Sharing an environment with sick conspecifics alters odors of healthy animals

Abstract Body odors change with health status and the odors of sick animals can induce avoidance behaviors in healthy conspecifics. Exposure to sickness odors might also alter the physiology of healthy conspecifics and modify the odors they produce. We hypothesized that exposure to odors of sick (bu...

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Autores principales:	Stephanie S. Gervasi, Maryanne Opiekun, Talia Martin, Gary K. Beauchamp, Bruce A. Kimball
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Healthy Conspecifics Urinary Volatiles Sick Mice Urine Donors Generalization Trials Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d615abe8a0bb4914aaec4b8a40279539
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spelling	oai:doaj.org-article:d615abe8a0bb4914aaec4b8a402795392021-12-02T15:07:49ZSharing an environment with sick conspecifics alters odors of healthy animals10.1038/s41598-018-32619-42045-2322https://doaj.org/article/d615abe8a0bb4914aaec4b8a402795392018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32619-4https://doaj.org/toc/2045-2322Abstract Body odors change with health status and the odors of sick animals can induce avoidance behaviors in healthy conspecifics. Exposure to sickness odors might also alter the physiology of healthy conspecifics and modify the odors they produce. We hypothesized that exposure to odors of sick (but non-infectious) animals would alter the odors of healthy cagemates. To induce sickness, we injected mice with a bacterial endotoxin, lipopolysaccharide. We used behavioral odor discrimination assays and analytical chemistry techniques followed by predictive classification modeling to ask about differences in volatile odorants produced by two types of healthy mice: those cohoused with healthy conspecifics and those cohoused with sick conspecifics. Mice trained in Y-maze behavioral assays to discriminate between the odors of healthy versus sick mice also discriminated between the odors of healthy mice cohoused with sick conspecifics and odors of healthy mice cohoused with healthy conspecifics. Chemical analyses paired with statistical modeling revealed a parallel phenomenon. Urine volatiles of healthy mice cohoused with sick partners were more likely to be classified as those of sick rather than healthy mice based on discriminant model predictions. Sickness-related odors could have cascading effects on neuroendocrine or immune responses of healthy conspecifics, and could affect individual behaviors, social dynamics, and pathogen spread.Stephanie S. GervasiMaryanne OpiekunTalia MartinGary K. BeauchampBruce A. KimballNature PortfolioarticleHealthy ConspecificsUrinary VolatilesSick MiceUrine DonorsGeneralization TrialsMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Healthy Conspecifics Urinary Volatiles Sick Mice Urine Donors Generalization Trials Medicine R Science Q
spellingShingle	Healthy Conspecifics Urinary Volatiles Sick Mice Urine Donors Generalization Trials Medicine R Science Q Stephanie S. Gervasi Maryanne Opiekun Talia Martin Gary K. Beauchamp Bruce A. Kimball Sharing an environment with sick conspecifics alters odors of healthy animals
description	Abstract Body odors change with health status and the odors of sick animals can induce avoidance behaviors in healthy conspecifics. Exposure to sickness odors might also alter the physiology of healthy conspecifics and modify the odors they produce. We hypothesized that exposure to odors of sick (but non-infectious) animals would alter the odors of healthy cagemates. To induce sickness, we injected mice with a bacterial endotoxin, lipopolysaccharide. We used behavioral odor discrimination assays and analytical chemistry techniques followed by predictive classification modeling to ask about differences in volatile odorants produced by two types of healthy mice: those cohoused with healthy conspecifics and those cohoused with sick conspecifics. Mice trained in Y-maze behavioral assays to discriminate between the odors of healthy versus sick mice also discriminated between the odors of healthy mice cohoused with sick conspecifics and odors of healthy mice cohoused with healthy conspecifics. Chemical analyses paired with statistical modeling revealed a parallel phenomenon. Urine volatiles of healthy mice cohoused with sick partners were more likely to be classified as those of sick rather than healthy mice based on discriminant model predictions. Sickness-related odors could have cascading effects on neuroendocrine or immune responses of healthy conspecifics, and could affect individual behaviors, social dynamics, and pathogen spread.
format	article
author	Stephanie S. Gervasi Maryanne Opiekun Talia Martin Gary K. Beauchamp Bruce A. Kimball
author_facet	Stephanie S. Gervasi Maryanne Opiekun Talia Martin Gary K. Beauchamp Bruce A. Kimball
author_sort	Stephanie S. Gervasi
title	Sharing an environment with sick conspecifics alters odors of healthy animals
title_short	Sharing an environment with sick conspecifics alters odors of healthy animals
title_full	Sharing an environment with sick conspecifics alters odors of healthy animals
title_fullStr	Sharing an environment with sick conspecifics alters odors of healthy animals
title_full_unstemmed	Sharing an environment with sick conspecifics alters odors of healthy animals
title_sort	sharing an environment with sick conspecifics alters odors of healthy animals
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/d615abe8a0bb4914aaec4b8a40279539
work_keys_str_mv	AT stephaniesgervasi sharinganenvironmentwithsickconspecificsaltersodorsofhealthyanimals AT maryanneopiekun sharinganenvironmentwithsickconspecificsaltersodorsofhealthyanimals AT taliamartin sharinganenvironmentwithsickconspecificsaltersodorsofhealthyanimals AT garykbeauchamp sharinganenvironmentwithsickconspecificsaltersodorsofhealthyanimals AT bruceakimball sharinganenvironmentwithsickconspecificsaltersodorsofhealthyanimals
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Sharing an environment with sick conspecifics alters odors of healthy animals

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