Polymers Blending as Release Modulating Tool in Drug Delivery

Different polymeric materials have been used as drug delivery vehicles for decades. Natural, semisynthetic, and synthetic polymers each have their own specific characteristics and, due to the physicochemical limitations of each polymer, tuning the release rate and targeting the active ingredient to...

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Autores principales:	Parisa Ghasemiyeh, Soliman Mohammadi-Samani
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	polymers blending core-shell polymeric carriers block copolymers physical mixtures release profile drug delivery Technology T
Acceso en línea:	https://doaj.org/article/d6290176fe834fad8f42410205e508e9
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spelling	oai:doaj.org-article:d6290176fe834fad8f42410205e508e92021-11-09T05:11:46ZPolymers Blending as Release Modulating Tool in Drug Delivery2296-801610.3389/fmats.2021.752813https://doaj.org/article/d6290176fe834fad8f42410205e508e92021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmats.2021.752813/fullhttps://doaj.org/toc/2296-8016Different polymeric materials have been used as drug delivery vehicles for decades. Natural, semisynthetic, and synthetic polymers each have their own specific characteristics and, due to the physicochemical limitations of each polymer, tuning the release rate and targeting the active ingredient to a specific organ or site of action is a complicated task for pharmaceutical scientists. In this regard, polymer blending has been considered as an attractive approach to fabricate novel and unique drug delivery systems with modified physical and/or chemical characteristics. There are three major polymer blending approaches that are used for drug delivery purposes: physical mixtures, core-shell model, and block copolymer model. Each of these types of polymer blends could significantly affect the loading capacities and the kinetics of drug release from the relevant formulations. Drug release from these blended polymers can be tuned through the changes in temperature and pH of the environment, and physiochemical properties of the target organs. Furthermore, the possible molecular interactions among polymers and drug molecules can significantly affect the drug release profile from these blended polymeric micro- and nanocarriers. In this review, first of all, different types of polymers and their various applications in biomedical sciences have been discussed and smart or stimuli responsive polymers are introduced and categorized based on their nature. Then, the purpose of polymer blending in drug delivery systems has been discussed. Different types of polymer blends including physical mixtures, core-shell polymeric carriers, and block copolymers have been summarized with focus on the effect of polymer blending on encapsulated drug release profiles. Finally, the consequence of each blending approach on drug release profile and kinetics of drug release have been mentioned in tabular format.Parisa GhasemiyehParisa GhasemiyehSoliman Mohammadi-SamaniSoliman Mohammadi-SamaniFrontiers Media S.A.articlepolymers blendingcore-shell polymeric carriersblock copolymersphysical mixturesrelease profiledrug deliveryTechnologyTENFrontiers in Materials, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	polymers blending core-shell polymeric carriers block copolymers physical mixtures release profile drug delivery Technology T
spellingShingle	polymers blending core-shell polymeric carriers block copolymers physical mixtures release profile drug delivery Technology T Parisa Ghasemiyeh Parisa Ghasemiyeh Soliman Mohammadi-Samani Soliman Mohammadi-Samani Polymers Blending as Release Modulating Tool in Drug Delivery
description	Different polymeric materials have been used as drug delivery vehicles for decades. Natural, semisynthetic, and synthetic polymers each have their own specific characteristics and, due to the physicochemical limitations of each polymer, tuning the release rate and targeting the active ingredient to a specific organ or site of action is a complicated task for pharmaceutical scientists. In this regard, polymer blending has been considered as an attractive approach to fabricate novel and unique drug delivery systems with modified physical and/or chemical characteristics. There are three major polymer blending approaches that are used for drug delivery purposes: physical mixtures, core-shell model, and block copolymer model. Each of these types of polymer blends could significantly affect the loading capacities and the kinetics of drug release from the relevant formulations. Drug release from these blended polymers can be tuned through the changes in temperature and pH of the environment, and physiochemical properties of the target organs. Furthermore, the possible molecular interactions among polymers and drug molecules can significantly affect the drug release profile from these blended polymeric micro- and nanocarriers. In this review, first of all, different types of polymers and their various applications in biomedical sciences have been discussed and smart or stimuli responsive polymers are introduced and categorized based on their nature. Then, the purpose of polymer blending in drug delivery systems has been discussed. Different types of polymer blends including physical mixtures, core-shell polymeric carriers, and block copolymers have been summarized with focus on the effect of polymer blending on encapsulated drug release profiles. Finally, the consequence of each blending approach on drug release profile and kinetics of drug release have been mentioned in tabular format.
format	article
author	Parisa Ghasemiyeh Parisa Ghasemiyeh Soliman Mohammadi-Samani Soliman Mohammadi-Samani
author_facet	Parisa Ghasemiyeh Parisa Ghasemiyeh Soliman Mohammadi-Samani Soliman Mohammadi-Samani
author_sort	Parisa Ghasemiyeh
title	Polymers Blending as Release Modulating Tool in Drug Delivery
title_short	Polymers Blending as Release Modulating Tool in Drug Delivery
title_full	Polymers Blending as Release Modulating Tool in Drug Delivery
title_fullStr	Polymers Blending as Release Modulating Tool in Drug Delivery
title_full_unstemmed	Polymers Blending as Release Modulating Tool in Drug Delivery
title_sort	polymers blending as release modulating tool in drug delivery
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/d6290176fe834fad8f42410205e508e9
work_keys_str_mv	AT parisaghasemiyeh polymersblendingasreleasemodulatingtoolindrugdelivery AT parisaghasemiyeh polymersblendingasreleasemodulatingtoolindrugdelivery AT solimanmohammadisamani polymersblendingasreleasemodulatingtoolindrugdelivery AT solimanmohammadisamani polymersblendingasreleasemodulatingtoolindrugdelivery
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Polymers Blending as Release Modulating Tool in Drug Delivery

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