EVALUATION OF BIOLOGICAL ACTIVITY OF <I>Crotalaria Juncea</I> EXTRACTS THROUGH A <I>Drosophila melanogaster</I> MODEL

The disproportionate growth of world population has led the search methods to control pests that permit a rational and sustained production of food, which additionally ensure the conservation of ecosystems. The activity of extracts with different polarity obtained from C. juncea was evaluated using...

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Autores principales:	Giann C. PEÑALOZA, Carlos A. PELÁEZ J.
Formato:	article
Lenguaje:	EN
Publicado:	Universidad de Antioquia 2009
Materias:	Crotalaria juncea Drosophila melanogaster biological models Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
Acceso en línea:	https://doaj.org/article/d61797a4267d4f6a8659abca24bcfa36
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spelling	oai:doaj.org-article:d61797a4267d4f6a8659abca24bcfa362021-11-19T04:17:10ZEVALUATION OF BIOLOGICAL ACTIVITY OF <I>Crotalaria Juncea</I> EXTRACTS THROUGH A <I>Drosophila melanogaster</I> MODEL0121-40042145-2660https://doaj.org/article/d61797a4267d4f6a8659abca24bcfa362009-02-01T00:00:00Zhttps://revistas.udea.edu.co/index.php/vitae/article/view/801https://doaj.org/toc/0121-4004https://doaj.org/toc/2145-2660The disproportionate growth of world population has led the search methods to control pests that permit a rational and sustained production of food, which additionally ensure the conservation of ecosystems. The activity of extracts with different polarity obtained from C. juncea was evaluated using the biological model of Drosophila melanogaster. This model allows the identification and purification of active fractions, and allows establishing that these extracts exert two different inhibitory activities over the life cycle of Drosophila melanogaster. The first activity showed the reduction in the number of adults compared with the control group. The second activity caused the inhibition of the larval estate then it resulted in diminution of the pupal number. The use of the biological assay and spectroscopy techniques as Nuclear Magnetic Resonance, allowed the establishment that the structure of active principle of Crotalaria juncea is in agreement with a pyrrolizidinic alkaloid of retronecic type well known as Junceine. The use of biological model as quantitative analytical tool, allows the establishment of correlation between dosage and response variables. Giann C. PEÑALOZACarlos A. PELÁEZ J.Universidad de AntioquiaarticleCrotalariajunceaDrosophila melanogasterbiological modelsFood processing and manufactureTP368-456Pharmaceutical industryHD9665-9675ENVitae, Vol 15, Iss 2 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Crotalaria juncea Drosophila melanogaster biological models Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675
spellingShingle	Crotalaria juncea Drosophila melanogaster biological models Food processing and manufacture TP368-456 Pharmaceutical industry HD9665-9675 Giann C. PEÑALOZA Carlos A. PELÁEZ J. EVALUATION OF BIOLOGICAL ACTIVITY OF <I>Crotalaria Juncea</I> EXTRACTS THROUGH A <I>Drosophila melanogaster</I> MODEL
description	The disproportionate growth of world population has led the search methods to control pests that permit a rational and sustained production of food, which additionally ensure the conservation of ecosystems. The activity of extracts with different polarity obtained from C. juncea was evaluated using the biological model of Drosophila melanogaster. This model allows the identification and purification of active fractions, and allows establishing that these extracts exert two different inhibitory activities over the life cycle of Drosophila melanogaster. The first activity showed the reduction in the number of adults compared with the control group. The second activity caused the inhibition of the larval estate then it resulted in diminution of the pupal number. The use of the biological assay and spectroscopy techniques as Nuclear Magnetic Resonance, allowed the establishment that the structure of active principle of Crotalaria juncea is in agreement with a pyrrolizidinic alkaloid of retronecic type well known as Junceine. The use of biological model as quantitative analytical tool, allows the establishment of correlation between dosage and response variables.
format	article
author	Giann C. PEÑALOZA Carlos A. PELÁEZ J.
author_facet	Giann C. PEÑALOZA Carlos A. PELÁEZ J.
author_sort	Giann C. PEÑALOZA
title	EVALUATION OF BIOLOGICAL ACTIVITY OF <I>Crotalaria Juncea</I> EXTRACTS THROUGH A <I>Drosophila melanogaster</I> MODEL
title_short	EVALUATION OF BIOLOGICAL ACTIVITY OF <I>Crotalaria Juncea</I> EXTRACTS THROUGH A <I>Drosophila melanogaster</I> MODEL
title_full	EVALUATION OF BIOLOGICAL ACTIVITY OF <I>Crotalaria Juncea</I> EXTRACTS THROUGH A <I>Drosophila melanogaster</I> MODEL
title_fullStr	EVALUATION OF BIOLOGICAL ACTIVITY OF <I>Crotalaria Juncea</I> EXTRACTS THROUGH A <I>Drosophila melanogaster</I> MODEL
title_full_unstemmed	EVALUATION OF BIOLOGICAL ACTIVITY OF <I>Crotalaria Juncea</I> EXTRACTS THROUGH A <I>Drosophila melanogaster</I> MODEL
title_sort	evaluation of biological activity of <i>crotalaria juncea</i> extracts through a <i>drosophila melanogaster</i> model
publisher	Universidad de Antioquia
publishDate	2009
url	https://doaj.org/article/d61797a4267d4f6a8659abca24bcfa36
work_keys_str_mv	AT gianncpenaloza evaluationofbiologicalactivityoficrotalariajunceaiextractsthroughaidrosophilamelanogasterimodel AT carlosapelaezj evaluationofbiologicalactivityoficrotalariajunceaiextractsthroughaidrosophilamelanogasterimodel
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EVALUATION OF BIOLOGICAL ACTIVITY OF <I>Crotalaria Juncea</I> EXTRACTS THROUGH A <I>Drosophila melanogaster</I> MODEL

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