NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation

NK cell development requires Tsc1-dependent negative regulation of IL-15-triggered mTORC1 activation

IL-15 orchestrates NK cell metabolism, proliferation, and activation. Here the authors show that Tsc1 is dispensable for mature NK cells but is critical for survival of immature NK by preventing their exhaustive proliferation and activation downstream of IL-15.

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Detalles Bibliográficos
Autores principales: Meixiang Yang, Shasha Chen, Juan Du, Junming He, Yuande Wang, Zehua Li, Guangao Liu, Wanwen Peng, Xiaokang Zeng, Dan Li, Panglian Xu, Wei Guo, Zai Chang, Song Wang, Zhigang Tian, Zhongjun Dong
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
Materias:
Science
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Acceso en línea:https://doaj.org/article/d609b2fc4fae4303b7be1b99f603f8c6
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