Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease

Long-term intake of potential zinc-chelating drugs may cause zinc deficiency. We postulated that zinc deficiency in Parkinson’s disease (PD) patients was related to the intake of drugs such as levodopa. We investigated the relationship between zinc levels and levodopa administration period, dosage,...

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Autores principales:	Hirofumi Matsuyama, Keita Matsuura, Hidehiro Ishikawa, Yoshinori Hirata, Natsuko Kato, Atsushi Niwa, Yugo Narita, Hidekazu Tomimoto
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	zinc deficiency zinc-chelating action dosing frequency of levodopa psychiatric symptom Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/d627a5ca5ea547d29a12841cfb976ecf
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spelling	oai:doaj.org-article:d627a5ca5ea547d29a12841cfb976ecf2021-11-25T18:36:52ZCorrelation between Serum Zinc Levels and Levodopa in Parkinson’s Disease10.3390/nu131141142072-6643https://doaj.org/article/d627a5ca5ea547d29a12841cfb976ecf2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4114https://doaj.org/toc/2072-6643Long-term intake of potential zinc-chelating drugs may cause zinc deficiency. We postulated that zinc deficiency in Parkinson’s disease (PD) patients was related to the intake of drugs such as levodopa. We investigated the relationship between zinc levels and levodopa administration period, dosage, and symptoms of zinc deficiency in PD patients. We measured serum zinc levels and analyzed correlations between serum zinc levels, the levodopa oral administration period, dosage, dosing frequency, and zinc deficiency symptoms including taste disorders. Data analyses were performed using Spearman’s rank correlation coefficient. The mean serum zinc level was 60.5 ± 11.6 μg/dL. The mean administration period for levodopa was 8.0 ± 5.5 years, mean administration frequency 3.4 ± 0.9 times/d, and mean administration dose 420.6 ± 237.1 mg/d. Negative correlations between zinc levels and levodopa dosage and dosing frequency were found. Multiple regression analysis showed a significant correlation with the frequency of levodopa (β = −0.360, <i>p</i> = 0.007). No significant change in clinical symptoms was observed after zinc administration, but anxiety tended to improve. Our results indicated that frequent levodopa administration strongly influenced serum zinc levels which may have alleviating effects on psychiatric symptoms; therefore, preventing zinc deficiency can be important during PD treatment.Hirofumi MatsuyamaKeita MatsuuraHidehiro IshikawaYoshinori HirataNatsuko KatoAtsushi NiwaYugo NaritaHidekazu TomimotoMDPI AGarticlezinc deficiencyzinc-chelating actiondosing frequency of levodopapsychiatric symptomNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4114, p 4114 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	zinc deficiency zinc-chelating action dosing frequency of levodopa psychiatric symptom Nutrition. Foods and food supply TX341-641
spellingShingle	zinc deficiency zinc-chelating action dosing frequency of levodopa psychiatric symptom Nutrition. Foods and food supply TX341-641 Hirofumi Matsuyama Keita Matsuura Hidehiro Ishikawa Yoshinori Hirata Natsuko Kato Atsushi Niwa Yugo Narita Hidekazu Tomimoto Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease
description	Long-term intake of potential zinc-chelating drugs may cause zinc deficiency. We postulated that zinc deficiency in Parkinson’s disease (PD) patients was related to the intake of drugs such as levodopa. We investigated the relationship between zinc levels and levodopa administration period, dosage, and symptoms of zinc deficiency in PD patients. We measured serum zinc levels and analyzed correlations between serum zinc levels, the levodopa oral administration period, dosage, dosing frequency, and zinc deficiency symptoms including taste disorders. Data analyses were performed using Spearman’s rank correlation coefficient. The mean serum zinc level was 60.5 ± 11.6 μg/dL. The mean administration period for levodopa was 8.0 ± 5.5 years, mean administration frequency 3.4 ± 0.9 times/d, and mean administration dose 420.6 ± 237.1 mg/d. Negative correlations between zinc levels and levodopa dosage and dosing frequency were found. Multiple regression analysis showed a significant correlation with the frequency of levodopa (β = −0.360, <i>p</i> = 0.007). No significant change in clinical symptoms was observed after zinc administration, but anxiety tended to improve. Our results indicated that frequent levodopa administration strongly influenced serum zinc levels which may have alleviating effects on psychiatric symptoms; therefore, preventing zinc deficiency can be important during PD treatment.
format	article
author	Hirofumi Matsuyama Keita Matsuura Hidehiro Ishikawa Yoshinori Hirata Natsuko Kato Atsushi Niwa Yugo Narita Hidekazu Tomimoto
author_facet	Hirofumi Matsuyama Keita Matsuura Hidehiro Ishikawa Yoshinori Hirata Natsuko Kato Atsushi Niwa Yugo Narita Hidekazu Tomimoto
author_sort	Hirofumi Matsuyama
title	Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease
title_short	Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease
title_full	Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease
title_fullStr	Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease
title_full_unstemmed	Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease
title_sort	correlation between serum zinc levels and levodopa in parkinson’s disease
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/d627a5ca5ea547d29a12841cfb976ecf
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Correlation between Serum Zinc Levels and Levodopa in Parkinson’s Disease

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