ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance

Su Chul Jang et al. develop exoSTING, consisting of an engineered extracellular vesicle loaded with a potent cyclic dinucleotide (CDN) agonist of the STING pathway. They find that exoSTING shows more than 100-fold increased potency in in vivo tumor models and has increased tumor retention and lower...

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Autores principales:	Su Chul Jang, Kyriakos D. Economides, Raymond J. Moniz, Chang Ling Sia, Nuruddeen Lewis, Christine McCoy, Tong Zi, Kelvin Zhang, Rane A. Harrison, Joanne Lim, Joyoti Dey, Marc Grenley, Katherine Kirwin, Nikki L. Ross, Raymond Bourdeau, Agata Villiger-Oberbek, Scott Estes, Ke Xu, Jorge Sanchez-Salazar, Kevin Dooley, William K. Dahlberg, Douglas E. Williams, Sriram Sathyanarayanan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/d6164d29cedd4b8db922002838b3e600
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:d6164d29cedd4b8db922002838b3e6002021-12-02T16:45:14ZExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance10.1038/s42003-021-02004-52399-3642https://doaj.org/article/d6164d29cedd4b8db922002838b3e6002021-04-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02004-5https://doaj.org/toc/2399-3642Su Chul Jang et al. develop exoSTING, consisting of an engineered extracellular vesicle loaded with a potent cyclic dinucleotide (CDN) agonist of the STING pathway. They find that exoSTING shows more than 100-fold increased potency in in vivo tumor models and has increased tumor retention and lower levels of systemic inflammatory cytokine production as compared to free CDN.Su Chul JangKyriakos D. EconomidesRaymond J. MonizChang Ling SiaNuruddeen LewisChristine McCoyTong ZiKelvin ZhangRane A. HarrisonJoanne LimJoyoti DeyMarc GrenleyKatherine KirwinNikki L. RossRaymond BourdeauAgata Villiger-OberbekScott EstesKe XuJorge Sanchez-SalazarKevin DooleyWilliam K. DahlbergDouglas E. WilliamsSriram SathyanarayananNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Su Chul Jang Kyriakos D. Economides Raymond J. Moniz Chang Ling Sia Nuruddeen Lewis Christine McCoy Tong Zi Kelvin Zhang Rane A. Harrison Joanne Lim Joyoti Dey Marc Grenley Katherine Kirwin Nikki L. Ross Raymond Bourdeau Agata Villiger-Oberbek Scott Estes Ke Xu Jorge Sanchez-Salazar Kevin Dooley William K. Dahlberg Douglas E. Williams Sriram Sathyanarayanan ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
description	Su Chul Jang et al. develop exoSTING, consisting of an engineered extracellular vesicle loaded with a potent cyclic dinucleotide (CDN) agonist of the STING pathway. They find that exoSTING shows more than 100-fold increased potency in in vivo tumor models and has increased tumor retention and lower levels of systemic inflammatory cytokine production as compared to free CDN.
format	article
author	Su Chul Jang Kyriakos D. Economides Raymond J. Moniz Chang Ling Sia Nuruddeen Lewis Christine McCoy Tong Zi Kelvin Zhang Rane A. Harrison Joanne Lim Joyoti Dey Marc Grenley Katherine Kirwin Nikki L. Ross Raymond Bourdeau Agata Villiger-Oberbek Scott Estes Ke Xu Jorge Sanchez-Salazar Kevin Dooley William K. Dahlberg Douglas E. Williams Sriram Sathyanarayanan
author_facet	Su Chul Jang Kyriakos D. Economides Raymond J. Moniz Chang Ling Sia Nuruddeen Lewis Christine McCoy Tong Zi Kelvin Zhang Rane A. Harrison Joanne Lim Joyoti Dey Marc Grenley Katherine Kirwin Nikki L. Ross Raymond Bourdeau Agata Villiger-Oberbek Scott Estes Ke Xu Jorge Sanchez-Salazar Kevin Dooley William K. Dahlberg Douglas E. Williams Sriram Sathyanarayanan
author_sort	Su Chul Jang
title	ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
title_short	ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
title_full	ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
title_fullStr	ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
title_full_unstemmed	ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance
title_sort	exosting, an extracellular vesicle loaded with sting agonists, promotes tumor immune surveillance
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d6164d29cedd4b8db922002838b3e600
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ExoSTING, an extracellular vesicle loaded with STING agonists, promotes tumor immune surveillance

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