Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI

Iron oxide microparticles (MPIO) are better MRI contrast agents than nanoparticles, but are of limited clinical use as they are not degradable and so risk toxicity. Here the authors present an iron oxide microparticle MRI contrast agent with peptide linkers that enable degradation into non-toxic nan...

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Main Authors:	Francisco Perez-Balderas, Sander I. van Kasteren, Alaa A. A. Aljabali, Kim Wals, Sébastien Serres, Andrew Jefferson, Manuel Sarmiento Soto, Alexandre A. Khrapitchev, James R Larkin, Claire Bristow, Seung Seo Lee, Guillaume Bort, Filippo De Simone, Sandra J. Campbell, Robin P. Choudhury, Daniel C. Anthony, Nicola R. Sibson, Benjamin G. Davis
Format:	article
Language:	EN
Published:	Nature Portfolio 2017
Subjects:	Science Q
Online Access:	https://doaj.org/article/d6193834fc8f46f68e4a4160e6d4d903
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spelling	oai:doaj.org-article:d6193834fc8f46f68e4a4160e6d4d9032021-12-02T14:42:44ZCovalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI10.1038/ncomms142542041-1723https://doaj.org/article/d6193834fc8f46f68e4a4160e6d4d9032017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14254https://doaj.org/toc/2041-1723Iron oxide microparticles (MPIO) are better MRI contrast agents than nanoparticles, but are of limited clinical use as they are not degradable and so risk toxicity. Here the authors present an iron oxide microparticle MRI contrast agent with peptide linkers that enable degradation into non-toxic nanoparticlesin vivo.Francisco Perez-BalderasSander I. van KasterenAlaa A. A. AljabaliKim WalsSébastien SerresAndrew JeffersonManuel Sarmiento SotoAlexandre A. KhrapitchevJames R LarkinClaire BristowSeung Seo LeeGuillaume BortFilippo De SimoneSandra J. CampbellRobin P. ChoudhuryDaniel C. AnthonyNicola R. SibsonBenjamin G. DavisNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Francisco Perez-Balderas Sander I. van Kasteren Alaa A. A. Aljabali Kim Wals Sébastien Serres Andrew Jefferson Manuel Sarmiento Soto Alexandre A. Khrapitchev James R Larkin Claire Bristow Seung Seo Lee Guillaume Bort Filippo De Simone Sandra J. Campbell Robin P. Choudhury Daniel C. Anthony Nicola R. Sibson Benjamin G. Davis Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI
description	Iron oxide microparticles (MPIO) are better MRI contrast agents than nanoparticles, but are of limited clinical use as they are not degradable and so risk toxicity. Here the authors present an iron oxide microparticle MRI contrast agent with peptide linkers that enable degradation into non-toxic nanoparticlesin vivo.
format	article
author	Francisco Perez-Balderas Sander I. van Kasteren Alaa A. A. Aljabali Kim Wals Sébastien Serres Andrew Jefferson Manuel Sarmiento Soto Alexandre A. Khrapitchev James R Larkin Claire Bristow Seung Seo Lee Guillaume Bort Filippo De Simone Sandra J. Campbell Robin P. Choudhury Daniel C. Anthony Nicola R. Sibson Benjamin G. Davis
author_facet	Francisco Perez-Balderas Sander I. van Kasteren Alaa A. A. Aljabali Kim Wals Sébastien Serres Andrew Jefferson Manuel Sarmiento Soto Alexandre A. Khrapitchev James R Larkin Claire Bristow Seung Seo Lee Guillaume Bort Filippo De Simone Sandra J. Campbell Robin P. Choudhury Daniel C. Anthony Nicola R. Sibson Benjamin G. Davis
author_sort	Francisco Perez-Balderas
title	Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI
title_short	Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI
title_full	Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI
title_fullStr	Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI
title_full_unstemmed	Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI
title_sort	covalent assembly of nanoparticles as a peptidase-degradable platform for molecular mri
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d6193834fc8f46f68e4a4160e6d4d903
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Covalent assembly of nanoparticles as a peptidase-degradable platform for molecular MRI

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