NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies

NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies

Onion bulbs are a hallmark of demyelinating peripheral neuropathies. Here the authors identify Neuregulin-1 type I expression in Schwann cells as an essential mechanism involved in the formation of these characteristic structures.

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Autores principales: Robert Fledrich, Dagmar Akkermann, Vlad Schütza, Tamer A. Abdelaal, Doris Hermes, Erik Schäffner, M. Clara Soto-Bernardini, Tilmann Götze, Axel Klink, Kathrin Kusch, Martin Krueger, Theresa Kungl, Clara Frydrychowicz, Wiebke Möbius, Wolfgang Brück, Wolf C. Mueller, Ingo Bechmann, Michael W. Sereda, Markus H. Schwab, Klaus-Armin Nave, Ruth M. Stassart
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Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/d62e39531a3348db81bc0e371f8388cc
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spelling oai:doaj.org-article:d62e39531a3348db81bc0e371f8388cc2021-12-02T17:02:10ZNRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies10.1038/s41467-019-09385-62041-1723https://doaj.org/article/d62e39531a3348db81bc0e371f8388cc2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09385-6https://doaj.org/toc/2041-1723Onion bulbs are a hallmark of demyelinating peripheral neuropathies. Here the authors identify Neuregulin-1 type I expression in Schwann cells as an essential mechanism involved in the formation of these characteristic structures.Robert FledrichDagmar AkkermannVlad SchützaTamer A. AbdelaalDoris HermesErik SchäffnerM. Clara Soto-BernardiniTilmann GötzeAxel KlinkKathrin KuschMartin KruegerTheresa KunglClara FrydrychowiczWiebke MöbiusWolfgang BrückWolf C. MuellerIngo BechmannMichael W. SeredaMarkus H. SchwabKlaus-Armin NaveRuth M. StassartNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Robert Fledrich
Dagmar Akkermann
Vlad Schütza
Tamer A. Abdelaal
Doris Hermes
Erik Schäffner
M. Clara Soto-Bernardini
Tilmann Götze
Axel Klink
Kathrin Kusch
Martin Krueger
Theresa Kungl
Clara Frydrychowicz
Wiebke Möbius
Wolfgang Brück
Wolf C. Mueller
Ingo Bechmann
Michael W. Sereda
Markus H. Schwab
Klaus-Armin Nave
Ruth M. Stassart
NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
description Onion bulbs are a hallmark of demyelinating peripheral neuropathies. Here the authors identify Neuregulin-1 type I expression in Schwann cells as an essential mechanism involved in the formation of these characteristic structures.
format article
author Robert Fledrich
Dagmar Akkermann
Vlad Schütza
Tamer A. Abdelaal
Doris Hermes
Erik Schäffner
M. Clara Soto-Bernardini
Tilmann Götze
Axel Klink
Kathrin Kusch
Martin Krueger
Theresa Kungl
Clara Frydrychowicz
Wiebke Möbius
Wolfgang Brück
Wolf C. Mueller
Ingo Bechmann
Michael W. Sereda
Markus H. Schwab
Klaus-Armin Nave
Ruth M. Stassart
author_facet Robert Fledrich
Dagmar Akkermann
Vlad Schütza
Tamer A. Abdelaal
Doris Hermes
Erik Schäffner
M. Clara Soto-Bernardini
Tilmann Götze
Axel Klink
Kathrin Kusch
Martin Krueger
Theresa Kungl
Clara Frydrychowicz
Wiebke Möbius
Wolfgang Brück
Wolf C. Mueller
Ingo Bechmann
Michael W. Sereda
Markus H. Schwab
Klaus-Armin Nave
Ruth M. Stassart
author_sort Robert Fledrich
title NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
title_short NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
title_full NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
title_fullStr NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
title_full_unstemmed NRG1 type I dependent autoparacrine stimulation of Schwann cells in onion bulbs of peripheral neuropathies
title_sort nrg1 type i dependent autoparacrine stimulation of schwann cells in onion bulbs of peripheral neuropathies
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/d62e39531a3348db81bc0e371f8388cc
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