Metabolic profiling of cytotoxic metabolites from five Tabebuia species supported by molecular correlation analysis

Abstract Tabebuia is the largest genus among the family Bignoniaceae. Tabebuia species are known for their high ornamental and curative value. Here, the cytotoxic potential of extracts from the leaves and stems of five Tabebuia species was analyzed. The highest activity was observed for T. rosea (Be...

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Autores principales:	Seham S. El-Hawary, Rabab Mohammed, Ahmed F. Tawfike, Sameh Fekry AbouZid, Marwa A. Taher, Usama Ramadan Abdelmohsen, Elham Amin
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Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d61c20555c1b448ab587ce0209549abd
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spelling	oai:doaj.org-article:d61c20555c1b448ab587ce0209549abd2021-12-02T14:26:13ZMetabolic profiling of cytotoxic metabolites from five Tabebuia species supported by molecular correlation analysis10.1038/s41598-021-87695-w2045-2322https://doaj.org/article/d61c20555c1b448ab587ce0209549abd2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87695-whttps://doaj.org/toc/2045-2322Abstract Tabebuia is the largest genus among the family Bignoniaceae. Tabebuia species are known for their high ornamental and curative value. Here, the cytotoxic potential of extracts from the leaves and stems of five Tabebuia species was analyzed. The highest activity was observed for T. rosea (Bertol.) DC. stem extract against HepG2 cell line (IC50 4.7 µg/mL), T. pallida L. stem extract against MCF-7 cell line (IC50 6.3 µg/mL), and T. pulcherrima stem extract against CACO2 cell line (IC50 2.6 µg/mL). Metabolic profiling of the ten extracts using liquid chromatography–high-resolution mass spectrometry for dereplication purposes led to annotation of forty compounds belonging to different chemical classes. Among the annotated compounds, irridoids represent the major class. Principle component analysis (PCA) was applied to test the similarity and variability among the tested species and the score plot showed similar chemical profiling between the leaves and stems of both T. pulcherrima and T. pallida L. and unique chemical profiling among T. rosea (Bertol.) DC., T. argentea Britton, and T. guayacan (Seem.) Hemsl. leaf extracts and the stem extract of T. rosea (Bertol.) DC. Additionally, a molecular correlation analysis was used to annotate the bioactive cytotoxic metabolites in the extracts and correlate between their chemical and biological profiles.Seham S. El-HawaryRabab MohammedAhmed F. TawfikeSameh Fekry AbouZidMarwa A. TaherUsama Ramadan AbdelmohsenElham AminNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Seham S. El-Hawary Rabab Mohammed Ahmed F. Tawfike Sameh Fekry AbouZid Marwa A. Taher Usama Ramadan Abdelmohsen Elham Amin Metabolic profiling of cytotoxic metabolites from five Tabebuia species supported by molecular correlation analysis
description	Abstract Tabebuia is the largest genus among the family Bignoniaceae. Tabebuia species are known for their high ornamental and curative value. Here, the cytotoxic potential of extracts from the leaves and stems of five Tabebuia species was analyzed. The highest activity was observed for T. rosea (Bertol.) DC. stem extract against HepG2 cell line (IC50 4.7 µg/mL), T. pallida L. stem extract against MCF-7 cell line (IC50 6.3 µg/mL), and T. pulcherrima stem extract against CACO2 cell line (IC50 2.6 µg/mL). Metabolic profiling of the ten extracts using liquid chromatography–high-resolution mass spectrometry for dereplication purposes led to annotation of forty compounds belonging to different chemical classes. Among the annotated compounds, irridoids represent the major class. Principle component analysis (PCA) was applied to test the similarity and variability among the tested species and the score plot showed similar chemical profiling between the leaves and stems of both T. pulcherrima and T. pallida L. and unique chemical profiling among T. rosea (Bertol.) DC., T. argentea Britton, and T. guayacan (Seem.) Hemsl. leaf extracts and the stem extract of T. rosea (Bertol.) DC. Additionally, a molecular correlation analysis was used to annotate the bioactive cytotoxic metabolites in the extracts and correlate between their chemical and biological profiles.
format	article
author	Seham S. El-Hawary Rabab Mohammed Ahmed F. Tawfike Sameh Fekry AbouZid Marwa A. Taher Usama Ramadan Abdelmohsen Elham Amin
author_facet	Seham S. El-Hawary Rabab Mohammed Ahmed F. Tawfike Sameh Fekry AbouZid Marwa A. Taher Usama Ramadan Abdelmohsen Elham Amin
author_sort	Seham S. El-Hawary
title	Metabolic profiling of cytotoxic metabolites from five Tabebuia species supported by molecular correlation analysis
title_short	Metabolic profiling of cytotoxic metabolites from five Tabebuia species supported by molecular correlation analysis
title_full	Metabolic profiling of cytotoxic metabolites from five Tabebuia species supported by molecular correlation analysis
title_fullStr	Metabolic profiling of cytotoxic metabolites from five Tabebuia species supported by molecular correlation analysis
title_full_unstemmed	Metabolic profiling of cytotoxic metabolites from five Tabebuia species supported by molecular correlation analysis
title_sort	metabolic profiling of cytotoxic metabolites from five tabebuia species supported by molecular correlation analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d61c20555c1b448ab587ce0209549abd
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Metabolic profiling of cytotoxic metabolites from five Tabebuia species supported by molecular correlation analysis

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