A STAT3-based gene signature stratifies glioma patients for targeted therapy

STAT3 activates distinct transcriptional programmes within cancer cells. In this study, the authors find that, in glioma, a STAT3-mediated expression signature can stratify patients for targeted precision therapy.

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Autores principales:	Melanie Si Yan Tan, Edwin Sandanaraj, Yuk Kien Chong, See Wee Lim, Lynnette Wei Hsien Koh, Wai Hoe Ng, Nguan Soon Tan, Patrick Tan, Beng Ti Ang, Carol Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d61c46f20a3c44179f855b1383771751
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spelling	oai:doaj.org-article:d61c46f20a3c44179f855b13837717512021-12-02T14:39:41ZA STAT3-based gene signature stratifies glioma patients for targeted therapy10.1038/s41467-019-11614-x2041-1723https://doaj.org/article/d61c46f20a3c44179f855b13837717512019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11614-xhttps://doaj.org/toc/2041-1723STAT3 activates distinct transcriptional programmes within cancer cells. In this study, the authors find that, in glioma, a STAT3-mediated expression signature can stratify patients for targeted precision therapy.Melanie Si Yan TanEdwin SandanarajYuk Kien ChongSee Wee LimLynnette Wei Hsien KohWai Hoe NgNguan Soon TanPatrick TanBeng Ti AngCarol TangNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Melanie Si Yan Tan Edwin Sandanaraj Yuk Kien Chong See Wee Lim Lynnette Wei Hsien Koh Wai Hoe Ng Nguan Soon Tan Patrick Tan Beng Ti Ang Carol Tang A STAT3-based gene signature stratifies glioma patients for targeted therapy
description	STAT3 activates distinct transcriptional programmes within cancer cells. In this study, the authors find that, in glioma, a STAT3-mediated expression signature can stratify patients for targeted precision therapy.
format	article
author	Melanie Si Yan Tan Edwin Sandanaraj Yuk Kien Chong See Wee Lim Lynnette Wei Hsien Koh Wai Hoe Ng Nguan Soon Tan Patrick Tan Beng Ti Ang Carol Tang
author_facet	Melanie Si Yan Tan Edwin Sandanaraj Yuk Kien Chong See Wee Lim Lynnette Wei Hsien Koh Wai Hoe Ng Nguan Soon Tan Patrick Tan Beng Ti Ang Carol Tang
author_sort	Melanie Si Yan Tan
title	A STAT3-based gene signature stratifies glioma patients for targeted therapy
title_short	A STAT3-based gene signature stratifies glioma patients for targeted therapy
title_full	A STAT3-based gene signature stratifies glioma patients for targeted therapy
title_fullStr	A STAT3-based gene signature stratifies glioma patients for targeted therapy
title_full_unstemmed	A STAT3-based gene signature stratifies glioma patients for targeted therapy
title_sort	stat3-based gene signature stratifies glioma patients for targeted therapy
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/d61c46f20a3c44179f855b1383771751
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A STAT3-based gene signature stratifies glioma patients for targeted therapy

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