,1 Zhiqiang Zhang,1 Zhong He,4 Lingjiang Li,2,5 Guangming Lu11Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, 2Mental Health Institute, the Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, 3Guangdong Academy of Medical Science, Guangdong General Hospital, Guangdong Mental Health Center, Guangzhou, 4Department of Radiology of the Second Xiangya Hospital, Central South University, Changsha, 5Shenzhen Kangning Hospital of Guangdong Province, Shenzhen, People’s Republic of China*These authors contributed equally to this workBackground: Recent research suggests that variability in brain signal provides important information about brain function in health and disease. However, it is unknown whether blood oxygen level-dependent (BOLD) signal variability is altered in post-traumatic stress disorder (PTSD). We aimed to identify the BOLD signal variability changes of PTSD patients during symptom provocation and compare the brain patterns of BOLD signal variability with those of brain activation.Methods: Twelve PTSD patients and 14 age-matched controls, who all experienced a mining accident, underwent clinical assessment as well as fMRI scanning while viewing trauma-related and neutral pictures. BOLD signal variability and brain activation were respectively examined with standard deviation (SD) and general linear model analysis, and compared between the PTSD and control groups. Multiple regression analyses were conducted to explore the association between PTSD symptom severity and these two brain measures across all subjects as well as in the PTSD group.Results: PTSD patients showed increased activation in the middle occipital gyrus compared with controls, and an inverse correlation was found between PTSD symptom severity and brain activation in the hippocampus and anterior cingulate cortex/medial prefrontal cortex. Brain variability analysis revealed increased SD in the insula, anterior cingulate cortex/medial prefrontal cortex, and vermis, and decreased SD in the parahippocapal gyrus, dorsolateral prefrontal cortex, somatosensory cortex, and striatum. Importantly, SD alterations in several regions were found in both traumatic and neutral conditions and were stratified by PTSD symptom severity.Conclusion: BOLD signal variability may be a reliable and sensitive biomarker of PTSD, and combining brain activation and brain variability analysis may provide complementary insight into the neural basis of this disorder.Keywords: brain variability, general linear model, insula, functional magnetic resonance imagingKe JZhang LQi RXu QLi WHou CZhong YZhang ZHe ZLi LLu GDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 1805-1815 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ke J Zhang L Qi R Xu Q Li W Hou C Zhong Y Zhang Z He Z Li L Lu G Altered blood oxygen level-dependent signal variability in chronic post-traumatic stress disorder during symptom provocation
description	Jun Ke,1,* Li Zhang,2,* Rongfeng Qi,1,* Qiang Xu,1 Weihui Li,2 Cailan Hou,3 Yuan Zhong,1 Zhiqiang Zhang,1 Zhong He,4 Lingjiang Li,2,5 Guangming Lu11Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, Nanjing, 2Mental Health Institute, the Second Xiangya Hospital, National Technology Institute of Psychiatry, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, 3Guangdong Academy of Medical Science, Guangdong General Hospital, Guangdong Mental Health Center, Guangzhou, 4Department of Radiology of the Second Xiangya Hospital, Central South University, Changsha, 5Shenzhen Kangning Hospital of Guangdong Province, Shenzhen, People’s Republic of China*These authors contributed equally to this workBackground: Recent research suggests that variability in brain signal provides important information about brain function in health and disease. However, it is unknown whether blood oxygen level-dependent (BOLD) signal variability is altered in post-traumatic stress disorder (PTSD). We aimed to identify the BOLD signal variability changes of PTSD patients during symptom provocation and compare the brain patterns of BOLD signal variability with those of brain activation.Methods: Twelve PTSD patients and 14 age-matched controls, who all experienced a mining accident, underwent clinical assessment as well as fMRI scanning while viewing trauma-related and neutral pictures. BOLD signal variability and brain activation were respectively examined with standard deviation (SD) and general linear model analysis, and compared between the PTSD and control groups. Multiple regression analyses were conducted to explore the association between PTSD symptom severity and these two brain measures across all subjects as well as in the PTSD group.Results: PTSD patients showed increased activation in the middle occipital gyrus compared with controls, and an inverse correlation was found between PTSD symptom severity and brain activation in the hippocampus and anterior cingulate cortex/medial prefrontal cortex. Brain variability analysis revealed increased SD in the insula, anterior cingulate cortex/medial prefrontal cortex, and vermis, and decreased SD in the parahippocapal gyrus, dorsolateral prefrontal cortex, somatosensory cortex, and striatum. Importantly, SD alterations in several regions were found in both traumatic and neutral conditions and were stratified by PTSD symptom severity.Conclusion: BOLD signal variability may be a reliable and sensitive biomarker of PTSD, and combining brain activation and brain variability analysis may provide complementary insight into the neural basis of this disorder.Keywords: brain variability, general linear model, insula, functional magnetic resonance imaging
format	article
author	Ke J Zhang L Qi R Xu Q Li W Hou C Zhong Y Zhang Z He Z Li L Lu G
author_facet	Ke J Zhang L Qi R Xu Q Li W Hou C Zhong Y Zhang Z He Z Li L Lu G
author_sort	Ke J
title	Altered blood oxygen level-dependent signal variability in chronic post-traumatic stress disorder during symptom provocation
title_short	Altered blood oxygen level-dependent signal variability in chronic post-traumatic stress disorder during symptom provocation
title_full	Altered blood oxygen level-dependent signal variability in chronic post-traumatic stress disorder during symptom provocation
title_fullStr	Altered blood oxygen level-dependent signal variability in chronic post-traumatic stress disorder during symptom provocation
title_full_unstemmed	Altered blood oxygen level-dependent signal variability in chronic post-traumatic stress disorder during symptom provocation
title_sort	altered blood oxygen level-dependent signal variability in chronic post-traumatic stress disorder during symptom provocation
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/d6053b18514745cfb81672c9628d91f6
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Altered blood oxygen level-dependent signal variability in chronic post-traumatic stress disorder during symptom provocation

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