NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation

IL-15 orchestrates NK cell metabolism, proliferation, and activation. Here the authors show that Tsc1 is dispensable for mature NK cells but is critical for survival of immature NK by preventing their exhaustive proliferation and activation downstream of IL-15.

Guardado en:

Detalles Bibliográficos
Autores principales:	Meixiang Yang, Shasha Chen, Juan Du, Junming He, Yuande Wang, Zehua Li, Guangao Liu, Wanwen Peng, Xiaokang Zeng, Dan Li, Panglian Xu, Wei Guo, Zai Chang, Song Wang, Zhigang Tian, Zhongjun Dong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d609b2fc4fae4303b7be1b99f603f8c6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:d609b2fc4fae4303b7be1b99f603f8c6
record_format	dspace
spelling	oai:doaj.org-article:d609b2fc4fae4303b7be1b99f603f8c62021-12-02T14:40:15ZNK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation10.1038/ncomms127302041-1723https://doaj.org/article/d609b2fc4fae4303b7be1b99f603f8c62016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12730https://doaj.org/toc/2041-1723IL-15 orchestrates NK cell metabolism, proliferation, and activation. Here the authors show that Tsc1 is dispensable for mature NK cells but is critical for survival of immature NK by preventing their exhaustive proliferation and activation downstream of IL-15.Meixiang YangShasha ChenJuan DuJunming HeYuande WangZehua LiGuangao LiuWanwen PengXiaokang ZengDan LiPanglian XuWei GuoZai ChangSong WangZhigang TianZhongjun DongNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Meixiang Yang Shasha Chen Juan Du Junming He Yuande Wang Zehua Li Guangao Liu Wanwen Peng Xiaokang Zeng Dan Li Panglian Xu Wei Guo Zai Chang Song Wang Zhigang Tian Zhongjun Dong NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation
description	IL-15 orchestrates NK cell metabolism, proliferation, and activation. Here the authors show that Tsc1 is dispensable for mature NK cells but is critical for survival of immature NK by preventing their exhaustive proliferation and activation downstream of IL-15.
format	article
author	Meixiang Yang Shasha Chen Juan Du Junming He Yuande Wang Zehua Li Guangao Liu Wanwen Peng Xiaokang Zeng Dan Li Panglian Xu Wei Guo Zai Chang Song Wang Zhigang Tian Zhongjun Dong
author_facet	Meixiang Yang Shasha Chen Juan Du Junming He Yuande Wang Zehua Li Guangao Liu Wanwen Peng Xiaokang Zeng Dan Li Panglian Xu Wei Guo Zai Chang Song Wang Zhigang Tian Zhongjun Dong
author_sort	Meixiang Yang
title	NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation
title_short	NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation
title_full	NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation
title_fullStr	NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation
title_full_unstemmed	NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation
title_sort	nk cell development requires tsc1-dependent negative regulation of il-15-triggered mtorc1 activation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/d609b2fc4fae4303b7be1b99f603f8c6
work_keys_str_mv	AT meixiangyang nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT shashachen nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT juandu nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT junminghe nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT yuandewang nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT zehuali nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT guangaoliu nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT wanwenpeng nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT xiaokangzeng nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT danli nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT panglianxu nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT weiguo nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT zaichang nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT songwang nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT zhigangtian nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation AT zhongjundong nkcelldevelopmentrequirestsc1dependentnegativeregulationofil15triggeredmtorc1activation
_version_	1718390388602961920

NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation

Ejemplares similares