ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance

ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance

Su Chul Jang et al. develop exoSTING, consisting of an engineered extracellular vesicle loaded with a potent cyclic dinucleotide (CDN) agonist of the STING pathway. They find that exoSTING shows more than 100-fold increased potency in in vivo tumor models and has increased tumor retention and lower...

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Autores principales: Su Chul Jang, Kyriakos D. Economides, Raymond J. Moniz, Chang Ling Sia, Nuruddeen Lewis, Christine McCoy, Tong Zi, Kelvin Zhang, Rane A. Harrison, Joanne Lim, Joyoti Dey, Marc Grenley, Katherine Kirwin, Nikki L. Ross, Raymond Bourdeau, Agata Villiger-Oberbek, Scott Estes, Ke Xu, Jorge Sanchez-Salazar, Kevin Dooley, William K. Dahlberg, Douglas E. Williams, Sriram Sathyanarayanan
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/d6164d29cedd4b8db922002838b3e600
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Sumario:Su Chul Jang et al. develop exoSTING, consisting of an engineered extracellular vesicle loaded with a potent cyclic dinucleotide (CDN) agonist of the STING pathway. They find that exoSTING shows more than 100-fold increased potency in in vivo tumor models and has increased tumor retention and lower levels of systemic inflammatory cytokine production as compared to free CDN.

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