Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma

Relapse following BCMA targeted CAR T-cell therapy is frequently observed in patients with multiple myeloma (MM). Here, by single cell transcriptome profiling on serially collected bone marrow samples, the authors report biallelic loss of BCMA as the mechanism of resistance underlying both relapse a...

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Autores principales:	Mehmet Kemal Samur, Mariateresa Fulciniti, Anil Aktas Samur, Abdul Hamid Bazarbachi, Yu-Tzu Tai, Rao Prabhala, Alejandro Alonso, Adam S. Sperling, Timothy Campbell, Fabio Petrocca, Kristen Hege, Shari Kaiser, Hervé Avet Loiseau, Kenneth C. Anderson, Nikhil C. Munshi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d60d813fb4064441b48a7626818c3ce7
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spelling	oai:doaj.org-article:d60d813fb4064441b48a7626818c3ce72021-12-02T14:26:51ZBiallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma10.1038/s41467-021-21177-52041-1723https://doaj.org/article/d60d813fb4064441b48a7626818c3ce72021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21177-5https://doaj.org/toc/2041-1723Relapse following BCMA targeted CAR T-cell therapy is frequently observed in patients with multiple myeloma (MM). Here, by single cell transcriptome profiling on serially collected bone marrow samples, the authors report biallelic loss of BCMA as the mechanism of resistance underlying both relapse and lack of response to a second CAR T infusion in a patient with MM.Mehmet Kemal SamurMariateresa FulcinitiAnil Aktas SamurAbdul Hamid BazarbachiYu-Tzu TaiRao PrabhalaAlejandro AlonsoAdam S. SperlingTimothy CampbellFabio PetroccaKristen HegeShari KaiserHervé Avet LoiseauKenneth C. AndersonNikhil C. MunshiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mehmet Kemal Samur Mariateresa Fulciniti Anil Aktas Samur Abdul Hamid Bazarbachi Yu-Tzu Tai Rao Prabhala Alejandro Alonso Adam S. Sperling Timothy Campbell Fabio Petrocca Kristen Hege Shari Kaiser Hervé Avet Loiseau Kenneth C. Anderson Nikhil C. Munshi Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma
description	Relapse following BCMA targeted CAR T-cell therapy is frequently observed in patients with multiple myeloma (MM). Here, by single cell transcriptome profiling on serially collected bone marrow samples, the authors report biallelic loss of BCMA as the mechanism of resistance underlying both relapse and lack of response to a second CAR T infusion in a patient with MM.
format	article
author	Mehmet Kemal Samur Mariateresa Fulciniti Anil Aktas Samur Abdul Hamid Bazarbachi Yu-Tzu Tai Rao Prabhala Alejandro Alonso Adam S. Sperling Timothy Campbell Fabio Petrocca Kristen Hege Shari Kaiser Hervé Avet Loiseau Kenneth C. Anderson Nikhil C. Munshi
author_facet	Mehmet Kemal Samur Mariateresa Fulciniti Anil Aktas Samur Abdul Hamid Bazarbachi Yu-Tzu Tai Rao Prabhala Alejandro Alonso Adam S. Sperling Timothy Campbell Fabio Petrocca Kristen Hege Shari Kaiser Hervé Avet Loiseau Kenneth C. Anderson Nikhil C. Munshi
author_sort	Mehmet Kemal Samur
title	Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma
title_short	Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma
title_full	Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma
title_fullStr	Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma
title_full_unstemmed	Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma
title_sort	biallelic loss of bcma as a resistance mechanism to car t cell therapy in a patient with multiple myeloma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d60d813fb4064441b48a7626818c3ce7
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Biallelic loss of BCMA as a resistance mechanism to CAR T cell therapy in a patient with multiple myeloma

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