ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells

One type of RNA editing involves ADAR-mediated conversion of adenosine to inosine. Here the authors show that ADAR1 nuclear isoform p110 regulates R loop formation and genome stability at telomeres in cancer cells.

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Autores principales:	Yusuke Shiromoto, Masayuki Sakurai, Moeko Minakuchi, Kentaro Ariyoshi, Kazuko Nishikura
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/d62b10b4d1d74942aebc54b86dd22af0
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spelling	oai:doaj.org-article:d62b10b4d1d74942aebc54b86dd22af02021-12-02T15:52:28ZADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells10.1038/s41467-021-21921-x2041-1723https://doaj.org/article/d62b10b4d1d74942aebc54b86dd22af02021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21921-xhttps://doaj.org/toc/2041-1723One type of RNA editing involves ADAR-mediated conversion of adenosine to inosine. Here the authors show that ADAR1 nuclear isoform p110 regulates R loop formation and genome stability at telomeres in cancer cells.Yusuke ShiromotoMasayuki SakuraiMoeko MinakuchiKentaro AriyoshiKazuko NishikuraNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yusuke Shiromoto Masayuki Sakurai Moeko Minakuchi Kentaro Ariyoshi Kazuko Nishikura ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
description	One type of RNA editing involves ADAR-mediated conversion of adenosine to inosine. Here the authors show that ADAR1 nuclear isoform p110 regulates R loop formation and genome stability at telomeres in cancer cells.
format	article
author	Yusuke Shiromoto Masayuki Sakurai Moeko Minakuchi Kentaro Ariyoshi Kazuko Nishikura
author_facet	Yusuke Shiromoto Masayuki Sakurai Moeko Minakuchi Kentaro Ariyoshi Kazuko Nishikura
author_sort	Yusuke Shiromoto
title	ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
title_short	ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
title_full	ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
title_fullStr	ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
title_full_unstemmed	ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
title_sort	adar1 rna editing enzyme regulates r-loop formation and genome stability at telomeres in cancer cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/d62b10b4d1d74942aebc54b86dd22af0
work_keys_str_mv	AT yusukeshiromoto adar1rnaeditingenzymeregulatesrloopformationandgenomestabilityattelomeresincancercells AT masayukisakurai adar1rnaeditingenzymeregulatesrloopformationandgenomestabilityattelomeresincancercells AT moekominakuchi adar1rnaeditingenzymeregulatesrloopformationandgenomestabilityattelomeresincancercells AT kentaroariyoshi adar1rnaeditingenzymeregulatesrloopformationandgenomestabilityattelomeresincancercells AT kazukonishikura adar1rnaeditingenzymeregulatesrloopformationandgenomestabilityattelomeresincancercells
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ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells

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