Relationship between intraventricular hemorrhage and acute kidney injury in premature infants and its effect on neonatal mortality

Abstract Intraventricular hemorrhage (IVH) and acute kidney injury (AKI) are important neonatal morbidities in premature infants. This study aimed to investigate the relationship between IVH and AKI in premature infants and whether this association affects the incidence of neonatal mortality. Infant...

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Autores principales:	Mountasser M. Al-Mouqdad, Roya Huseynova, Thanaa M. Khalil, Yasmeen S. Asfour, Suzan S. Asfour
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d6246c9374fb43108da1d1f39885b0b5
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spelling	oai:doaj.org-article:d6246c9374fb43108da1d1f39885b0b52021-12-02T17:45:12ZRelationship between intraventricular hemorrhage and acute kidney injury in premature infants and its effect on neonatal mortality10.1038/s41598-021-92746-32045-2322https://doaj.org/article/d6246c9374fb43108da1d1f39885b0b52021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92746-3https://doaj.org/toc/2045-2322Abstract Intraventricular hemorrhage (IVH) and acute kidney injury (AKI) are important neonatal morbidities in premature infants. This study aimed to investigate the relationship between IVH and AKI in premature infants and whether this association affects the incidence of neonatal mortality. Infants [gestational age (GA) ≤ 32 weeks; birth weight (BW) < 1500 g] were retrospectively evaluated in a large tertiary neonatal intensive care unit. Of 710 premature infants, 268 (37.7%) developed AKI. Infants with IVH were more likely to have AKI than those without IVH. Infants with severe IVH had a higher incidence of AKI than infants with mild IVH. Infants younger than 28 weeks with IVH were more likely to have AKI than those without IVH. An association between IVH grades and AKI stages was observed in the overall study population, in infants with GA < 28 weeks, and in infants with GA between 28 and 32 weeks. Mortality was increased 1.5 times in infants with IVH and AKI compared with that in infants with IVH but without AKI. Furthermore, mortality was increased in infants with IVH and AKI compared with infants without IVH or AKI. This study shows a direct relationship between the severity of IVH and the degree of AKI; both IVH and AKI increase the incidence of neonatal mortality.Mountasser M. Al-MouqdadRoya HuseynovaThanaa M. KhalilYasmeen S. AsfourSuzan S. AsfourNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Mountasser M. Al-Mouqdad Roya Huseynova Thanaa M. Khalil Yasmeen S. Asfour Suzan S. Asfour Relationship between intraventricular hemorrhage and acute kidney injury in premature infants and its effect on neonatal mortality
description	Abstract Intraventricular hemorrhage (IVH) and acute kidney injury (AKI) are important neonatal morbidities in premature infants. This study aimed to investigate the relationship between IVH and AKI in premature infants and whether this association affects the incidence of neonatal mortality. Infants [gestational age (GA) ≤ 32 weeks; birth weight (BW) < 1500 g] were retrospectively evaluated in a large tertiary neonatal intensive care unit. Of 710 premature infants, 268 (37.7%) developed AKI. Infants with IVH were more likely to have AKI than those without IVH. Infants with severe IVH had a higher incidence of AKI than infants with mild IVH. Infants younger than 28 weeks with IVH were more likely to have AKI than those without IVH. An association between IVH grades and AKI stages was observed in the overall study population, in infants with GA < 28 weeks, and in infants with GA between 28 and 32 weeks. Mortality was increased 1.5 times in infants with IVH and AKI compared with that in infants with IVH but without AKI. Furthermore, mortality was increased in infants with IVH and AKI compared with infants without IVH or AKI. This study shows a direct relationship between the severity of IVH and the degree of AKI; both IVH and AKI increase the incidence of neonatal mortality.
format	article
author	Mountasser M. Al-Mouqdad Roya Huseynova Thanaa M. Khalil Yasmeen S. Asfour Suzan S. Asfour
author_facet	Mountasser M. Al-Mouqdad Roya Huseynova Thanaa M. Khalil Yasmeen S. Asfour Suzan S. Asfour
author_sort	Mountasser M. Al-Mouqdad
title	Relationship between intraventricular hemorrhage and acute kidney injury in premature infants and its effect on neonatal mortality
title_short	Relationship between intraventricular hemorrhage and acute kidney injury in premature infants and its effect on neonatal mortality
title_full	Relationship between intraventricular hemorrhage and acute kidney injury in premature infants and its effect on neonatal mortality
title_fullStr	Relationship between intraventricular hemorrhage and acute kidney injury in premature infants and its effect on neonatal mortality
title_full_unstemmed	Relationship between intraventricular hemorrhage and acute kidney injury in premature infants and its effect on neonatal mortality
title_sort	relationship between intraventricular hemorrhage and acute kidney injury in premature infants and its effect on neonatal mortality
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d6246c9374fb43108da1d1f39885b0b5
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Relationship between intraventricular hemorrhage and acute kidney injury in premature infants and its effect on neonatal mortality

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