Immune checkpoint molecule expression is altered in the skin and peripheral blood in vasculitis

Abstract Dysfunction of immunoinhibitory signals and persistent T cell activation reportedly play important roles in the development of vasculitis. The skin is one of the most accessible organs, and it is suitable for the characterization of immune cell signatures. However, the inhibitory checkpoint...

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Autores principales:	Chie Miyabe, Yupeng Dong, Takaharu Ikeda, Kazuo Takahashi, Yoshishige Miyabe, Tamihiro Kawakami
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/d62971d8fd3544cbac7a12184d4cb702
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spelling	oai:doaj.org-article:d62971d8fd3544cbac7a12184d4cb7022021-12-02T18:07:52ZImmune checkpoint molecule expression is altered in the skin and peripheral blood in vasculitis10.1038/s41598-021-99558-52045-2322https://doaj.org/article/d62971d8fd3544cbac7a12184d4cb7022021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99558-5https://doaj.org/toc/2045-2322Abstract Dysfunction of immunoinhibitory signals and persistent T cell activation reportedly play important roles in the development of vasculitis. The skin is one of the most accessible organs, and it is suitable for the characterization of immune cell signatures. However, the inhibitory checkpoint molecules in the skin and their relevance to vasculitis have not been studied. Here, we investigated the profile of immune checkpoint molecules in the skin and peripheral blood of patients with vasculitis and healthy donors. We found that some of the inhibitory checkpoint molecules, including programmed cell death 1 receptor (PD-1), were elevated in T-cells in the blood of patients with systemic and cutaneous vasculitis. In addition, programmed death-ligand 1 (PD-L1) expression was elevated in the skin of patients with cutaneous vasculitis. Histologically, PD-L1 was highly expressed in the vessels in the skin along with CD4+ and CD8+ T-cell infiltration in patients with cutaneous vasculitis. Notably, plasma soluble PD-L1 levels were increased, and these correlated with C-reactive protein in patients with systemic vasculitis. Our findings suggest that inhibitory checkpoint molecules might be differentially modulated in the skin and peripheral blood of patients with vasculitis, and that the alteration of the PD-L1/PD-1 axis may be associated with the regulation of T-cell activation in vasculitis.Chie MiyabeYupeng DongTakaharu IkedaKazuo TakahashiYoshishige MiyabeTamihiro KawakamiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chie Miyabe Yupeng Dong Takaharu Ikeda Kazuo Takahashi Yoshishige Miyabe Tamihiro Kawakami Immune checkpoint molecule expression is altered in the skin and peripheral blood in vasculitis
description	Abstract Dysfunction of immunoinhibitory signals and persistent T cell activation reportedly play important roles in the development of vasculitis. The skin is one of the most accessible organs, and it is suitable for the characterization of immune cell signatures. However, the inhibitory checkpoint molecules in the skin and their relevance to vasculitis have not been studied. Here, we investigated the profile of immune checkpoint molecules in the skin and peripheral blood of patients with vasculitis and healthy donors. We found that some of the inhibitory checkpoint molecules, including programmed cell death 1 receptor (PD-1), were elevated in T-cells in the blood of patients with systemic and cutaneous vasculitis. In addition, programmed death-ligand 1 (PD-L1) expression was elevated in the skin of patients with cutaneous vasculitis. Histologically, PD-L1 was highly expressed in the vessels in the skin along with CD4+ and CD8+ T-cell infiltration in patients with cutaneous vasculitis. Notably, plasma soluble PD-L1 levels were increased, and these correlated with C-reactive protein in patients with systemic vasculitis. Our findings suggest that inhibitory checkpoint molecules might be differentially modulated in the skin and peripheral blood of patients with vasculitis, and that the alteration of the PD-L1/PD-1 axis may be associated with the regulation of T-cell activation in vasculitis.
format	article
author	Chie Miyabe Yupeng Dong Takaharu Ikeda Kazuo Takahashi Yoshishige Miyabe Tamihiro Kawakami
author_facet	Chie Miyabe Yupeng Dong Takaharu Ikeda Kazuo Takahashi Yoshishige Miyabe Tamihiro Kawakami
author_sort	Chie Miyabe
title	Immune checkpoint molecule expression is altered in the skin and peripheral blood in vasculitis
title_short	Immune checkpoint molecule expression is altered in the skin and peripheral blood in vasculitis
title_full	Immune checkpoint molecule expression is altered in the skin and peripheral blood in vasculitis
title_fullStr	Immune checkpoint molecule expression is altered in the skin and peripheral blood in vasculitis
title_full_unstemmed	Immune checkpoint molecule expression is altered in the skin and peripheral blood in vasculitis
title_sort	immune checkpoint molecule expression is altered in the skin and peripheral blood in vasculitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d62971d8fd3544cbac7a12184d4cb702
work_keys_str_mv	AT chiemiyabe immunecheckpointmoleculeexpressionisalteredintheskinandperipheralbloodinvasculitis AT yupengdong immunecheckpointmoleculeexpressionisalteredintheskinandperipheralbloodinvasculitis AT takaharuikeda immunecheckpointmoleculeexpressionisalteredintheskinandperipheralbloodinvasculitis AT kazuotakahashi immunecheckpointmoleculeexpressionisalteredintheskinandperipheralbloodinvasculitis AT yoshishigemiyabe immunecheckpointmoleculeexpressionisalteredintheskinandperipheralbloodinvasculitis AT tamihirokawakami immunecheckpointmoleculeexpressionisalteredintheskinandperipheralbloodinvasculitis
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Immune checkpoint molecule expression is altered in the skin and peripheral blood in vasculitis

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