Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras

Yeast and cancer cells both favor sugar fermentation in aerobic conditions. Here the authors describe a conserved mechanism from yeast to mammals where the glycolysis intermediate fructose-1,6-bisphosphate binds Cdc25/Sos1 and couples increased glycolytic flux to increased Ras proto-oncoprotein acti...

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Autores principales:	Ken Peeters, Frederik Van Leemputte, Baptiste Fischer, Beatriz M. Bonini, Hector Quezada, Maksym Tsytlonok, Dorien Haesen, Ward Vanthienen, Nuno Bernardes, Carmen Bravo Gonzalez-Blas, Veerle Janssens, Peter Tompa, Wim Versées, Johan M. Thevelein
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d62a394b1ae143ca9a071cacf8de2008
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spelling	oai:doaj.org-article:d62a394b1ae143ca9a071cacf8de20082021-12-02T15:39:03ZFructose-1,6-bisphosphate couples glycolytic flux to activation of Ras10.1038/s41467-017-01019-z2041-1723https://doaj.org/article/d62a394b1ae143ca9a071cacf8de20082017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01019-zhttps://doaj.org/toc/2041-1723Yeast and cancer cells both favor sugar fermentation in aerobic conditions. Here the authors describe a conserved mechanism from yeast to mammals where the glycolysis intermediate fructose-1,6-bisphosphate binds Cdc25/Sos1 and couples increased glycolytic flux to increased Ras proto-oncoprotein activity.Ken PeetersFrederik Van LeemputteBaptiste FischerBeatriz M. BoniniHector QuezadaMaksym TsytlonokDorien HaesenWard VanthienenNuno BernardesCarmen Bravo Gonzalez-BlasVeerle JanssensPeter TompaWim VerséesJohan M. TheveleinNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ken Peeters Frederik Van Leemputte Baptiste Fischer Beatriz M. Bonini Hector Quezada Maksym Tsytlonok Dorien Haesen Ward Vanthienen Nuno Bernardes Carmen Bravo Gonzalez-Blas Veerle Janssens Peter Tompa Wim Versées Johan M. Thevelein Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
description	Yeast and cancer cells both favor sugar fermentation in aerobic conditions. Here the authors describe a conserved mechanism from yeast to mammals where the glycolysis intermediate fructose-1,6-bisphosphate binds Cdc25/Sos1 and couples increased glycolytic flux to increased Ras proto-oncoprotein activity.
format	article
author	Ken Peeters Frederik Van Leemputte Baptiste Fischer Beatriz M. Bonini Hector Quezada Maksym Tsytlonok Dorien Haesen Ward Vanthienen Nuno Bernardes Carmen Bravo Gonzalez-Blas Veerle Janssens Peter Tompa Wim Versées Johan M. Thevelein
author_facet	Ken Peeters Frederik Van Leemputte Baptiste Fischer Beatriz M. Bonini Hector Quezada Maksym Tsytlonok Dorien Haesen Ward Vanthienen Nuno Bernardes Carmen Bravo Gonzalez-Blas Veerle Janssens Peter Tompa Wim Versées Johan M. Thevelein
author_sort	Ken Peeters
title	Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
title_short	Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
title_full	Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
title_fullStr	Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
title_full_unstemmed	Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras
title_sort	fructose-1,6-bisphosphate couples glycolytic flux to activation of ras
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/d62a394b1ae143ca9a071cacf8de2008
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Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras

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