Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes

Jonathan Richard White,1 Jody Anne Winter,2 Karen Robinson1 1NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and The University of Nottingham, Nottingham, 2Interdisciplinary Biomedical Research Centre, School of Science and Technology...

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Autores principales:	White JR, Winter JA, Robinson K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/d60fac5685424468b0fe8eb5c13d172f
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spelling	oai:doaj.org-article:d60fac5685424468b0fe8eb5c13d172f2021-12-02T03:53:26ZDifferential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes1178-7031https://doaj.org/article/d60fac5685424468b0fe8eb5c13d172f2015-08-01T00:00:00Zhttp://www.dovepress.com/differential-inflammatory-response-to-helicobacter-pylori-infection-et-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Jonathan Richard White,1 Jody Anne Winter,2 Karen Robinson1 1NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and The University of Nottingham, Nottingham, 2Interdisciplinary Biomedical Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK Abstract: The bacterial pathogen Helicobacter pylori commonly colonizes the human gastric mucosa during early childhood and persists throughout life. The organism has evolved multiple mechanisms for evading clearance by the immune system and, despite inducing inflammation in the stomach, the majority of infections are asymptomatic. H. pylori is the leading cause of peptic ulcer disease and gastric cancer. However, disease outcomes are related to the pattern and severity of chronic inflammation in the gastric mucosa, which in turn is influenced by both bacterial and host factors. Despite over 2 decades of intensive research, there remains an incomplete understanding of the circumstances leading to disease development, due to the fascinating complexity of the host–pathogen interactions. There is accumulating data concerning the virulence factors associated with increased risk of disease, and the majority of these have pro-inflammatory activities. Despite this, only a small proportion of those infected with virulent strains develop disease. Several H. pylori virulence factors have multiple effects on different cell types, including the induction of pro- and anti-inflammatory, immune stimulatory, and immune modulatory responses. The expression of multiple virulence factors is also often linked, making it difficult to assess the meaning of their effects in isolation. Overall, H. pylori is thought to usually modulate inflammation and limit acute damage to the mucosa, enabling the bacteria to persist. If this delicate balance is disturbed, disease may then develop. Keywords: Helicobacter pylori, inflammation, mucosal immunity, peptic ulcer disease, gastric cancerWhite JRWinter JARobinson KDove Medical PressarticlePathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol 2015, Iss default, Pp 137-147 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pathology RB1-214 Therapeutics. Pharmacology RM1-950 White JR Winter JA Robinson K Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes
description	Jonathan Richard White,1 Jody Anne Winter,2 Karen Robinson1 1NIHR Biomedical Research Unit in Gastrointestinal and Liver Diseases at Nottingham University Hospitals NHS Trust and The University of Nottingham, Nottingham, 2Interdisciplinary Biomedical Research Centre, School of Science and Technology, Nottingham Trent University, Nottingham, UK Abstract: The bacterial pathogen Helicobacter pylori commonly colonizes the human gastric mucosa during early childhood and persists throughout life. The organism has evolved multiple mechanisms for evading clearance by the immune system and, despite inducing inflammation in the stomach, the majority of infections are asymptomatic. H. pylori is the leading cause of peptic ulcer disease and gastric cancer. However, disease outcomes are related to the pattern and severity of chronic inflammation in the gastric mucosa, which in turn is influenced by both bacterial and host factors. Despite over 2 decades of intensive research, there remains an incomplete understanding of the circumstances leading to disease development, due to the fascinating complexity of the host–pathogen interactions. There is accumulating data concerning the virulence factors associated with increased risk of disease, and the majority of these have pro-inflammatory activities. Despite this, only a small proportion of those infected with virulent strains develop disease. Several H. pylori virulence factors have multiple effects on different cell types, including the induction of pro- and anti-inflammatory, immune stimulatory, and immune modulatory responses. The expression of multiple virulence factors is also often linked, making it difficult to assess the meaning of their effects in isolation. Overall, H. pylori is thought to usually modulate inflammation and limit acute damage to the mucosa, enabling the bacteria to persist. If this delicate balance is disturbed, disease may then develop. Keywords: Helicobacter pylori, inflammation, mucosal immunity, peptic ulcer disease, gastric cancer
format	article
author	White JR Winter JA Robinson K
author_facet	White JR Winter JA Robinson K
author_sort	White JR
title	Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes
title_short	Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes
title_full	Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes
title_fullStr	Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes
title_full_unstemmed	Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes
title_sort	differential inflammatory response to helicobacter pylori infection: etiology and clinical outcomes
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/d60fac5685424468b0fe8eb5c13d172f
work_keys_str_mv	AT whitejr differentialinflammatoryresponsetohelicobacterpyloriinfectionetiologyandclinicaloutcomes AT winterja differentialinflammatoryresponsetohelicobacterpyloriinfectionetiologyandclinicaloutcomes AT robinsonk differentialinflammatoryresponsetohelicobacterpyloriinfectionetiologyandclinicaloutcomes
_version_	1718401582626766848

Differential inflammatory response to Helicobacter pylori infection: etiology and clinical outcomes

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