A structured RNA motif locks Argonaute2:miR-122 onto the 5’ end of the HCV genome

The RNA genome of the Hepatitis C Virus binds to the liver-specific miR122. Here the authors report the crystal structure of the Ago2:miR122:HCV complex showing that the viral RNA’s structural element traps the Ago2:miR-122 complex on the 5’ end of the viral genome to protect it from degradation....

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Autores principales:	Luca F. R. Gebert, Mansun Law, Ian J. MacRae
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d60f20e8b78f473e98b7f4aa71a57e00
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id	oai:doaj.org-article:d60f20e8b78f473e98b7f4aa71a57e00
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spelling	oai:doaj.org-article:d60f20e8b78f473e98b7f4aa71a57e002021-11-28T12:34:54ZA structured RNA motif locks Argonaute2:miR-122 onto the 5’ end of the HCV genome10.1038/s41467-021-27177-92041-1723https://doaj.org/article/d60f20e8b78f473e98b7f4aa71a57e002021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27177-9https://doaj.org/toc/2041-1723The RNA genome of the Hepatitis C Virus binds to the liver-specific miR122. Here the authors report the crystal structure of the Ago2:miR122:HCV complex showing that the viral RNA’s structural element traps the Ago2:miR-122 complex on the 5’ end of the viral genome to protect it from degradation.Luca F. R. GebertMansun LawIan J. MacRaeNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luca F. R. Gebert Mansun Law Ian J. MacRae A structured RNA motif locks Argonaute2:miR-122 onto the 5’ end of the HCV genome
description	The RNA genome of the Hepatitis C Virus binds to the liver-specific miR122. Here the authors report the crystal structure of the Ago2:miR122:HCV complex showing that the viral RNA’s structural element traps the Ago2:miR-122 complex on the 5’ end of the viral genome to protect it from degradation.
format	article
author	Luca F. R. Gebert Mansun Law Ian J. MacRae
author_facet	Luca F. R. Gebert Mansun Law Ian J. MacRae
author_sort	Luca F. R. Gebert
title	A structured RNA motif locks Argonaute2:miR-122 onto the 5’ end of the HCV genome
title_short	A structured RNA motif locks Argonaute2:miR-122 onto the 5’ end of the HCV genome
title_full	A structured RNA motif locks Argonaute2:miR-122 onto the 5’ end of the HCV genome
title_fullStr	A structured RNA motif locks Argonaute2:miR-122 onto the 5’ end of the HCV genome
title_full_unstemmed	A structured RNA motif locks Argonaute2:miR-122 onto the 5’ end of the HCV genome
title_sort	structured rna motif locks argonaute2:mir-122 onto the 5’ end of the hcv genome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d60f20e8b78f473e98b7f4aa71a57e00
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A structured RNA motif locks Argonaute2:miR-122 onto the 5’ end of the HCV genome

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