A structured RNA motif locks Argonaute2:miR-122 onto the 5’ end of the HCV genome
The RNA genome of the Hepatitis C Virus binds to the liver-specific miR122. Here the authors report the crystal structure of the Ago2:miR122:HCV complex showing that the viral RNA’s structural element traps the Ago2:miR-122 complex on the 5’ end of the viral genome to protect it from degradation....
Guardado en:
Autores principales: | Luca F. R. Gebert, Mansun Law, Ian J. MacRae |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/d60f20e8b78f473e98b7f4aa71a57e00 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
Exosomes from hepatitis C infected patients transmit HCV infection and contain replication competent viral RNA in complex with Ago2-miR122-HSP90.
por: Terence N Bukong, et al.
Publicado: (2014) -
Viral Determinants of miR-122-Independent Hepatitis C Virus Replication
por: Sharon E. Hopcraft, et al.
Publicado: (2016) -
Chronic administration of proanthocyanidins or docosahexaenoic acid reverses the increase of miR-33a and miR-122 in dyslipidemic obese rats.
por: Laura Baselga-Escudero, et al.
Publicado: (2013) -
The evolution of animal Argonautes: evidence for the absence of antiviral AGO Argonautes in vertebrates
por: Niels Wynant, et al.
Publicado: (2017) -
Serum exosomal miR-122-5p, GAS, and PGR in the non-invasive diagnosis of CAG
por: Liu Naihua, et al.
Publicado: (2021)