Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis

Naeti Suksomboon,1 Nalinee Poolsup,2 Htoo Darli Ko Ko1 1Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon-Pathom, Thailand Objective: To perform a systematic review and meta-analysis of rando...

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Autores principales:	Suksomboon N, Poolsup N, Darli Ko Ko H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	vitamin K insulin resistance meta-analysis systematic review Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/d61dc386f54c4e5580ff116b4566a9b8
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spelling	oai:doaj.org-article:d61dc386f54c4e5580ff116b4566a9b82021-12-02T00:20:03ZEffect of vitamin K supplementation on insulin sensitivity: a meta-analysis1178-7007https://doaj.org/article/d61dc386f54c4e5580ff116b4566a9b82017-05-01T00:00:00Zhttps://www.dovepress.com/effect-of-vitamin-k-supplementation-on-insulin-sensitivity-a-meta-anal-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Naeti Suksomboon,1 Nalinee Poolsup,2 Htoo Darli Ko Ko1 1Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon-Pathom, Thailand Objective: To perform a systematic review and meta-analysis of randomized, placebo-controlled trials to assess the effect of vitamin K supplementation on insulin sensitivity.Data sources: MEDLINE, the Cochrane Library, CINAHL, Web of Science, Scopus, clinicaltrials.gov, and clinicaltrialresults.org were searched up to January 2017. Reference lists of related papers were also scanned.Study selection: Randomized controlled trials were selected if they compared vitamin K supplementation with placebo or no treatment and reported homeostasis model assessment of insulin resistance, fasting plasma glucose, fasting plasma insulin, C-reactive protein, adiponectin, leptin, or interleukin-6 levels.Data extraction: Data extraction and study quality assessment were performed independently by two investigators using a standardized data extraction form. Any inconsistencies were resolved by a third reviewer. Effect estimates were pooled using inverse-variance weighted method. Heterogeneity was assessed by the I2 and Q statistic.Results: A total of eight trials involving 1,077 participants met the inclusion criteria. A wide variety of participants were enrolled, including older men, postmenopausal women, prediabetic premenopausal women, and participants with a history of diabetes, hypertension, or vascular disease. Vitamin K1 and vitamin K2 (MK-4 and MK-7 subtypes) were assessed. Supplementation period ranged from 4 weeks to 3 years. Vitamin K supplementation did not affect insulin sensitivity as measured by homeostasis model assessment of insulin resistance, fasting plasma glucose, fasting plasma insulin, C-reactive protein, adiponectin, leptin, and interleukin-6 levels.Conclusion: Our analysis suggests no effect of vitamin K supplementation on insulin sensitivity. Keywords: vitamin K, insulin resistance, meta-analysis, systematic reviewSuksomboon NPoolsup NDarli Ko Ko HDove Medical Pressarticlevitamin Kinsulin resistancemeta-analysissystematic reviewSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 10, Pp 169-177 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	vitamin K insulin resistance meta-analysis systematic review Specialties of internal medicine RC581-951
spellingShingle	vitamin K insulin resistance meta-analysis systematic review Specialties of internal medicine RC581-951 Suksomboon N Poolsup N Darli Ko Ko H Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis
description	Naeti Suksomboon,1 Nalinee Poolsup,2 Htoo Darli Ko Ko1 1Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand; 2Department of Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon-Pathom, Thailand Objective: To perform a systematic review and meta-analysis of randomized, placebo-controlled trials to assess the effect of vitamin K supplementation on insulin sensitivity.Data sources: MEDLINE, the Cochrane Library, CINAHL, Web of Science, Scopus, clinicaltrials.gov, and clinicaltrialresults.org were searched up to January 2017. Reference lists of related papers were also scanned.Study selection: Randomized controlled trials were selected if they compared vitamin K supplementation with placebo or no treatment and reported homeostasis model assessment of insulin resistance, fasting plasma glucose, fasting plasma insulin, C-reactive protein, adiponectin, leptin, or interleukin-6 levels.Data extraction: Data extraction and study quality assessment were performed independently by two investigators using a standardized data extraction form. Any inconsistencies were resolved by a third reviewer. Effect estimates were pooled using inverse-variance weighted method. Heterogeneity was assessed by the I2 and Q statistic.Results: A total of eight trials involving 1,077 participants met the inclusion criteria. A wide variety of participants were enrolled, including older men, postmenopausal women, prediabetic premenopausal women, and participants with a history of diabetes, hypertension, or vascular disease. Vitamin K1 and vitamin K2 (MK-4 and MK-7 subtypes) were assessed. Supplementation period ranged from 4 weeks to 3 years. Vitamin K supplementation did not affect insulin sensitivity as measured by homeostasis model assessment of insulin resistance, fasting plasma glucose, fasting plasma insulin, C-reactive protein, adiponectin, leptin, and interleukin-6 levels.Conclusion: Our analysis suggests no effect of vitamin K supplementation on insulin sensitivity. Keywords: vitamin K, insulin resistance, meta-analysis, systematic review
format	article
author	Suksomboon N Poolsup N Darli Ko Ko H
author_facet	Suksomboon N Poolsup N Darli Ko Ko H
author_sort	Suksomboon N
title	Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis
title_short	Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis
title_full	Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis
title_fullStr	Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis
title_full_unstemmed	Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis
title_sort	effect of vitamin k supplementation on insulin sensitivity: a meta-analysis
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/d61dc386f54c4e5580ff116b4566a9b8
work_keys_str_mv	AT suksomboonn effectofvitaminksupplementationoninsulinsensitivityametaanalysis AT poolsupn effectofvitaminksupplementationoninsulinsensitivityametaanalysis AT darlikokoh effectofvitaminksupplementationoninsulinsensitivityametaanalysis
_version_	1718403832402149376

Effect of vitamin K supplementation on insulin sensitivity: a meta-analysis

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